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CAS No.: | 55-18-5 | |
---|---|---|
Name: | N-NITROSODIETHYLAMINE | |
Article Data: | 97 | |
Molecular Structure: | ||
Formula: | C4H10 N2 O | |
Molecular Weight: | 102.136 | |
Synonyms: | Diethylamine,N-nitroso- (6CI,8CI); DEN; DEN (mutagen); DENA; Diethylnitrosamide;Diethylnitrosamine; Diethylnitrosoamine; N,N-Diethylnitrosoamine;N-Ethyl-N-nitrosoethanamine; N-Nitroso-N,N-diethylamine; N-Nitrosodiethylamine;NDEA; NSC 132; Nitrosodiethylamine | |
EINECS: | 200-226-1 | |
Density: | 0.95g/cm3 | |
Melting Point: | <25℃ | |
Boiling Point: | 173.9°Cat760mmHg | |
Flash Point: | 59°C | |
Solubility: |
substantial
Stability
Toxicology
|
|
Appearance: | yellow liquid | |
Hazard Symbols: | T,F | |
Risk Codes: | R45; R22; R39/23/24/25; R23/24/25; R11 | |
Safety: | Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A transplacental carcinogen. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS and AMINES. | |
Analytical Methods: | For occupational chemical analysis use OSHA: #27 or NIOSH: Nitrosamines, 2522. |
|
PSA: | 32.67000 | |
LogP: | 1.00960 |
Conditions | Yield |
---|---|
With [NO(1+)*18-crown-6*H(NO3)2(1-)] In dichloromethane at 20℃; for 0.0833333h; | 100% |
With magnesium hydrogen sulfate; silica gel; sodium nitrite In dichloromethane at 20℃; for 1h; Nitrosation; | 98% |
With aluminium trichloride; silica gel; sodium nitrite In dichloromethane at 20℃; for 0.5h; Nitrosation; | 98% |
Conditions | Yield |
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With tin(IV) chloride; sodium nitrite In tetrachloromethane for 14h; Heating; | 96% |
With bromine; triphenylphosphine In dichloromethane at 20℃; for 0.0166667h; | 92% |
With dinitrogen tetroxide impregnated on activated charcoal In tetrachloromethane for 10h; Heating; | 85% |
Conditions | Yield |
---|---|
With hydrogenchloride; sodium nitrite In water at 70 - 75℃; for 3h; Inert atmosphere; | 68% |
With citrate buffer; sodium nitrite In acetone at 37℃; for 4h; | |
With sodium nitrite In acetone at 37℃; for 4h; effect of varios organic solvents; | |
With sodium nitrite In water at 37℃; for 4h; inhibitory effect of organic and inorganic salts; |
Conditions | Yield |
---|---|
With trifluoroamine oxide at -10℃; for 1.5h; | A 30% B 45% |
N1,N1,N3,N3-tetraethyl-propane-1,2,3-triyltriamine
B
N-Nitrosodiethylamine
Conditions | Yield |
---|---|
With cis-nitrous acid |
diethylammonium, NO3(1-)-salt
N-Nitrosodiethylamine
Conditions | Yield |
---|---|
at 170℃; |
Conditions | Yield |
---|---|
With diethyl ether; nitrosylchloride at -20 - -15℃; |
ethanol
tetranitromethane
acetic acid
triethylamine
N-Nitrosodiethylamine
Conditions | Yield |
---|---|
at 100℃; | |
at 100℃; |
Conditions | Yield |
---|---|
With silver nitrate; acetonitrile |
Empirical Formula: C4H10N2O
Molecular Weight: 102.135 g/mol
EINECS: 200-226-1
Index of Refraction: 1.442
Density: 0.95 g/cm3
Flash Point: 59 °C
Enthalpy of Vaporization: 39.34 kJ/mol
Boiling Point: 173.9 °C at 760 mmHg
Vapour Pressure: 1.66 mmHg at 25 °C
Storage tempreture: 2-8 °C
Appearance: Clear slightly yellow liquid
Form: Liquid
Color: Yellow
Stable: Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents, reducing agents.
Structure of N-Nitrosodiethylamine (CAS NO.55-18-5):
IUPAC Name: N,N-Diethylnitrous amide
Product Categories of N-Nitrosodiethylamine (CAS NO.55-18-5): Nitrosamine
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | intraperitoneal | 175mg/kg (175mg/kg) | Carcinogenesis Vol. 5, Pg. 533, 1984. | |
guinea pig | LD50 | oral | 250mg/kg (250mg/kg) | Zeitschrift fuer Krebsforschung. Vol. 69, Pg. 103, 1967. | |
hamster | LD50 | subcutaneous | 232mg/kg (232mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BLOOD: OTHER CHANGES LIVER: OTHER CHANGES | British Journal of Cancer. Vol. 33, Pg. 411, 1976. |
hamster | LD50 | unreported | 246mg/kg (246mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LIVER: OTHER CHANGES KIDNEY, URETER, AND BLADDER: "INFLAMMATION, NECROSIS, OR SCARRING OF BLADDER" | Journal of the National Cancer Institute. Vol. 49, Pg. 595, 1972. |
mouse | LD50 | intramuscular | 356mg/kg (356mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 17(10), Pg. 51, 1973. | |
mouse | LD50 | intraperitoneal | 132mg/kg (132mg/kg) | JNCI, Journal of the National Cancer Institute. Vol. 62, Pg. 911, 1979. | |
mouse | LD50 | intravenous | 293mg/kg (293mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 17(10), Pg. 51, 1973. | |
mouse | LD50 | oral | 200mg/kg (200mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | National Technical Information Service. Vol. OTS0555387, |
mouse | LD50 | unreported | 210mg/kg (210mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(8), Pg. 11, 1980. | |
rat | LD50 | intraperitoneal | 216mg/kg (216mg/kg) | Biochemical Journal. Vol. 85, Pg. 72, 1962. | |
rat | LD50 | intravenous | 280mg/kg (280mg/kg) | IARC Scientific Publications. Vol. 4, Pg. 45, 1973. | |
rat | LD50 | oral | 220mg/kg (220mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LIVER: FATTY LIVER DEGERATION | Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 1167, 1964. |
rat | LD50 | subcutaneous | 195mg/kg (195mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE LIVER: OTHER CHANGES | Experimental Pathology Vol. 27, Pg. 171, 1985. |
rat | LD50 | unreported | 245mg/kg (245mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(8), Pg. 11, 1980. |
NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 1 ,1972,p. 107.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) , IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 ,1978,p. 83.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) , IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 28 ,1982,p. 151.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 ,1978,p. 83.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Studies (ipr); Clear Evidence: mouse, rat RRCRBU Recent Results in Cancer Research. 52 (1975),1. . Reported in EPA TSCA Inventory. Community Right-To-Know List.
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A transplacental carcinogen. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS and AMINES.
Hazard Codes of N-Nitrosodiethylamine (CAS NO.55-18-5): T,F
Risk Statements: 45-22-39/23/24/25-23/24/25-11
R11:Highly flammable.
R22:Harmful if swallowed.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R39:Danger of very serious irreversible effects.
R45:May cause cancer.
Safety Statements: 53-45-36/37-16
S16:Keep away from sources of ignition.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53:Avoid exposure - obtain special instructions before use.
DFG MAK: Animal Carcinogen, Suspected Human Carcinogen
For occupational chemical analysis use OSHA: #27 or NIOSH: Nitrosamines, 2522.
N-Nitrosodiethylamine ,its cas register number is 55-18-5. It also can be called Nitrosodiethylamine ; N-ethyl-N-nitrosoethanamine ; Ethanamine, N-ethyl-N-nitroso- ;and Diethylnitrosamine . N-Nitrosodiethylamine (CAS NO.55-18-5) reacts with strong oxidizing agents, and can be hydrolyzed by hydrogen bromide in acetic acid .