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547-91-1

Basic Information
CAS No.: 547-91-1
Name: Chiniofon
Molecular Structure:
Molecular Structure of 547-91-1 (Chiniofon)
Formula: C9H6 I N O4 S
Molecular Weight: 351.121
Synonyms: 5-Sulfo-7-iodo-8-hydroxyquinoline;5-Sulfo-7-iodo-8-quinolinol; 7-Iodo-5-sulfonic acid-8-hydroxyquinoline; 7-Iodo-8-hydroxylquinoline-5-sulfonicacid; 7-Iodo-8-hydroxyquinoline-5-sulfonic acid; 7-Iodo-8-quinolinol-5-sulfonicacid; 7-Iodooxine-5-sulfonic acid; 8-Hydroxy-7-iodoquinoline-5-sulfonic acid;Ferron; Ferron (analytical reagent); Loretin; Meditrene; NSC 3784; Quiniophen;Yellon
EINECS: 208-938-4
Density: 2.193g/cm3
Melting Point: 269-270 ºC
Solubility: slight
Appearance: yellow-green powder
Hazard Symbols:
Risk Codes: R34   
Safety: Moderately toxic by ingestion, intravenous, and intramuscular routes. When heated to decomposition it emits toxic fumes of NOx and SOx. Note: The name Anayodin is also used to designate sodium iodide.
Transport Information: UN 2585
PSA: 95.87000
LogP: 2.87250
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Chemistry

Product Name: 7-Iodo-8-hydroyquinoline-5-sulfonic acid (CAS NO.547-91-1)


Molecular Formula: C9H6INO4S
Molecular Weight: 351.12g/mol
Mol File: 547-91-1.mol
Einecs: 208-938-4
Appearance: Yellow-green powder
Melting Point: 269-270 °C (dec.)(lit.)
Density: 2.193 g/cm3
Surface Tension: 87.7 dyne/cm
XLogP3-AA: 1.2
H-Bond Donor: 2
H-Bond Acceptor: 5
Product Categories: Haloquinolines; Hydroxyquinolines; Quinolines

Uses

 7-Iodo-8-hydroyquinoline-5-sulfonic acid (CAS NO.547-91-1) is used for anti-amoebic drug. It belongs to halogenated 8 - hydroxy quinoline class. Such anti-amebic drugs by inhibiting the intestinal anti-amebic symbiotic bacteria play a role in production efficiency of amoebic dysentery, amoebic protozoa of the intestine had no effect outside. In recent years, foreign coverage of the drugs can cause subacute optic neuropathy, so the drug in Japan and the United States has been disabled.

Production

 7-Iodo-8-hydroyquinoline-5-sulfonic acid (CAS NO.547-91-1) is by the 8 - hydroxyquinoline by oleum sulfonation, iodine tablets and iodized sodium hypochlorite derived.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 4gm/kg (4000mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 43, Pg. 495, 1954.
rat LDLo intramuscular 1gm/kg (1000mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 63, Pg. 122, 1938.
rat LDLo intravenous 500mg/kg (500mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 63, Pg. 122, 1938.
rat LDLo oral 800mg/kg (800mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 3, Pg. 44, 1948.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Moderately toxic by ingestion, intravenous, and intramuscular routes. When heated to decomposition it emits toxic fumes of NOx and SOx. Note: The name Anayodin is also used to designate sodium iodide.
Safety Information of 7-Iodo-8-hydroyquinoline-5-sulfonic acid (CAS NO.547-91-1):
Hazard Codes: C
Risk Statements: 34 
34:  Causes burns
Safety Statements: 26-36/37/39-45
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing  
37:  Wear suitable gloves  
39:  Wear eye/face protection 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

Specification

 7-Iodo-8-hydroyquinoline-5-sulfonic acid ,its CAS NO. is 547-91-1,the synonyms is 5-Quinolinesulfonicacid,8-hydroxy-7-iodo- ; 8-Hydroxy-7-iodo-5-quinolinesulfonate ; 8-Hydroxy-7-iodo-5-quinolinesulfonicaci ; Ferron(analyticalreagent) ; Meditrene ; Quiniophen ; Yellon .