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Basic Information

Molecular Structure:
CAS No.:	54965-21-8
Name:	Albendazole
Article Data:	19
Cas Database

Formula:	C₁₂H₁₅N₃O₂S
Molecular Weight:	265.336
Synonyms:	Albendazole Bolus/tablet;O-Methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate;Albendazole (CP/USP);Albenza (TN);Eskazole;Vermitan;(5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester;Carbamic acid,[5-(propylthio)-1Hbenzimidazol- 2-yl]-,methyl ester;Methyl 5-(propylthio)-2-benzimidazolecarbamate;SKF-62979;Albendazole [USAN:BAN:INN:JAN];Albendazol [INN-Spanish];Bilutac;Carbamic acid, [5- (propylthio)-1H-benzimidazol-2-yl]-, methyl ester;Albenza;methyl N-(5-propylsulfanyl-3H-benzoimidazol-2-yl)carbamate;Zental;Albendazole (JAN/USP);((Propylthio)-5 1H-benzimidazolyl-2) carbamate de methyle [French];Proftril;[5-(Propythio)-1H-benzimidazol-2-yl]carbamic acid methyl ester;SKF 62979;Prestwick_675;SKandF 62979;Zentel;Albendazole cp2005;
EINECS:	259-414-7
Density:	1.3 g/cm³
Melting Point:	208-210 °C
Solubility:	0.75mg/L(209 oC)
Appearance:	Colourless crystalline solid
Hazard Symbols:
Risk Codes:	61-36/37/38
Safety:	53-45-37/39-26
PSA:	92.31000
LogP:	3.31630

Synthetic route

: 6-(propylthio)-1H-benzo[d]imidazol-2-amine

: 79-22-1
methyl chloroformate

: 54965-21-8
Albendazole

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 120℃; for 0.216667h; Sealed tube; Microwave irradiation;	86%
With sodium hydroxide	26.95 g

: 66608-52-4
4-(propylthio)-1,2-phenylenediamine

: 40943-37-1
O-methyl-N-(methoxycarbonyl)-isourea

: 54965-21-8
Albendazole

Conditions

Conditions	Yield
With ethylenediaminetetraacetic acid; acetic acid In methanol at 110℃; for 5h; Inert atmosphere; Reflux;	65.1%

: 106-94-5
propyl bromide

: 40483-97-4
methyl 5-nitrobenzoimidazole-2-carbamate

: 54965-21-8
Albendazole

Conditions

Conditions	Yield
With potassium carbonate; sodium thiosulfate; copper dichloride In water at 135℃; for 20h;	58%

: 54029-12-8, 122063-20-1, 122063-21-2
ricobendazole

: 54965-21-8
Albendazole

Conditions

Conditions	Yield
With aluminum (III) chloride; tetrabutyl-ammonium chloride; aluminium In 1,2-dichloro-ethane at 20℃; for 6h; Electrolysis; Inert atmosphere; Green chemistry;	74%
With 1,2,3-trimethoxybenzene; oxalyl dichloride In chloroform at 0℃; for 0.00166667h; Inert atmosphere; chemoselective reaction;	73%

: 21729-98-6
methyl-N-cyano carbamate

: 66608-52-4
4-(propylthio)-1,2-phenylenediamine

: 54965-21-8
Albendazole

Conditions

Conditions	Yield
With hydrogenchloride In water; acetone at 85℃; Large scale;	520 kg
With hydrogenchloride In water at 80℃; for 0.5h; pH=4 - 5;	26.05 g

: sodium salt of cyanocarbamic acid methyl ester

: 66608-52-4
4-(propylthio)-1,2-phenylenediamine

: 54965-21-8
Albendazole

Conditions

Conditions	Yield
Stage #1: 4-(propylthio)-1,2-phenylenediamine With hydrogenchloride In water; acetone at 80 - 85℃; Industry scale; Stage #2: sodium salt of cyanocarbamic acid methyl ester at 20 - 85℃; pH=4 - 4.5;

Raw Materials

88-74-4

420-04-2

Downstream Products

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Chemistry

IUPAC Name: Methyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate
Molecular Formula: C₁₂H₁₅N₃O₂S
Molecular Weight: 265.33
EINECS : 259-414-7
Product Category: Active Pharmaceutical Ingredients;API;Intermediates & Fine Chemicals;Veterinaries;Miscellaneous Compounds
Melting point: 208-210 °C
Storage tempreture: 0-6 °C
Index of Refraction: 1.634
Molar Refractivity: 72.69 cm³
Molar Volume: 203.1 cm³
Surface Tension: 61.9 dyne/cm
Density of Albendazole (CAS NO.54965-21-8): 1.3 g/cm³

Uses

Albendazole (CAS NO.54965-21-8) is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. It is effective against: flatworms, flukes/trematodes, tapeworm/cestodes, echinococcosis, nematodes, hookworms, roundworms, whipworms, and threadworms or pinworms. In Africa, albendazole is being used to treat lymphatic filariasis as part of efforts to stop transmission of the disease. In Brazil and other countries it is used against giardiasis.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
hamster	LD50	oral	> 10gm/kg (10000mg/kg)		Drugs in Japan Vol. -, Pg. 99, 1995.
mouse	LD50	oral	1500mg/kg (1500mg/kg)		Acta Leidensia. Vol. 57, Pg. 201, 1989.
rat	LD50	intravenous	265mg/kg (265mg/kg)		Drugs in Japan Vol. -, Pg. 99, 1995.
rat	LD50	oral	2400mg/kg (2400mg/kg)		Annales Pharmaceutiques Francaises. Vol. 40, Pg. 55, 1982.
women	TDLo	oral	256mg/kg/16D (256mg/kg)	BLOOD: APLASTIC ANEMIA	American Journal of Hematology. Vol. 53, Pg. 53, 1996.

Safety Profile

Hazard Codes: Toxic T
Risk Statements: 61-36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
R61:May cause harm to the unborn child.
Safety Statements: 53-45-37/39-26
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53:Avoid exposure - obtain special instructions before use.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany 2
RTECS FD1100000

Specification

Albendazole , its cas register number is 54965-21-8. It also can be called Methyl 5-propylthio-2-benzimidazolecarbamate . It may cause dizziness, headache, fever, nausea, vomiting, or temporary hair loss. It is colourless crystalline solid.