CAS No.530-43-8,Chloramphenicol palmitate Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	530-43-8
Name:	Chloramphenicol palmitate
Article Data:	13

Formula:	C₂₇H₄₂Cl₂N₂O₆
Molecular Weight:	561.546
Synonyms:	Hexadecanoicacid, (2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl ester(9CI);Palmitic acid, ester with chloramphenicol (6CI);Chlorambon;Chloramphenicol monopalmitate;Chloramphenicol monopalmitate(ester);Chloramphenicol palmitate (ester);D-(-)-Chloramphenicolpalmitate;
EINECS:	208-477-9
Density:	1.172 g/cm³
Melting Point:	90 °C
Boiling Point:	691.6 °C at 760 mmHg
Flash Point:	372.1 °C
Solubility:	8.423ug/L(25 oC)
Appearance:	white or slightly yellow crystalline powder
Hazard Symbols:	Xn
Risk Codes:	40-36/37/38-20/21/22
Safety:	36/37-36-26
PSA:	121.45000
LogP:	7.85530

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Specification

The Chloramphenicol palmitate, with the CAS registry number 530-43-8, has the IUPAC name [(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] hexadecanoate. Its molecular formula is C₂₇H₄₂Cl₂N₂O₆ and its classification codes are Antibacterial; Antirickettsial; Reproductive Effect. Additionally, the product categories of this chemical are Bacteriostatic Alphabetic; CH Antibiotics; Antibiotics; C; Chemical Structure; Chromatography; Others Analytical Standards; Principle. This chemical is soluble in methanol, ethanol, chloroform, ether, benzene and it's used as antibiotic drugs.

Other characteristics of the Chloramphenicol palmitate can be summarised as followings: (1)ACD/LogP: 9.04; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): 9.04; (4)ACD/LogD (pH 7.4): 9.04; (5)ACD/BCF (pH 5.5): 1000000; (6)ACD/BCF (pH 7.4): 1000000; (7)ACD/KOC (pH 5.5): 1968133.25; (8)ACD/KOC (pH 7.4): 1966668.75; (9)#H bond acceptors: 8; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 23; (12)Polar Surface Area: 101.66 Å²; (13)Index of Refraction: 1.525; (14)Molar Refractivity: 146.92 cm³; (15)Molar Volume: 478.9 cm³; (16)Polarizability: 58.24×10^-24cm³; (17)Surface Tension: 44.9 dyne/cm; (18)Density: 1.172 g/cm³; (19)Flash Point: 372.1 °C; (20)Enthalpy of Vaporization: 106.43 kJ/mol; (21)Boiling Point: 691.6 °C at 760 mmHg; (22)Vapour Pressure: 4.43E-20 mmHg at 25°C.

Production method of this chemical: Adding α-methyl pyridine and benzene into pot, stirring it with chloramphenicol, maintaining the temperature 32-37 °C and dropping palm chloride, then continue to stir it for 4h and taking it into 15 times water, you can get the crude. The tasteless chloramphenicol could be made after washing, bleaching and recrystallization.

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1.SMILES: ClC(Cl)C(=O)N[C@@H]([C@H](O)c1ccc([N+]([O-])=O)cc1)COC(=O)CCCCCCCCCCCCCCC
2.InChI: InChI=1/C27H42Cl2N2O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-24(32)37-20-23(30-27(34)26(28)29)25(33)21-16-18-22(19-17-21)31(35)36/h16-19,23,25-26,33H,2-15,20H2,1H3,(H,30,34)/t23-,25-/m1/s1
3.InChIKey: PXKHGMGELZGJQE-ILBGXUMGBH

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	2640mg/kg (2640mg/kg)		Drugs in Japan Vol. 6, Pg. 248, 1982.