Products Categories
| CAS No.: | 53617-35-9 |
|---|---|
| Name: | 4-(PIPERIDIN-4-YL)-MORPHOLINE |
| Article Data: | 18 |
| Molecular Structure: | |
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|
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| Formula: | C9H18N2O |
| Molecular Weight: | 170.255 |
| Synonyms: | Morpholine,4-(4-piperidyl)- (7CI);4-(Morpholin-4-yl)piperidine;4-Morpholinopiperidine; |
| EINECS: | 627-580-3 |
| Density: | 1.034 g/cm3 |
| Melting Point: | 40-43ºC |
| Boiling Point: | 256.341 °C at 760 mmHg |
| Flash Point: | 108.832 °C |
| Hazard Symbols: | R36/37/38:; |
| Risk Codes: | Xi:Irritant; ">  Xi:Irritant; |
| Safety: | 26-36-36/37/39 |
| PSA: | 24.50000 |
| LogP: | 1.94130 |
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- 548773-13-32-amino-4,6-dimethylpyrimidine-5-carboxylic acid
- 415967-79-2
4-(1-benzyl-piperidin-4-yl)-morpholine
- 53617-35-9
4-(piperidin-4-yl)morpholine
| Conditions | Yield |
|---|---|
| With palladium on activated charcoal; hydrogen In isopropyl alcohol at 80℃; under 3750.38 Torr; for 7h; Reagent/catalyst; Autoclave; | 100% |
| With palladium on activated charcoal; hydrogen In methanol at 20℃; under 3750.38 Torr; for 6h; | 97.6% |
| With hydrogen; palladium 10% on activated carbon In methanol at 20℃; under 2585.81 Torr; for 18h; | 93% |
| With hydrogenchloride; Pd(OH)2 In methanol | 932 mg (91%) |
| With hydrogenchloride; Pd(OH)2 In methanol | 932 mg (91%) |
- 53617-35-9
4-(piperidin-4-yl)morpholine
| Conditions | Yield |
|---|---|
| Stage #1: 4-(1-benzylpiperidin-4-yl)morpholine dihydrochloride With potassium carbonate In tert-butyl alcohol at 60℃; for 0.5h; pH=>11; Stage #2: With palladium 10% on activated carbon In tert-butyl alcohol at 50℃; for 8h; pH=>11; | 91.6% |
| Stage #1: 4-(1-benzylpiperidin-4-yl)morpholine dihydrochloride With potassium carbonate In water; tert-butyl alcohol at 45℃; Industrial scale; Stage #2: With hydrogen In tert-butyl alcohol at 60℃; under 3000.3 Torr; Industrial scale; | 88% |
- 125541-20-0
tert-butyl 4-(morpholin-4-yl)piperidine-1-carboxylate
- 53617-35-9
4-(piperidin-4-yl)morpholine
| Conditions | Yield |
|---|---|
| With trifluoroacetic acid In dichloromethane at 20℃; for 6h; | 79% |
| With trifluoroacetic acid In dichloromethane at 20℃; for 2h; | |
| With hydrogenchloride In methanol at 40℃; for 12h; | 1.52 g |
| With trifluoroacetic acid In dichloromethane at 20℃; | 3 g |
- 110-91-8
morpholine
- 3612-20-2
1-phenylmethyl-4-piperidone
A
- 53617-35-9
4-(piperidin-4-yl)morpholine
B
- 415967-79-2
4-(1-benzyl-piperidin-4-yl)-morpholine
| Conditions | Yield |
|---|---|
| With 10 wt% Pd(OH)2 on carbon; hydrogen at 80℃; under 3750.38 Torr; for 4h; Reagent/catalyst; Time; Autoclave; | A 19.7% B 77.5% |
- 110-91-8
morpholine
- 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one
- 53617-35-9
4-(piperidin-4-yl)morpholine
| Conditions | Yield |
|---|---|
| With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 0 - 20℃; for 16h; | 74% |
| With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 0 - 20℃; for 16h; | 74% |
| Stage #1: morpholine; N-tert-butyloxycarbonylpiperidin-4-one With titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 1h; Stage #2: With sodium cyanoborohydride In tetrahydrofuran; ethanol at 20℃; Stage #3: With water In tetrahydrofuran; ethanol for 0.5h; |
- 2767-91-1
4-morpholinopyridine
- 53617-35-9
4-(piperidin-4-yl)morpholine
| Conditions | Yield |
|---|---|
| With hydrogen; ruthenium(IV) oxide |
- 110-91-8
morpholine
- 67-63-0
isopropyl alcohol
- 29976-53-2
N-ethoxycarbonyl-4-piperidone
- 53617-35-9
4-(piperidin-4-yl)morpholine
| Conditions | Yield |
|---|---|
| With potassium hydroxide; sodium borohydrid; toluene-4-sulfonic acid In ethanol; toluene |
- 186650-77-1
4-(4-morpholinopiperidin-1-yl)benzonitrile
A
- 1194-02-1
4-fluorobenzonitrile
B
- 53617-35-9
4-(piperidin-4-yl)morpholine
- 334942-09-5
benzyl 4-morpholin-4-ylpiperidine-1-carboxylate
- 53617-35-9
4-(piperidin-4-yl)morpholine
| Conditions | Yield |
|---|---|
| With hydrogen |
- 3612-20-2
1-phenylmethyl-4-piperidone
- 53617-35-9
4-(piperidin-4-yl)morpholine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: toluene / 110 °C / Industrial scale 1.2: Raney nickel / 60 °C / 3000.3 Torr / Industrial scale 1.3: 50 °C / Industrial scale 2.1: potassium carbonate / water; tert-butyl alcohol / 45 °C / Industrial scale 2.2: 60 °C / 3000.3 Torr / Industrial scale View Scheme | |
| Multi-step reaction with 2 steps 1: hydrogen; platinum on activated charcoal / 8 h / 80 °C / 3750.38 Torr / Autoclave 2: hydrogen; palladium on activated charcoal / isopropyl alcohol / 7 h / 80 °C / 3750.38 Torr / Autoclave View Scheme | |
| Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 3 h / 20 °C 2: palladium on activated charcoal; hydrogen / methanol / 6 h / 20 °C / 3750.38 Torr View Scheme |
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Chemistry
Molecular Structure of 4-(PIPERIDIN-4-YL)-MORPHOLINE(53617-35-9):
IUPAC Name:4-piperidin-4-ylmorpholine
Molecular Formula:C9H18N2O
Molecular Weight:170.252020 g/mol
Melting Point:40-43 °C(lit.)
Density:1.033 g/cm3
Flash Point:108.8 °C
Enthalpy of Vaporization:49.39 kJ/mol
Boiling Point:256.3 °C at 760 mmHg
Vapour Pressure:0.0155 mmHg at 25 °C
Water Solubility:7.111e+005 mg/L at 25 °C
Synonyms of 4-(PIPERIDIN-4-YL)-MORPHOLINE(53617-35-9):
CHEMBRDG-BB 4004473;4-MORPHOLINOPIPERIDINE;AKOS BB-9182;TIMTEC-BB SBB010091;4-Morpholino-piperidin;4-(PIPERIDIN-4-YL)-MORPHOLINE >98%;4-MORPHOLINO-PIPERDINEDIHYDROCHLORIDE
Categories of 4-(PIPERIDIN-4-YL)-MORPHOLINE(53617-35-9):
Building Blocks;Heterocyclic Building Blocks;Piperidines
Safety Profile
Hazard Codes:Xi
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
WGK Germany:3
Hazard Note:Irritant