Products Categories
CAS No.: | 53439-91-1 |
---|---|
Name: | L-Phenylacetyl Carbinol |
Article Data: | 41 |
Molecular Structure: | |
Formula: | C9H10O2 |
Molecular Weight: | 150.177 |
Synonyms: | (S)-PAC;1S-FP;(S)-(+)-1-hydroxy-1-phenylpropan-2-one;(S)-1-hydroxy-1-phenylpropane-2-one;(S)-(+)-1-hydroxy-1-phenyl-2-propanone;(S)-1-hydroxy-1-phenyl-2-propanone;(1S)-1-hydroxy-1-phenylpropan-2-one; |
Density: | 1.119±0.06 g/cm3(Predicted) |
Boiling Point: | 253.3±20.0 °C(Predicted) |
PSA: | 37.30000 |
LogP: | 1.30900 |
1-Phenylpropane-1,2-dione
(S)-phenylacetylcarbinol
Conditions | Yield |
---|---|
With Arthrobacter sp. TS-15 recombinant pseudoephedrine dehydrogenase; NADH In aq. phosphate buffer at 25℃; pH=7.5; Kinetics; Green chemistry; Enzymatic reaction; enantioselective reaction; | 99% |
Conditions | Yield |
---|---|
With acetoin:dichlorophenolindophenol oxidoreductase from Bacillus licheniformis; thiamine diphosphate; magnesium sulfate In aq. phosphate buffer; dimethyl sulfoxide at 30℃; for 24h; pH=6.5; Catalytic behavior; Solvent; Benzoin Condensation; Green chemistry; Enzymatic reaction; enantioselective reaction; | 84% |
With thiamine diphosphate dependent acetoin:dichlorophenolindophenol oxidoreductase In aq. phosphate buffer; dimethyl sulfoxide at 30℃; for 48h; pH=6.5; Enzymatic reaction; |
(2S,6R,7S,8aR)-7-Allyl-6-benzyl-6,8a-dimethyl-3-methylene-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one
A
(S)-phenylacetylcarbinol
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In tetrahydrofuran; water Heating; | A n/a B 76% |
3-Hydroxy-3-methyl-2-butanone
benzaldehyde
B
(R)-1-hydroxy-1-phenyl-2-propanone
C
(S)-phenylacetylcarbinol
Conditions | Yield |
---|---|
With acetoin:dichlorophenolindophenol oxidoreductase from Bacillus licheniformis; thiamine diphosphate; magnesium sulfate In aq. phosphate buffer; dimethyl sulfoxide at 30℃; for 12h; pH=6.5; Benzoin Condensation; Green chemistry; Enzymatic reaction; enantioselective reaction; | A 2% B n/a C n/a |
methyl magnesium iodide
(R)-2-phenyl-2-(trimethylsiloxy)acetonitrile
A
(R)-1-hydroxy-1-phenyl-2-propanone
B
(S)-phenylacetylcarbinol
Conditions | Yield |
---|---|
With hydrogenchloride 1.) ether, reflux, 2 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; | |
With sulfuric acid 1.) ether, reflux, 4 h; 2.) 0 deg C, 8 h; Yield given. Multistep reaction. Yields of byproduct given; |
1-phenyl-2-trimethylsiloxy-1-propene
A
(R)-1-hydroxy-1-phenyl-2-propanone
B
(S)-phenylacetylcarbinol
Conditions | Yield |
---|---|
With (+)-(2S,8aS)-(camphorylsulfonyl)oxaziridine; methyllithium 1.) HMPA, THF, 0 deg C, 1h; 2.) -78 deg C; Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; |
1-phenyl-acetone
A
(R)-1-hydroxy-1-phenyl-2-propanone
B
(S)-phenylacetylcarbinol
Conditions | Yield |
---|---|
With (+)-(2S,8aS)-(camphorylsulfonyl)oxaziridine; lithium diisopropyl amide 1.) HMPA, THF, -78 deg C; 2.) HMPA, -78 deg C; Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; | |
With (+)-(2S,8aS)-(camphorylsulfonyl)oxaziridine; sodium hexamethyldisilazane 1.) THF, HMPA, -78 deg C, 30 min, 2.) -78 deg C, 15 min; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; | |
With Bacillus megaterium cytochrome P450-BM3 V78F mutant Reagent/catalyst; Enzymatic reaction; enantioselective reaction; | A n/a B n/a |
With Bacillus megaterium cytochrome P450-BM3 A328R mutant Catalytic behavior; Reagent/catalyst; Enzymatic reaction; enantioselective reaction; | A n/a B n/a |
1-Phenylpropane-1,2-dione
A
2-hydroxypropiophenone
B
(R)-1-hydroxy-1-phenyl-2-propanone
C
(S)-phenylacetylcarbinol
Conditions | Yield |
---|---|
With NAD; isopropyl alcohol In hexane; water Ambient temperature; PED alcohol dehydrogenase, phosphate buffer pH 7.1; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
(R)-1-hydroxy-1-phenyl-2-propanone
(S)-phenylacetylcarbinol
Conditions | Yield |
---|---|
In water at 30℃; Product distribution; racemization; |
(Z)-1-phenyl-2-(trimethylsiloxy)propene
A
(R)-1-hydroxy-1-phenyl-2-propanone
B
(S)-phenylacetylcarbinol
Conditions | Yield |
---|---|
With sodium hypochlorite; 4-Phenylpyridine 1-oxide; phosphate buffer; 5,5'-MeO-substituted (R,R)-(salen)Mn(III) In dichloromethane at 0℃; Mechanism; other silyl enol ethers and silyl ketene acetals; var. 5,5'-substituted (salen)Mn(III) complexes; | |
With sodium hypochlorite; 4-Phenylpyridine 1-oxide; phosphate buffer; 5,5'-MeO-substituted (R,R)-(salen)Mn(III) In dichloromethane at 0℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts; | |
With sodium hypochlorite; 4-Phenylpyridine 1-oxide; phosphate buffer; 5,5'-tBu-substituted (R,R)-(salen)Mn(III) In dichloromethane at 0℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |