CAS No.54143-55-4,Flecainide Suppliers

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Basic Information

Molecular Structure:
CAS No.:	54143-55-4
Name:	Flecainide

Formula:	C₁₇H₂₀F₆N₂O₃
Molecular Weight:	414.348
Synonyms:	benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-;Flecaine;N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide;N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide;Benzamide,N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-;
EINECS:	258-997-5
Density:	1.286 g/cm³
Melting Point:	105-107 °C
Boiling Point:	434.9 °C at 760 mmHg
Flash Point:	216.8 °C
Appearance:	White crystalline powder
Hazard Symbols:	F,T
Risk Codes:	11-23/24/25-39/23/24/25
Safety:	7-16-36/37-45
PSA:	59.59000
LogP:	4.16040

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History

1、Flecainide acetate (Tambocor) is the focus of the book Deadly Medicine by Thomos J. Moore (Simon and Schuster 1995) which chronicles the drug's development, FDA approval and marketing history from 1972 to 1994. It asserts that neglect and cover-ups on the part of the pharmaceuticals, academics and FDA officials involved in its approval and marketing led to the deaths of 50,000 - 200,000 people who took the drug.
2、Flecainide(54143-55-4) was originally sold under the trade name Tambocor (manufactured by 3M pharmaceuticals). Flecainide went off-patent on February 10th, 2004, and is now available under the trade names Almarytm, Apocard, Ecrinal, and Flécaine.

Specification

1. Introduction of Flecainide

Flecainide, as one kind of white crystalline powder, odorless, little bitter taste, belongs to the Product Categories which include Intermediates & Fine Chemicals; Pharmaceuticals.

2. Toxicity of Flecainide

Due to the narrow therapeutic index of flecainide, physicians should be alert for signs of toxicity before life-threatening arrhythmias occur like torsade de pointes. While the toxic effects of flecainide are closely related to the plasma levels of the drug,it is infeasible to check the plasma concentration in an individual on a regular basis.Signs of flecainide toxicity include marked prolongation of the PR interval and widening of the QRS duration on the surface ECG. There may be signs and symptoms attributable to overt heart failure secondary to sudden decreased myocardial contractility.

3. Safety Information of Flecainide

Human systemic effects. When heated to decomposition it emits toxic vapors of NO_x and F⁻.
RIDADR 3249
HazardClass 6.1(b)
PackingGroup III

4. Use of Flecainide

Flecainide is used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart). It is used to treat a variety of cardiac arrhythmias including paroxysmal atrial fibrillation (episodic irregular heartbeat originating in the upper chamber of the heart), paroxysmal supraventricular tachycardia, and ventricular tachycardia (rapid rhythms of the lower chambers of the heart).