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| CAS No.: | 52-88-0 |
|---|---|
| Name: | ATROPINE METHYL NITRATE |
| Molecular Structure: | |
|
|
|
| Formula: | C18H26NO3•NO3 |
| Molecular Weight: | 366.414 |
| Synonyms: | atropinemethonitrate;Atropinemethonitrate;ATROPINEMETHYLNITRATE;Methylatropinenitrate; |
| Density: | g/cm3 |
| Melting Point: | 163°C |
| Boiling Point: | °Cat760mmHg |
| Flash Point: | °C |
| Hazard Symbols: | Xn,T+ |
| Risk Codes: | 22-26/28 |
| Safety: | Poison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects: mydriasis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also ATROPINE and NITRATES. |
| PSA: | 115.41000 |
| LogP: | 2.31840 |
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| Conditions | Yield |
|---|---|
| With ethanol Bromid; |
| Conditions | Yield |
|---|---|
| With methanol at 110℃; |
- 52-88-0
atropine methyl nitrate
| Conditions | Yield |
|---|---|
| With silver sulfate und behandelt das entstandene Sulfat mit Bariumnitrat oder Bleinitrat; |
- 52-88-0
atropine methyl nitrate
| Conditions | Yield |
|---|---|
| With water; silver(l) oxide und neutralisiert mit Salpetersaeure; | |
| With silver sulfate und behandelt das entstandene Sulfat mit Bariumnitrat oder Bleinitrat; |
- 52-88-0
atropine methyl nitrate
| Conditions | Yield |
|---|---|
| With water |
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Chemistry
Molecular Structure of Methylatropine nitrate (CAS NO.52-88-0): .png)
Molecular Formula: C18H26N2O6
Molecular Weight: 366.40884 g/mol
Classification Code: Anticholinergic ; Drug / Therapeutic Agent ; Human Data ; Reproductive Effect
IUPAC: (8,8-Dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate nitrate
Synonyms: 1-alpha-H,5-alpha-H-Tropanium, 3-alpha-hydroxy-8-methyl-, nitrate, (+-)-tropate (ester) ; 3-alpha-Hydroxy-8-methyl-1-alpha-H,5-alpha-H-tropanium bromide (+,-)-tropate ; 3alpha-Hydroxy-8-methyl-1alphaH,5alphaH-tropanium bromide (+-)-tropate ; 8-Azoniabicyclo(3.2.1)octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8,8-dimethyl-, endo-(+-)-, nitrate (salt) ;
8-Methylatropinium nitrate ; Atropina metonitrato ; Atropina metonitrato [DCIT] ; Atropine methyl nitrate ; Atropine methylnitrate ; Atropini methonitras ; Atropini methonitras [INN-Latin]
CAS: 52-88-0
EINECS: 200-156-1
Melting point: 163°C
Solubility H2O: 50 mg/mL
Form: powder
Color: white
Merck: 875
Toxicity Data With Reference
Toxicity of Methylatropine nitrate (CAS NO.52-88-0):
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| frog | LDLo | subcutaneous | 50mg/kg (50mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1312, 1935. | |
| guinea pig | LD50 | subcutaneous | 95mg/kg (95mg/kg) | AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 375, 1962 |
| human | TDLo | intramuscular | 2ug/kg (0.002mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | "Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents," National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85Vol. 1, Pg. L1, 1982. |
| mouse | LD50 | intraperitoneal | 9mg/kg (9mg/kg) | Archiv fuer Toxikologie. Vol. 29, Pg. 39, 1972. | |
| mouse | LD50 | intravenous | 9300ug/kg (9.3mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 110, Pg. 282, 1954. | |
| mouse | LD50 | oral | 1320mg/kg (1320mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 120, Pg. 511, 1965. | |
| pigeon | LDLo | subcutaneous | 40mg/kg (40mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1312, 1935. | |
| rat | LD50 | oral | 1902mg/kg (1902mg/kg) | Toxicology and Applied Pharmacology. Vol. 1, Pg. 42, 1959. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Hazard Codes of Methylatropine nitrate (CAS NO.52-88-0): 
Xn
Risk Statements : 22
Safety Statements : S22:Do not breathe dust. S36:Wear suitable protective clothing.
RIDADR : 1544
WGK Germany : 3
RTECS :CK2800000
Poison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects: mydriasis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also ATROPINE and NITRATES.