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| CAS No.: | 547-32-0 |
|---|---|
| Name: | Sodium sulfadiazine |
| Article Data: | 4 |
| Molecular Structure: | |
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|
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| Formula: | C10H9N4NaO2S |
| Molecular Weight: | 273.271 |
| Synonyms: | Benzenesulfonamide,4-amino-N-2-pyrimidinyl-, monosodium salt (9CI);Sodium, (N1-2-pyrimidinylsulfanilamido)-(7CI);Sulfadiazine, sodium deriv. (6CI);Sulfanilamide, N1-2-pyrimidinyl-,monosodium salt (8CI);2-Sulfanilamidopyrimidine sodium salt;Monosodium2-sulfanilamidopyrimidine;Sodium 2-sulfanilamidopyrimidine;Sodium sulfapyrimidine;Sulfadiazine sodium;Sulfapyrimidine sodium; |
| EINECS: | 208-919-0 |
| Density: | 1.496g/cm3 |
| Boiling Point: | 512.6oC at 760 mmHg |
| Flash Point: | 263.8oC |
| Appearance: | white to off-white crystalline powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 22-36/37/38-42/43 |
| Safety: | 22-26-36/37-45 |
| Transport Information: | UN 3249 |
| PSA: | 97.56000 |
| LogP: | 2.38040 |
- 81281-59-67-Benzylideneaminotheophylline
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- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
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- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 717878-06-31-(4-fluorophenyl)-4-nitro-1H-imidazole
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 548773-13-32-amino-4,6-dimethylpyrimidine-5-carboxylic acid
| Conditions | Yield |
|---|---|
| With sodium hydroxide In ethanol; water Heating; |
- 12080-32-9
dichloro(1,5-cyclooctadiene)platinum(ll)
- 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]
- 39234-21-4
sodium N-methyl-N-phenyldithiocarbamate
| Conditions | Yield |
|---|---|
| Stage #1: dichloro(1,5-cyclooctadiene)platinum(ll); poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)] In water for 1h; Reflux; Stage #2: sodium N-methyl-N-phenyldithiocarbamate In water for 3h; Reflux; | 97% |
- 7440-22-4
silver
- 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]
- 22199-08-2
silver sulfadiazine
| Conditions | Yield |
|---|---|
| With sodium nitrate; nitric acid In water for 0.1h; Electrochemical reaction; Green chemistry; | 97% |
- 12080-32-9
dichloro(1,5-cyclooctadiene)platinum(ll)
- 13074-29-8
(N-ethyl-N'-phenyl-dithiocarbamato) sodium
- 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]
| Conditions | Yield |
|---|---|
| Stage #1: dichloro(1,5-cyclooctadiene)platinum(ll); poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)] In water for 1h; Reflux; Stage #2: (N-ethyl-N'-phenyl-dithiocarbamato) sodium In water for 3h; Reflux; | 92% |
| Conditions | Yield |
|---|---|
| In methanol for 4h; Reflux; | 89.1% |
- 298-96-4
triphenyltetrazolium chloride
- 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]
| Conditions | Yield |
|---|---|
| In methanol; water at 20℃; for 2h; | 88% |
- 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]
- 1096051-46-5
Zn(sulfadiazine)2(H2O)2
| Conditions | Yield |
|---|---|
| In water aq. Zn salt added to aq. Na salt of sulfadiazine; soln. stirred at 40°C for 3 h; cooled to room temp.; filtered under vac., washed with water; dried over CaCl2; elem. anal.; | 87% |
- 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]
- 1096051-46-5
Zn(sulfadiazine)2(H2O)2
| Conditions | Yield |
|---|---|
| In water aq. Zn salt added to aq. Na salt of sulfadiazine; soln. stirred at 40°C for 3 h; cooled to room temp.; filtered under vac., washed with water; dried over CaCl2; | 87% |
- 21264-30-2, 90243-59-7, 14592-56-4
dichloro bis(acetonitrile) palladium(II)
- 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]
- 39234-21-4
sodium N-methyl-N-phenyldithiocarbamate
| Conditions | Yield |
|---|---|
| Stage #1: dichloro bis(acetonitrile) palladium(II); poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)] In water for 1h; Reflux; Stage #2: sodium N-methyl-N-phenyldithiocarbamate In water for 3h; Reflux; | 85% |
- 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]
| Conditions | Yield |
|---|---|
| In methanol; water Reflux; | 85% |
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Specification
This chemical is called Sulfadiazine Sodium, and its CAS registry number is 547-32-0. With the molecular formula of C10H9N4NaO2S, its classification codes are Antibacterial; Drug / Therapeutic Agent; Mutation data; Reproductive Effect. Additionally, it's used for cure sulfonamide, susceptible infections and it can also be used for T. gondii infection. However, it should be stored at 2-8°C.
Other characteristics of the Sulfadiazine Sodium can be summarised as followings: (1)#H bond acceptors: 6; (2)#H bond donors: 3; (3)#Freely Rotating Bonds: 2; (4)Polar Surface Area: 106.35 Å2.
When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. It may cause sensitization by inhalation and skin contacting. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 1747mg/kg (1747mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 17, 1944. | |
| mouse | LD50 | intravenous | 540mg/kg (540mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 94, Pg. 338, 1953. | |
| mouse | LD50 | oral | 1700mg/kg (1700mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 94, Pg. 338, 1953. | |
| mouse | LD50 | subcutaneous | 1408mg/kg (1408mg/kg) | Acta Medica Scandinavica, Supplement. Vol |