CAS No.51762-05-1,Cefroxadine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	51762-05-1
Name:	Cefroxadine
Article Data:	3

Formula:	C16H19 N3 O5 S
Molecular Weight:	365.41
Synonyms:	5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[(amino-1,4-cyclohexadien-1-ylacetyl)amino]-3-methoxy-8-oxo-, [6R-[6a,7b(R*)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2R)-amino-1,4-cyclohexadien-1-ylacetyl]amino]-3-methoxy-8-oxo-, (6R,7R)-(9CI); CGP 9000; Cefroxadine; Oraspor
EINECS:	257-391-8
Density:	1.5 g/cm³
Melting Point:	170° (dec)
Boiling Point:	719.3 °C at 760 mmHg
Flash Point:	388.8 °C
Safety:	Mildly toxic by ingestion and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of SO_x and NO_x.
PSA:	147.26000
LogP:	0.96170

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Chemistry

Chemistry informtion about Cefroxadin (CAS NO.51762-05-1) is:
IUPAC Name: (6r,7r)-7-[[(2r)-2-Amino-2-Cyclohexa-1,4-Dien-1-Ylacetyl]Amino]-3-Methoxy-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid ; (6S,7S)-7-[(2-amino-2-cyclohexa-2,5-dien-1-ylacetyl)amino]-3-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonyms: (6r-(6-Alpha,7-Beta(R*)))-Ien-1-Ylacetyl)Amino)-3-Methoxy-8-Oxo ; 7-(D-2-Amino-2-(1,4-Cyclohexadienyl)Acetamide)-3-Methoxy-3-Cephem-4-Carboxyl ; Antibioticcgp9000 ; Cefroxadin ; Cgp9000 ; Cxd ; Cefroxadine ; 5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid, 7-[(Amino-1,4-Cyclohexadien-1-Ylacetyl)Amino]-3-Methoxy-8-Oxo-, [6r-[6α,7β(R*)]]-
MF: C₁₆H₁₉N₃O₅S
MW: 365.4
EINECS: 257-391-8
Density: 1.5 g/cm³
Flash Point: 388.8 °C
Boiling Point: 719.3 °C at 760 mmHg
Vapour Pressure: 1.23E-22 mmHg at 25°C
Enthalpy of Vaporization: 114.44 kJ/mol
Following is the molecular structure of Cefroxadin (CAS NO.51762-05-1) is:

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 1gm/kg (1000mg/kg)		Drugs in Japan Vol. -, Pg. 689, 1995.
mouse	LD50	intraperitoneal	7090mg/kg (7090mg/kg)		Journal of Antibiotics. Vol. 29, Pg. 653, 1976.
mouse	LD50	oral	> 13500mg/kg (13500mg/kg)	behavioral: somnolence (general depressed activity) gastrointestinal: "hypermotility, diarrhea"	Chemotherapy Vol. 28(Suppl,
mouse	LD50	subcutaneous	13500mg/kg (13500mg/kg)	behavioral: somnolence (general depressed activity) gastrointestinal: "hypermotility, diarrhea"	Chemotherapy Vol. 28(Suppl,
rabbit	LD50	intraperitoneal	> 4gm/kg (4000mg/kg)	kidney, ureter, and bladder: structural or functional changes in ureter kidney, ureter, and bladder: other changes	Chemotherapy Vol. 28(Suppl,
rabbit	LD50	oral	10gm/kg (10000mg/kg)		Drugs in Japan Vol. 6, Pg. APP-11, 1982.
rat	LD50	intraperitoneal	6gm/kg (6000mg/kg)	behavioral: ataxia gastrointestinal: "hypermotility, diarrhea" skin and appendages (skin): hair: other	Chemotherapy Vol. 28(Suppl,
rat	LD50	oral	> 22500mg/kg (22500mg/kg)	behavioral: altered sleep time (including change in righting reflex) behavioral: somnolence (general depressed activity) gastrointestinal: "hypermotility, diarrhea"	Chemotherapy Vol. 28(Suppl,
rat	LD50	subcutaneous	> 15gm/kg (15000mg/kg)	sense organs and special senses: mydriasis (pupillary dilation): eye behavioral: altered sleep time (including change in righting reflex) skin and appendages (skin): hair: other	Chemotherapy Vol. 28(Suppl,

Safety Profile

Mildly toxic by ingestion and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of SO_x and NO_x.