CAS No.520-33-2,Hesperetin Suppliers

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Basic Information

Molecular Structure:
CAS No.:	520-33-2
Name:	Hesperetin
Article Data:	54

Formula:	C₁₆H₁₄O₆
Molecular Weight:	302.284
Synonyms:	(2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)chroman-4-one;(S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone;Flavanone, 3,5, 7-trihydroxy-4-methoxy-;5,7-dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)chroman-4-one;Flavanone, 3,5,7-trihydroxy-4-methoxy- (VAN) (8CI);4H-1-Benzopyran-4-one,2,3-dihydro-5,7- dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-,(2S)-;5,7,3-Trihydroxy-4-methoxyflavanone;Prestwick_908;3,5,7-Trihydroxy-4-methoxyflavanone;4H-1-Benzopyran-4-one, 2,3-dihydro-5, 7-dihydroxy-2- (3-hydroxy-4-methoxyphenyl)-, (S)-;5,7, 3-Trihydroxy-4-methoxyflavanone;Cyanidanon 4-methyl ether 1626;
EINECS:	208-290-2
Density:	1.458 g/cm³
Melting Point:	230-232 °C
Boiling Point:	586.2 °C at 760 mmHg
Flash Point:	223 °C
Solubility:	water-soluble
Appearance:	Beige to Light Brown Crystalline Solid
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36/37/39-27
PSA:	96.22000
LogP:	2.51850

Synthetic route

: 520-26-3
hesperidin

: 520-33-2
hesperetin

Conditions

Conditions	Yield
With sulfuric acid; acetic acid In water for 12h; Reflux;	98%
With sulfuric acid In water at 121℃; for 4h; High pressure;	87%
With sulfuric acid In ethanol for 8h; Reflux;	87%

: 90-33-5, 79566-13-5
7-hydroxy-4-methyl-chromen-2-one

: 520-26-3
hesperidin

A: 1356391-89-3
4-methylumbelliferyl-rutinoside

B: 520-33-2
hesperetin

Conditions

Conditions	Yield
With water In dimethyl sulfoxide at 30℃; for 1h; pH=5; aq. buffer; Enzymatic reaction;	A 28% B n/a

...Expand

: 520-26-3
hesperidin

A: 520-33-2
hesperetin

B: 3′,5,7,8-tetrahydroxy-4′-methoxyflavanone

Conditions

Conditions	Yield
With Aspergillus saitoi In water; dimethyl sulfoxide at 30℃; pH=5.0;	A n/a B 3.5%

: 520-26-3
hesperidin

A: 520-33-2
(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone

B: 520-33-2
hesperetin

Conditions

Conditions	Yield
With sulfuric acid; ethylene glycol
With sulfuric acid
With methanol; sulfuric acid

: 520-26-3
hesperidin

A: 2280-44-6
D-Glucose

B: 73-34-7
L-rhamnose

C: hesperetin 7‐O‐β‐D‐glucopyranoside

D: 520-33-2
hesperetin

Conditions

Conditions	Yield
With sulfuric acid In water at 140℃; for 1h; Kinetics; Product distribution; Further Variations:; pH-values; Reagents; Temperatures; Hydrolysis;

...Expand

: 520-26-3
hesperidin

A: hesperetin-7-glucoside

B: 520-33-2
hesperetin

Conditions

Conditions	Yield
L. acidophilus NCC 3010 crude extract for 4 - 8h; pH=4 - 6; Product distribution / selectivity; Enzymatic reaction;
L. plantarum NCC 1313 crude extract for 4 - 8h; pH=4 - 6; Product distribution / selectivity; Enzymatic reaction;

: 161713-86-6
4G-α-D-glucopyranosyl hesperidin

A: 520-26-3
hesperidin

B: 520-33-2
hesperetin

Conditions

Conditions	Yield
With small intestine homogenate of rat at 37℃; for 4h; Title compound not separated from byproducts.;

concentrated H2 SO4: concentrated H2 SO4

: 520-26-3
hesperidin

: 520-33-2
hesperetin

Conditions

Conditions	Yield
In methanol; water

: 520-33-2
(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone

A: 24604-97-5
(R)-4'-methoxy-3',5,7-trihydroxyflavanone

B: 520-33-2
hesperetin

Conditions

Conditions	Yield
With ammonium acetate In water; isopropyl alcohol pH=5; Resolution of racemate;
With per(4-chloro-3-methyl)phenylcarbamate β-cyclodextrin clicked onto an alkynyl surface modified silica support In ethanol; hexane at 25℃; Resolution of racemate;

: 67-56-1
methanol

: 520-26-3
hesperidin

A: 184239-14-3
C13H24O10

B: 520-33-2
hesperetin

Conditions

Conditions	Yield
With water at 30℃; for 1h; pH=5; aq. buffer; Enzymatic reaction;

...Expand

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Chemistry

IUPAC Name: 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one
Synonyms of Hesperetin (CAS NO.520-33-2): 3',5,7-Trihydroxy-4'-methoxyflavanone ; 5,7,3'-Trihydroxy-4'-methoxyflavanone ; Hesperitin ; (S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone ; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)- (9CI) ; Flavanone, 3',5,7-trihydroxy-4'-methoxy- (VAN) (8CI)
CAS NO:520-33-2
Molecular Formula:C₁₆H₁₄O₆
Molecular Weight :302.2788
Molecular Structure :
EINECS: 208-290-2
H bond acceptors: 6
H bond donors: 3
Freely Rotating Bonds: 5
Polar Surface Area: 63.22 Å²
Index of Refraction: 1.664
Molar Refractivity: 76.93 cm³
Molar Volume: 207.2 cm³
Surface Tension: 67.4 dyne/cm
Density: 1.458 g/cm³
Flash Point: 223 °C
Enthalpy of Vaporization: 90.79 kJ/mol
Boiling Point: 586.2 °C at 760 mmHg
Vapour Pressure: 2.45E-14 mmHg at 25°C
Melting Point: 230-232°C
Appearance: Beige to Light Brown Crystalline Solid
Storage temp: 2-8°C .
Product Categories of Hesperetin (CAS NO.520-33-2): Flavanones;Biochemistry;Flavonoids;Natural Plant Extract;Inhibitors
SMILES: O=C2c3c(OC(c1ccc(OC)c(O)c1)C2)cc(O)cc3O
InChI: InChI=1/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3
InChIKey: AIONOLUJZLIMTK-UHFFFAOYAH
Std. InChI: InChI=1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3
Std. InChIKey: AIONOLUJZLIMTK-UHFFFAOYSA-N

Uses

Hesperetin (CAS NO.520-33-2) is used as the aglucon of hesperidin.

Production

Hesperidin is found in Citrus fruits.

Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39-27
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27: Take off immediately all contaminated clothing.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany: 3

Specification

Hesperetin (CAS NO.520-33-2) is a bioflavonoid and specificly it is a flavanone. Hesperidin is water-soluble due to the presence of the sugar part in its structure, so on ingestion it releases its aglycone, i.e, hesperetin.