CAS No.52-88-0,ATROPINE METHYL NITRATE Suppliers

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Basic Information

Molecular Structure:
CAS No.:	52-88-0
Name:	ATROPINE METHYL NITRATE

Formula:	C₁₈H₂₆NO₃•NO₃
Molecular Weight:	366.414
Synonyms:	atropinemethonitrate;Atropinemethonitrate;ATROPINEMETHYLNITRATE;Methylatropinenitrate;
Density:	g/cm³
Melting Point:	163°C
Boiling Point:	°Cat760mmHg
Flash Point:	°C
Hazard Symbols:	Xn,T+
Risk Codes:	22-26/28
Safety:	Poison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects: mydriasis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x. See also ATROPINE and NITRATES.
PSA:	115.41000
LogP:	2.31840

Synthetic route

: 74-83-9
methyl bromide

: 51-55-8
atropine

: 52-88-0
atropine methyl nitrate

Conditions

Conditions	Yield
With ethanol Bromid;

: 598-58-3
methyl nitrate

: 51-55-8
atropine

: 52-88-0
atropine methyl nitrate

Conditions

Conditions	Yield
With methanol at 110℃;

atropine chloromethylate: atropine chloromethylate

: 52-88-0
atropine methyl nitrate

Conditions

Conditions	Yield
With silver sulfate und behandelt das entstandene Sulfat mit Bariumnitrat oder Bleinitrat;

atropine iodomethylate: atropine iodomethylate

: 52-88-0
atropine methyl nitrate

Conditions

Conditions	Yield
With water; silver(l) oxide und neutralisiert mit Salpetersaeure;
With silver sulfate und behandelt das entstandene Sulfat mit Bariumnitrat oder Bleinitrat;

atropine iodomethylate: atropine iodomethylate

silver nitrate: silver nitrate

: 52-88-0
atropine methyl nitrate

Conditions

Conditions	Yield
With water

Raw Materials

51-55-8

598-58-3

74-83-9

Total:62 Page 1 of 2 1 2 Next>>

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Chemistry

Molecular Structure of Methylatropine nitrate (CAS NO.52-88-0):
Molecular Formula: C₁₈H₂₆N₂O₆
Molecular Weight: 366.40884 g/mol
Classification Code: Anticholinergic ; Drug / Therapeutic Agent ; Human Data ; Reproductive Effect
IUPAC: (8,8-Dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate nitrate
Synonyms: 1-alpha-H,5-alpha-H-Tropanium, 3-alpha-hydroxy-8-methyl-, nitrate, (+-)-tropate (ester) ; 3-alpha-Hydroxy-8-methyl-1-alpha-H,5-alpha-H-tropanium bromide (+,-)-tropate ; 3alpha-Hydroxy-8-methyl-1alphaH,5alphaH-tropanium bromide (+-)-tropate ; 8-Azoniabicyclo(3.2.1)octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8,8-dimethyl-, endo-(+-)-, nitrate (salt) ;
8-Methylatropinium nitrate ; Atropina metonitrato ; Atropina metonitrato [DCIT] ; Atropine methyl nitrate ; Atropine methylnitrate ; Atropini methonitras ; Atropini methonitras [INN-Latin]
CAS: 52-88-0
EINECS: 200-156-1
Melting point: 163°C
Solubility H₂O: 50 mg/mL
Form: powder
Color: white
Merck: 875

Toxicity Data With Reference

Toxicity of Methylatropine nitrate (CAS NO.52-88-0):

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
frog	LDLo	subcutaneous	50mg/kg (50mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1312, 1935.
guinea pig	LD₅₀	subcutaneous	95mg/kg (95mg/kg)	AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 375, 1962
human	TDLo	intramuscular	2ug/kg (0.002mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE	"Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents," National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85Vol. 1, Pg. L1, 1982.
mouse	LD₅₀	intraperitoneal	9mg/kg (9mg/kg)		Archiv fuer Toxikologie. Vol. 29, Pg. 39, 1972.
mouse	LD₅₀	intravenous	9300ug/kg (9.3mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 110, Pg. 282, 1954.
mouse	LD₅₀	oral	1320mg/kg (1320mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 120, Pg. 511, 1965.
pigeon	LDLo	subcutaneous	40mg/kg (40mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1312, 1935.
rat	LD₅₀	oral	1902mg/kg (1902mg/kg)		Toxicology and Applied Pharmacology. Vol. 1, Pg. 42, 1959.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Hazard Codes of Methylatropine nitrate (CAS NO.52-88-0): Harmful Xn
Risk Statements : 22
Safety Statements : S22:Do not breathe dust. S36:Wear suitable protective clothing.
RIDADR : 1544
WGK Germany : 3
RTECS :CK2800000
Poison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects: mydriasis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x. See also ATROPINE and NITRATES.