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| CAS No.: | 53597-25-4 |
|---|---|
| Name: | PROTAMINE SULFATE |
| Molecular Structure: | |
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| Formula: | NULL |
| Molecular Weight: | 0 |
| Synonyms: | protaminesulfategradeXfromsalmon;salminesulphate;Protaminesulfate |
| EINECS: | 232-726-0 |
| Solubility: | H2O: 10 mg/mL |
| Appearance: | White to off-white amorphous powder |
| Safety: | 22-24/25 |
| PSA: | 0.00000 |
| LogP: | 0.00000 |
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Chemistry
Product Name: Protamine sulfate
EINECS: 232-726-0
Storage temp: Store at RT
Solubility: H2O: 10 mg/mL
Appearance: White to off-white amorphous powder
Synonyms: Clupeine sulfate ; Protamine sulfate (ex salmon) ; Protamine sulfate herring ; Protamine sulfate salmon ; Protamine sulfate, salmon milt ; Protamine sulfate salt ; Salmine ; Salmine sulfate
Uses
Protamine sulfate (53597-25-4) is usually administered to reverse the large dose of heparin administered during certain surgeries, especially heart surgery. It is also used in gene transfer and protein purification. It is also used in tissue cultures as a crosslinker for viral transduction.
Toxicity Data With Reference
| 1. | par-rat LDLo:120 mg/kg | PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 50 (1942),300. | ||
| 2. | ipr-gpg LDLo:120 mg/kg | PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 50 (1942),300. | ||
| 3. | ivn-gpg LDLo:120 mg/kg | PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 50 (1942),300. | ||
| 4. | par-gpg LDLo:60 mg/kg | PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 50 (1942),300. |
Safety Profile
Poison by intravenous, parenteral, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SOx and Na2O.
Specification
Protamine sulfate is a drug that reverses the anticoagulant effects of heparin by binding to it.Protamine was originally isolated from the sperm of sharks and other species of fish but is now produced primarily through recombinant biotechnology. It is a highly cationic peptide. It binds to heparin to form a stable ion pair which does not have anticoagulant activity; on its own, protamine has a weak anticoagulant effect. The complex of heparin and protamine is then removed and broken down by the reticuloendothelial system Dosage of Protamine sulfate (53597-25-4): Dosage for heparin reversal is 1mg protamine sulfate i.v. for every 100 IU of active heparin. In patients who are allergic to fish, it can cause significant histamine release resulting in hypotension and bronchoconstriction, and also causes pulmonary hypertension. Infusion should be slow to minimize these side effects. In large doses, protamine itself has some anticoagulant effect