542-88-1

Molecular Formula: C₂H₄Cl₂O
Molar mass: 114.96 g/mol
EINECS: 208-832-8
Density: 1.609 g/cm³
Flash Point: 73 °C
Index of Refraction: 1.478
Boiling Point: 182.4 °C at 760 mmHg
Vapour Pressure: 1.1 mmHg at 25°C
Appearance: Colorless liquid
Solubility: With ethanol, ethyl ether immiscibility. With water down into Hydrogen chloride and Formaldehyde
Product categories of Bis(chloromethyl)ether (542-88-1): Organics;Pharmacetical
Structure of Bis(chloromethyl)ether (542-88-1):

XLogP3-AA: 1.5
H-Bond Donor: 0
H-Bond Acceptor: 1
Systematic Name: Dichloro-(dichloromethoxy)methane 
SMILES: ClC(Cl)OC(Cl)Cl 
InChI: InChI=1/C2H2Cl4O/c3-1(4)7-2(5)6/h1-2H 
InChIKey: HKYGSMOFSFOEIP-UHFFFAOYAJ 
Std. InChI: InChI=1S/C2H2Cl4O/c3-1(4)7-2(5)6/h1-2H 
Std. InChIKey: HKYGSMOFSFOEIP-UHFFFAOYSA-N

 Bis(chloromethyl)ether (542-88-1) has been used for the intermediate of  the drug Elimination tumor mustard , Eight nitrogen paraxylene ether , and Pairs of PAM ;and  is also the intermediate of Vitamin B2 (Synthesis of 3,4 - Dimethyl aniline raw materials).

By chlorination of Paraformaldehyde .

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 1 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man 7 (1987),p. 131.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man 4 (1974),p. 231.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man 4 (1974),p. 231.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Community Right-To-Know List. EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.

Confirmed human carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by inhalation, ingestion, and skin contact. Human systemic effects by inhalation: irritation of the conjunctiva, unspecified nasal and respiratory effects. Human mutation data reported. A dangerous fire hazard. When heated to decomposition it emits very toxic fumes of Cl⁻. See also ETHERS.
 

Hazard Codes: T+
Risk Statements:
10:  Flammable
22:  Harmful if swallowed
24:  Toxic in contact with skin
25:  Toxic if swallowed
26:  Very Toxic by inhalation
36:  Irritating to the eyes
37:  Irritating to the respiratory system
38:  Irritating to the skin
40:  Limited evidence of a carcinogenic effect
Safety Statements:
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing 
37:  Wear suitable gloves
39:  Wear eye/face protection
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
53:  Avoid exposure - obtain special instruction before use

OSHA PEL: OSHA: Cancer Suspect Agent
ACGIH TLV: TWA 0.001 ppm; Confirmed Human Carcinogen
DFG MAK: Human Carcinogen
DOT Classification:  6.1; Label: Poison

For occupational chemical analysis use OSHA: #10.

 Bis(chloromethyl)ether (542-88-1) also can be called Dichloromethyl ether ; Chloromethyl ether ; Dibutylene tetrafurfural  ; Oxybis(chloromethane) ; alpha,alpha-Dichloromethyl ether ;and Ether, bis(dichloromethyl) .