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53-41-8

Basic Information
CAS No.: 53-41-8
Name: Androsterone
Article Data: 109
Molecular Structure:
Molecular Structure of 53-41-8 (Androsterone)
Formula: C19H30O2
Molecular Weight: 290.446
Synonyms: 3-Epihydroxyetioallocholan-17-one;3a-Hydroxy-17-androstanone;3a-Hydroxy-5a-androstan-17-one;3a-Hydroxy-5a-androstane-17-one;5a-Androstan-17-one-3a-ol;5a-Androstane-3a-ol-17-one;5a-Androsterone;Androkinin;Androtin;Atromide ICI;NSC9898;U 60366;
EINECS: 200-173-4
Density: 1.085 g/cm3
Melting Point: 181-184 °C(lit.)
Boiling Point: 413.139 °C at 760 mmHg
Flash Point: 176.377 °C
Solubility: 11.5mg/L(23.5 oC)
Appearance: white to light beige crystalline powder
Hazard Symbols: Xi
Risk Codes: 36/37/38-43
Safety: 22-24/25
PSA: 37.30000
LogP: 3.95910
Synthetic route
111222-34-5

(3R,5S,8R,9S,10S,13S,14S)-10,13-Dimethyl-3-(tetrahydro-furan-2-yloxy)-hexadecahydro-cyclopenta[a]phenanthren-17-one

53-41-8

cis-androsterone

Conditions
ConditionsYield
With toluene-4-sulfonic acid In ethanol for 1h; Ambient temperature;100%
1164-95-0

androsterone acetate

53-41-8

cis-androsterone

Conditions
ConditionsYield
With methanol; sodium hydroxide at 40℃; for 4h; Inert atmosphere;94.6%
With potassium carbonate

2-Oxo-propionic acid (3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

A

53-41-8

cis-androsterone

B

846-46-8

androstanedione

Conditions
ConditionsYield
With Oxone; edetate disodium; sodium hydrogencarbonate In water; acetonitrile at 20℃; for 120h;A 20%
B 78%
5953-69-5

3α-hydroxy-5α-androstan-17-one 3-benzoate

53-41-8

cis-androsterone

Conditions
ConditionsYield
With sodium methylate In methanol; dichloromethane at 20℃;75%
846-46-8

androstanedione

A

481-29-8

Epiandrosterone

B

53-41-8

cis-androsterone

Conditions
ConditionsYield
With trimethylamine-borane; silica gel; iron(III) chloride In benzene for 2h; Ambient temperature;A 60.2%
B 20.9%
With trimethylamine-borane; silica gel; iron(III) chloride In benzene for 2h; Product distribution; Ambient temperature; various catalysts and times;A 60.2%
B 20.9%
With hydrogen; Nic In tetrahydrofuran; ethanol at 25℃; under 760 Torr; for 1.16667h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
5717-77-1, 15807-49-5, 35420-27-0, 57194-49-7

(3α,5α)-3-hydroxyandrostan-17-one 1,2-ethanediyl acetal

53-41-8

cis-androsterone

Conditions
ConditionsYield
With methanesulfonic acid In methanol; water for 0.25h;57%
With acetic acid
592509-66-5

2-Oxo-heptanoic acid (3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

A

53-41-8

cis-androsterone

B

(2R,6R)-2-Hydroxy-6-methyl-tetrahydro-pyran-2-carboxylic acid (3R,5R,8R,9S,10S,13S,14S)-10,13-dimethyl-17-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Conditions
ConditionsYield
With Oxone; edetate disodium; sodium hydrogencarbonate In water; acetonitrile at 20℃; for 72h;A 45%
B 55%
1852-53-5

androstanediol

53-41-8

cis-androsterone

Conditions
ConditionsYield
With HEK-293 cells expressing Haliotis diversicolor supertexta 17β-hydroxysteroid dehydrogenase 11; fetal bovine serum In dimethyl sulfoxide for 23h; aq. buffer; Enzymatic reaction;53.4%
With rabbit 3-hydroxyhexobarbital dehydrogenase (AKR1C29); NADP In aq. phosphate buffer; ethyl acetate at 37℃; for 0.5h; pH=7.4; Catalytic behavior; Kinetics; Enzymatic reaction;
With recombinant male golden hamster liver aldo-keto reductase AKR1C35; NAD In aq. phosphate buffer at 25℃; pH=7.4; Kinetics; Enzymatic reaction;
10429-07-9

3β-tosyloxy-5α-androstan-17-one

A

53-41-8

cis-androsterone

B

846-46-8

androstanedione

Conditions
ConditionsYield
With potassium nitrite In N,N-dimethyl-formamide at 80 - 85℃; for 18h;A 51.5%
B 0.03 g
C 0.01 g
846-46-8

androstanedione

A

481-29-8

Epiandrosterone

B

53-41-8

cis-androsterone

C

571-20-0

5-androgen-3,17-diol

Conditions
ConditionsYield
for 504h; Rhodotorula mucilaginosa;A 18%
B 35%
C 30%
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    Product name: Androsterone CAS No.:53-41-8 Molecule Formula:C19H30O2 Molecule Weight:290.44 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SPECIFI

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Chemistry

Chemical Formula: C19H30O2
Molecular Weight: 290.44
Synonyms: 3-hydroxy-,(3alpha,5alpha)-androstan-17-on ; 5alpha-Androstan-17-one, 3alpha-hydroxy- ; 3-alpha-hydroxy-17-androstanone ; 3-Epihydroxyetioallocholan-17-one ; 5alpha-Androstane-3alpha-ol-17-one
Melting Point: 181-184 °C(lit.)
Flash Point: 176.4 °
Boiling Point: 413.1 °C at 760 mmHg
Density of Androsterone (53-41-8) : 1.085 g/cm3 
Vapour Pressure: 1.5E-08 mmHg at 25°C
alpha of Androsterone (53-41-8) : 96°(c=1, C2H5OH)
storage temp.: -20°C
Index of Refraction: 1.536 
Chemical Properties: Androsterone (53-41-8) is a white to light beige crystalline powder

Safety Profile

An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Statements: 22: Do not breathe dust
24/25: Avoid contact with skin and eyes 
WGK Germany: 3
RTECS: BV8053000
F: 3: Hygroscopic
21: Sensitive to humidity
StorageKeep container tightly closed. Keep container in a cool, well-ventilated area.

Specification

Storage: Keep container in a cool, well-ventilated area. Keep container tightly closed.