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| CAS No.: | 52-26-6 |
|---|---|
| Name: | MORPHINIUM CHLORIDE |
| Article Data: | 1 |
| Molecular Structure: | |
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| Formula: | C17H19 N O3 . Cl H |
| Molecular Weight: | 321.804 |
| Synonyms: | Morphinan-3,6-diol,7,8-didehydro-4,5-epoxy-17-methyl- (5a,6a)-, hydrochloride (9CI); Morphinan-3,6a-diol, 7,8-didehydro-4,5a-epoxy-17-methyl-, hydrochloride (8CI); (-)-Morphinehydrochloride; Ampek; Epimore; Morphine chlorhydrate; Morphine hydrochloride;Morphine monohydrochloride; Opso; Pacif; Pacif capsules; Theba-Intran;Thebametten |
| Density: | g/cm3 |
| Melting Point: | about 200° (dec) |
| Boiling Point: | 476.2°Cat760mmHg |
| Flash Point: | 241.8°C |
| Hazard Symbols: | F,T |
| Risk Codes: | 11-23/24/25-39/23/24/25 |
| Safety: | Poison by ingestion, intraperitoneal, intravenous, parenteral, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Abuse leads to habituation or addiction. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also (−)-MORPHINE. |
| PSA: | 188.84000 |
| LogP: | 2.70000 |
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Chemistry
Chemistry informtion about Morphinium Chloride (52-26-6) is:
Synonyms: 6-Alpha-Diol,7,8-Didehydro-4,5-Alpha-Epoxy-17-Methyl-Morphinan-Hydrochlo;Ampek ; Morphinan-3,6-Diol,7,8-Didehydro-4,5-Epoxy-17-Methyl-,Hydrochloride,(5-Alpha ; Morphinechlorhydrate ; Morphinechloride ; Theba-Intran;Morphin-Hcl ; Morphinium Chloride
MF: C17H20ClNO3
MW: 321.8
EINECS: 200-136-2
Flash Point: 241.8 °C
Boiling Point: 476.2 °C at 760 mmHg
Vapour Pressure: 7.06E-10 mmHg at 25°C
Enthalpy of Vaporization: 77.95 kJ/mol
Storage temp.: −20°C
Following is the molecular structure of Morphinium Chloride (52-26-6) is:
Uses
Morphinium Chloride (52-26-6) can be used as an analgesic to relieve and as an antitussive for severe cough.
Toxicity Data With Reference
| 1. | orl-rat LD50:335 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 115 (1958),213. | ||
| 2. | scu-rat LD50:480 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 115 (1958),213. | ||
| 3. | ivn-rat LD50:265 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 115 (1958),213. | ||
| 4. | orl-mus LD50:745 mg/kg | JJPAAZ Japanese Journal of Pharmacology. 18 (1968),406. | ||
| 5. | ipr-mus LD50:148 mg/kg | BJPCBM British Journal of Pharmacology. 73 (1981),887. | ||
| 6. | scu-mus LD50:354 mg/kg | KSRNAM Kiso to Rinsho. Clinical Report. 5 (1971),1787. | ||
| 7. | ivn-mus LD50:180 mg/kg | ATSUDG Archives of Toxicology, Supplement. 7 (1984),90. | ||
| 8. | par-mus LD50:440 mg/kg | WKMRAH Wakayama Medical Report. 24 (4)(1983),65. | ||
| 9. | ivn-dog LD50:175 mg/kg | CPBTAL Chemical and Pharmaceutical Bulletin. 7 (1959),372. |
Consensus Reports
EPA Genetic Toxicology Program.
Safety Profile
Poison by ingestion, intraperitoneal, intravenous, parenteral, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Abuse leads to habituation or addiction. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also (−)-MORPHINE.
Hazard Codes:
F: Flammable
T: Toxic
Risk Statements:
R11: Highly flammable.
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R39/23/24/25: Danger of very serious irreversible effects and toxic by inhalation, in contact with skin and if swallowed.
Safety Statements:
S7: Keep container tightly closed.
S16: Keep away from sources of ignition.
S24: Avoid contact with skin.
S33: Take precautionary measures against static discharges.
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 1230 3/PG 2
WGK Germany: 1