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| CAS No.: | 5470-11-1 |
|---|---|
| Name: | Hydroxylamine hydrochloride |
| Molecular Structure: | |
|
|
|
| Formula: | H3NO.HCl |
| Molecular Weight: | 69.4909 |
| Synonyms: | Hydroxylamine,hydrochloride (8CI,9CI);Hydroxyammonium chloride;Hydroxylamine chloride;Hydroxylamine chlorohydrate;Hydroxylammonium chloride;Oxammonium hydrochloride;hydroxylamine hydrochloride;Hydroxylamine HCl; |
| EINECS: | 226-798-2 |
| Density: | 1.67 g/mL at 25 °C |
| Melting Point: | 155-158 °C |
| Boiling Point: | 56.5 °C at 760 mmHg |
| Solubility: | 560 g/L (20 °C) in water |
| Appearance: | Colorless or off-white crystalline solid |
| Hazard Symbols: |
 Xn,  N
|
| Risk Codes: | 22-36/38-43-48/22-50 |
| Safety: | 22-24-37-61 |
| Transport Information: | UN 2923 8/PG 2 |
| PSA: | 46.25000 |
| LogP: | 0.83660 |
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| Conditions | Yield |
|---|---|
| With hydrogenchloride In methanol byproducts: NH4Cl, N2H5Cl; (N2); HCl bubbled through a soln. of the Mo-complex at 0°C for 15 min; soln. stirred for 1.5 h at room temp.; N2 bubbled through the suspn. for 15 min; ppt. filtered, washed with methanol and diethyl ether; recrystd. from hot THF; | A 93% B n/a |
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ethyl nitrate
A
- 5470-11-1
hydroxylamine hydrochloride
B
- 7664-41-7
ammonia
C
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tin(IV) chloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride In hydrogenchloride byproducts: C2H5OH, H2O; in concd. HCl soln.; evapn. of the alcohol,diluting with water,pptg. of the Sn with H2S,evapn. and crystn. from alcohol; | A 90% B <1 C n/a |
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[Ni(II)(salicylaldehyde oximate)2]
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ethylenediamine hydrochloride
B
- 5470-11-1
hydroxylamine hydrochloride
| Conditions | Yield |
|---|---|
| In methanol stirring the soln. for 30 min between room temp. and 60°C, pptn.; filtration, washing with water, recrystn. from acetone; | A 90% B n/a |
| Conditions | Yield |
|---|---|
| With hydrogenchloride; sulfur dioxide In water byproducts: H2SO4; react. in water contg. ice and K-acetate leading SO2 into it,mixing,at 0°C;filtering,washing with 0.5 n HCl,hydrolysis at 100°C,for 2h; pptg. of H2SO4 with BaCl2,filtering,evapn.; | 85% |
| Conditions | Yield |
|---|---|
| In sulfuric acid Electrolysis; mixing dild. HCl with dild. HNO3 in an amalgated lead cell as cathode under applying lead anode (anode liquid: dild. H2SO4), 15°C, current: 50 A and 25 V; evapn., then cooling, removing of NH4Cl by treating with cold abs. alc., recrystn. from alcohol; | A 80% B n/a |
| In sulfuric acid aq. H2SO4; Electrolysis; mixing dild. HCl with dild. HNO3 in an amalgated lead cell as cathode under applying lead anode (anode liquid: dild. H2SO4), 15°C, current: 50 A and 25 V; evapn., then cooling, removing of NH4Cl by treating with cold abs. alc., recrystn. from alcohol; | A 80% B n/a |
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hydrogen sulfide
- 2696-92-6
nitrosylchloride
A
- 5470-11-1
hydroxylamine hydrochloride
B
- 7704-34-9
sulfur
| Conditions | Yield |
|---|---|
| In neat (no solvent) byproducts: sulfur chloride, HCl, NO; further by-products: N2, NH4Cl;; | A 0% B n/a |
| In neat (no solvent) byproducts: sulfur chloride, HCl, NO; further by-products: N2, NH4Cl;; | A 0% B n/a |
- 5470-11-1
hydroxylamine hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride byproducts: HCO2H; under cooling; | |
| With HCl byproducts: HCO2H; under cooling; |
| Conditions | Yield |
|---|---|
| In water excess of BaCl2; evapn., residue extrd. in a Soxhlet apparate with abs. alcohol, crystn.; | |
| In water excess of BaCl2; evapn., residue extrd. in a Soxhlet apparate with abs. alcohol, crystn.; |
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mercury fulminate
- 5470-11-1
hydroxylamine hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride with cooled,concd. HCl; evapn.,dissolving in water,removing of the Hg with H2S,evapn.,crystn.; |
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Chemistry
Molecular Structure of Hydroxylamine hydrochloride (CAS NO.5470-11-1):
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IUPAC Name: Hydroxylamine hydrochloride
Molecular Formula: H3NO.HCl
Molecular Weight: 69.49
EINECS: 226-798-2
H-Bond Donor: 3
H-Bond Acceptor: 2
storage temp.: Store at RT.
Water Solubility :560 g/L (20 °C)
Sensitive: Hygroscopic
Density: 1.67 g/mL at 25 °C(lit.)
Melting Point: 155-157 °C (dec.)(lit.)
Enthalpy of Vaporization: 34.9 kJ/mol
Boiling Point: 56.5 °C at 760 mmHg
Vapour Pressure: 179 mmHg at 25 °C
Appearance: Colorless or off-white crystalline solid
Classification Code: Mutation data
Canonical SMILES: NO.Cl
InChI: InChI=1S/ClH.H3NO/c;1-2/h1H;2H,1H2
InChIKey: WTDHULULXKLSOZ-UHFFFAOYSA-N
Stability: Substances to be avoided include strong oxidizing agents. Heating above 115 C may cause explosion; do not store above 65C. Moisture and air sensitive.
Uses
Hydroxylamine hydrochloride (CAS NO.5470-11-1) is used in organic synthesis for preparation of oximes and hydroxamic acids from carboxylic acids, N- and O- substituted hydroxyamines, and addition reactions of carbon-carbon double bond. It is also used as a fixative for textile dyes, auxiliary in some dyeing processes, as a metal extraction and flotation aid, as an antioxidant in fatty acids and soaps, and as a color stabilizer and emulsion additive in color films. Hydroxylamine hydrochloride can be used to remove bromine and polybromide from the solution.
In surface treatments, Hydroxylamine hydrochloride is used in the preparation of anti-skinning agents, corrosion inhibitors, and cleaner additives. It is also a starting material for pharmaceuticals and agrochemicals manufacturing. In the rubber and plastics industries, it is an antioxidant, vulcanization accelerator, and radical scavenger.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | subcutaneous | 70mg/kg (70mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
| mouse | LD50 | intraperitoneal | 10mg/kg (10mg/kg) | National Technical Information Service. Vol. AD277-689, | |
| mouse | LD50 | oral | 408mg/kg (408mg/kg) | Acta Pharmacologica et Toxicologica. Vol. 6, Pg. 285, 1950. | |
| mouse | LD50 | subcutaneous | 125mg/kg (125mg/kg) | Acta Biologica et Medica Germanica. Vol. 21, Pg. 635, 1968. | |
| rat | LD50 | oral | 141mg/kg (141mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | National Technical Information Service. Vol. OTS0555279, |
Consensus Reports
Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Safety Profile
Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx.
Safety Information of Hydroxylamine hydrochloride (CAS NO.5470-11-1):
Hazard Codes: 
Xn,
N
Risk Statements: 22-36/38-43-48/22-50
R22:Harmful if swallowed.
R36/38:Irritating to eyes and skin.
R43:May cause sensitization by skin contact.
R48/22:Harmful: danger of serious damage to health by prolonged exposure if swallowed.
R50:Very toxic to aquatic organisms.
Safety Statements: 22-24-37-61
S22:Do not breathe dust.
S24:Avoid contact with skin.
S37:Wear suitable gloves.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 2923 8/PG 2
WGK Germany: 3
RTECS: NC3675000
F: 21
HazardClass: 8
PackingGroup: III
Specification
Hydroxylamine hydrochloride (CAS NO.5470-11-1), its Synonyms are Hydroxyamine hydrochloride ; Hydroxyammonium chloride ; Hydroxylamine chloride ; Hydroxylamine chloride (1:1) ; Hydroxylamine-1-hydrochloride ; Hydroxylammonium chloride ; Oxammonium hydrochloride .