CAS No.5162-03-8,(2-Chlorophenyl)phenyl-methanone Suppliers

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Basic Information

Molecular Structure:
CAS No.:	5162-03-8
Name:	(2-Chlorophenyl)phenyl-methanone
Article Data:	115

Formula:	C₁₃H₉ClO
Molecular Weight:	216.667
Synonyms:	Benzophenone,2-chloro- (6CI,7CI,8CI);(2-Chlorophenyl)(phenyl)methanone;2-Benzoylphenylchloride;Methanone,(2-chlorophenyl)phenyl-;2-Chlorophenyl phenyl ketone;NSC 62529;o-Chlorobenzophenone;
EINECS:	225-936-9
Density:	1.207 g/cm³
Melting Point:	44-47 °C(lit.)
Boiling Point:	330.6 °C at 760 mmHg
Flash Point:	175.2 °C
Solubility:	Insoluble AUTOIGNITION
Appearance:	white to yellow crystalline powder
Hazard Symbols:	Xn, Xi
Risk Codes:	36/37/38-20/21/22
Safety:	37/39-26-24/25-36
Transport Information:	25kgs
PSA:	17.07000
LogP:	3.57100

Synthetic route

: 609-65-4
o-chlorobenzoyl chloride

: 71-43-2
benzene

: 5162-03-8
(2-chlorophenyl)(phenyl)methanone

Conditions

Conditions	Yield
With aluminium trichloride for 19.5h; Heating;	100%
Friedel-Crafts reaction;	90%
iron(III) chloride at 109℃; for 0.458333h; Product distribution / selectivity; Irradiation;	83%

: 71225-69-9
(2-chlorophenyl)phenylmethanone oxime

: 5162-03-8
(2-chlorophenyl)(phenyl)methanone

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 20℃; for 0.0166667h; neat (no solvent);	98%
With periodic acid at 20℃; for 0.3h;	86%

: 98-88-4
benzoyl chloride

: 108-90-7
chlorobenzene

: 5162-03-8
(2-chlorophenyl)(phenyl)methanone

Conditions

Conditions	Yield
With C4F9SO3H at 130℃; for 0.333333h; Product distribution; var. of time, conc. of reagent;	96%
With aluminum (III) chloride for 6h; Friedel-Crafts Acylation; Reflux;

: 143-66-8
sodium tetraphenyl borate

: 609-65-4
o-chlorobenzoyl chloride

: 5162-03-8
(2-chlorophenyl)(phenyl)methanone

Conditions

Conditions	Yield
With potassium fluoride; bis-triphenylphosphine-palladium(II) chloride In acetone for 0.15h; microwave irradiation (525 W);	94%
With aluminum oxide; bis-triphenylphosphine-palladium(II) chloride; potassium fluoride In acetone for 0.0833333h; MW-irradiation;	90%
With silica-supported diphenylphosphine palladium(0) In tetrahydrofuran at 40℃; for 48h;	74%

: 6954-45-6, 16071-25-3, 16071-26-4, 134236-27-4
(2-chlorophenyl)(phenyl)methanol

: 5162-03-8
(2-chlorophenyl)(phenyl)methanone

Conditions

Conditions	Yield
With cobalt(III) acetate; sodium bromide In acetic acid at 60℃; for 1h;	93%
With peracetic acid; 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy In acetonitrile at 20℃; for 9h;	93%
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione at 80℃; for 0.5h; Reagent/catalyst;	92%

: 29921-41-3
(o-benzyl)chlorobenzene

: 5162-03-8
(2-chlorophenyl)(phenyl)methanone

Conditions

Conditions	Yield
With pyridine; tert.-butylhydroperoxide; iodine In water at 80℃; chemoselective reaction;	93%
With N-Bromosuccinimide; water In chloroform for 3h; Reflux;	92%
With lithium perchlorate In water; acetonitrile at 20℃; for 5h; Electrolysis;	67%

: 3900-89-8
2-Chlorobenzeneboronic acid

: 98-88-4
benzoyl chloride

: 5162-03-8
(2-chlorophenyl)(phenyl)methanone

Conditions

Conditions	Yield
With 2C60H80NaO12(2+)*Cl6Pd2(2-); potassium carbonate; triphenylphosphine In toluene at 70℃; for 12h; Suzuki Coupling;	93%
With [Pd(η(5)-C5H5)Fe(η(5)-C5H3-C(CH3)=N-C6H4-4-CH3)Cl(P(C6H5)3)]; potassium carbonate In toluene at 60℃; for 12h; Inert atmosphere;	90%

: 24892-81-7
1-(o-chlorophenyl)-1-phenylethylene

: 5162-03-8
(2-chlorophenyl)(phenyl)methanone

Conditions

Conditions	Yield
With oxygen at 110℃; for 8h; Schlenk technique; Green chemistry;	91%
With oxygen at 110℃; for 8h; Sealed tube;	90.9%
With cerium(III) chloride; 1,1,1-trichloroethanol In acetonitrile at 25℃; for 40h; Irradiation;	78%

: 1657-52-9
(E)-2-chlorostilbene

: 5162-03-8
(2-chlorophenyl)(phenyl)methanone

Conditions

Conditions	Yield
With sodium periodate; tetraethylammonium iodide In water; acetonitrile at 105℃; for 12h; Sealed tube;	89%

: 591-50-4
iodobenzene

: 201230-82-2
carbon monoxide

: chlorophenyltriethoxysilane

: 5162-03-8
(2-chlorophenyl)(phenyl)methanone

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); cesium fluoride In 1-methyl-pyrrolidin-2-one at 80℃; under 760.051 Torr; for 6h; Hiyama Coupling;	88%

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Chemistry

Structure of 2-Chlorobenzophenone (CAS NO.5162-03-8):

IUPAC Name: (2-Chlorophenyl)-phenylmethanone
Molecular Formula: C₁₃H₉ClO
Molar mass: 216.663 g/mol
Density: 1.207 g/cm³
Flash Point: 175.2 °C
Index of Refraction: 1.594
Melting Point: 44-47 °C(lit.)
Boiling Point: 330.6 °C at 760 mmHg
Vapour Pressure: 0.000164 mmHg at 25 °C
XLogP3: 4
H-Bond Acceptor: 1
Rotatable Bond Count: 2
Exact Mass: 216.034193
MonoIsotopic Mass: 216.034193
Topological Polar Surface Area: 17.1
Heavy Atom Count: 15
Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=CC=CC=C2Cl
InChI: InChI=1S/C13H9ClO/c14-12-9-5-4-8-11(12)13(15)10-6-2-1-3-7-10/h1-9H
InChIKey: VMHYWKBKHMYRNF-UHFFFAOYSA-N
EINECS: 225-936-9
Product Categories: Aromatic Benzophenones & Derivatives (substituted); Functional Materials; Photopolymerization Initiators; C13 to C14; Carbonyl Compounds; Ketones

Uses

2-Chlorobenzophenone (CAS NO.5162-03-8) can be used as pharmaceutical intermediates.

Toxicity Data With Reference

mouse

oral

> 500mg/kg (500mg/kg)

BEHAVIORAL: MUSCLE WEAKNESS

National Technical Information Service. Vol. OTS0544006,

Safety Profile

Hazard Codes: Irritant Xi, Harmful Xn
Risk Statements: 36/37/38-20/21/22
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 37/39-26-24/25-36
S37/39:Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S24/25:Avoid contact with skin and eyes.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: PC4945633
Hazard Note: Irritant

Specification

2-Chlorobenzophenone (CAS NO.5162-03-8) is also named as (2-Chlorophenyl)phenylmethanone ; 2-Chlorobenyl phenyl ketone ; AI3-22112 ; NSC 62529 ; o-Chlorobenzophenone ; Benzophenone, 2-chloro- (6CI,7CI,8CI) ; Methanone, (2-chlorophenyl)phenyl- . 2-Chlorobenzophenone (CAS NO.5162-03-8) is white to yellow crystalline powder.