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| CAS No.: | 54965-21-8 |
|---|---|
| Name: | Albendazole |
| Molecular Structure: | |
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|
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| Formula: | C12H15N3O2S |
| Molecular Weight: | 265.336 |
| Synonyms: | Albendazole Bolus/tablet;O-Methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate;Albendazole (CP/USP);Albenza (TN);Eskazole;Vermitan;(5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester;Carbamic acid,[5-(propylthio)-1Hbenzimidazol- 2-yl]-,methyl ester;Methyl 5-(propylthio)-2-benzimidazolecarbamate;SKF-62979;Albendazole [USAN:BAN:INN:JAN];Albendazol [INN-Spanish];Bilutac;Carbamic acid, [5- (propylthio)-1H-benzimidazol-2-yl]-, methyl ester;Albenza;methyl N-(5-propylsulfanyl-3H-benzoimidazol-2-yl)carbamate;Zental;Albendazole (JAN/USP);((Propylthio)-5 1H-benzimidazolyl-2) carbamate de methyle [French];Proftril;[5-(Propythio)-1H-benzimidazol-2-yl]carbamic acid methyl ester;SKF 62979;Prestwick_675;SKandF 62979;Zentel;Albendazole cp2005; |
| EINECS: | 259-414-7 |
| Density: | 1.3 g/cm3 |
| Melting Point: | 208-210 °C |
| Solubility: | 0.75mg/L(209 oC) |
| Appearance: | Colourless crystalline solid |
| Hazard Symbols: |
|
| Risk Codes: | 61-36/37/38 |
| Safety: | 53-45-37/39-26 |
| PSA: | 92.31000 |
| LogP: | 3.31630 |
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| Conditions | Yield |
|---|---|
| With caesium carbonate In N,N-dimethyl-formamide at 120℃; for 0.216667h; Sealed tube; Microwave irradiation; | 86% |
| With sodium hydroxide | 26.95 g |
- 66608-52-4
4-(propylthio)-1,2-phenylenediamine
- 40943-37-1
O-methyl-N-(methoxycarbonyl)-isourea
- 54965-21-8
Albendazole
| Conditions | Yield |
|---|---|
| With ethylenediaminetetraacetic acid; acetic acid In methanol at 110℃; for 5h; Inert atmosphere; Reflux; | 65.1% |
| Conditions | Yield |
|---|---|
| With potassium carbonate; sodium thiosulfate; copper dichloride In water at 135℃; for 20h; | 58% |
- 54029-12-8, 122063-20-1, 122063-21-2
ricobendazole
- 54965-21-8
Albendazole
| Conditions | Yield |
|---|---|
| With aluminum (III) chloride; tetrabutyl-ammonium chloride; aluminium In 1,2-dichloro-ethane at 20℃; for 6h; Electrolysis; Inert atmosphere; Green chemistry; | 74% |
| With 1,2,3-trimethoxybenzene; oxalyl dichloride In chloroform at 0℃; for 0.00166667h; Inert atmosphere; chemoselective reaction; | 73% |
- 21729-98-6
methyl-N-cyano carbamate
- 66608-52-4
4-(propylthio)-1,2-phenylenediamine
- 54965-21-8
Albendazole
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water; acetone at 85℃; Large scale; | 520 kg |
| With hydrogenchloride In water at 80℃; for 0.5h; pH=4 - 5; | 26.05 g |
- 66608-52-4
4-(propylthio)-1,2-phenylenediamine
- 54965-21-8
Albendazole
| Conditions | Yield |
|---|---|
| Stage #1: 4-(propylthio)-1,2-phenylenediamine With hydrogenchloride In water; acetone at 80 - 85℃; Industry scale; Stage #2: sodium salt of cyanocarbamic acid methyl ester at 20 - 85℃; pH=4 - 4.5; |
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- 141-53-7Sodium formate
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- 9003-39-8Povidone
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Chemistry
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IUPAC Name: Methyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate
Molecular Formula: C12H15N3O2S
Molecular Weight: 265.33
EINECS : 259-414-7
Product Category: Active Pharmaceutical Ingredients;API;Intermediates & Fine Chemicals;Veterinaries;Miscellaneous Compounds
Melting point: 208-210 °C
Storage tempreture: 0-6 °C
Index of Refraction: 1.634
Molar Refractivity: 72.69 cm3
Molar Volume: 203.1 cm3
Surface Tension: 61.9 dyne/cm
Density of Albendazole (CAS NO.54965-21-8): 1.3 g/cm3
Uses
Albendazole (CAS NO.54965-21-8) is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. It is effective against: flatworms, flukes/trematodes, tapeworm/cestodes, echinococcosis, nematodes, hookworms, roundworms, whipworms, and threadworms or pinworms. In Africa, albendazole is being used to treat lymphatic filariasis as part of efforts to stop transmission of the disease. In Brazil and other countries it is used against giardiasis.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| hamster | LD50 | oral | > 10gm/kg (10000mg/kg) | Drugs in Japan Vol. -, Pg. 99, 1995. | |
| mouse | LD50 | oral | 1500mg/kg (1500mg/kg) | Acta Leidensia. Vol. 57, Pg. 201, 1989. | |
| rat | LD50 | intravenous | 265mg/kg (265mg/kg) | Drugs in Japan Vol. -, Pg. 99, 1995. | |
| rat | LD50 | oral | 2400mg/kg (2400mg/kg) | Annales Pharmaceutiques Francaises. Vol. 40, Pg. 55, 1982. | |
| women | TDLo | oral | 256mg/kg/16D (256mg/kg) | BLOOD: APLASTIC ANEMIA | American Journal of Hematology. Vol. 53, Pg. 53, 1996. |
Safety Profile
Hazard Codes: 
T
Risk Statements: 61-36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
R61:May cause harm to the unborn child.
Safety Statements: 53-45-37/39-26
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53:Avoid exposure - obtain special instructions before use.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany 2
RTECS FD1100000
Specification
Albendazole , its cas register number is 54965-21-8. It also can be called Methyl 5-propylthio-2-benzimidazolecarbamate . It may cause dizziness, headache, fever, nausea, vomiting, or temporary hair loss. It is colourless crystalline solid.