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| CAS No.: | 55-18-5 | |
|---|---|---|
| Name: | N-NITROSODIETHYLAMINE | |
| Article Data: | 97 | |
| Molecular Structure: | ||
|
|
||
| Formula: | C4H10 N2 O | |
| Molecular Weight: | 102.136 | |
| Synonyms: | Diethylamine,N-nitroso- (6CI,8CI); DEN; DEN (mutagen); DENA; Diethylnitrosamide;Diethylnitrosamine; Diethylnitrosoamine; N,N-Diethylnitrosoamine;N-Ethyl-N-nitrosoethanamine; N-Nitroso-N,N-diethylamine; N-Nitrosodiethylamine;NDEA; NSC 132; Nitrosodiethylamine | |
| EINECS: | 200-226-1 | |
| Density: | 0.95g/cm3 | |
| Melting Point: | <25℃ | |
| Boiling Point: | 173.9°Cat760mmHg | |
| Flash Point: | 59°C | |
| Solubility: |
substantial
Stability
Toxicology
|
|
| Appearance: | yellow liquid | |
| Hazard Symbols: |
 T, F
|
|
| Risk Codes: | R45; R22; R39/23/24/25; R23/24/25; R11 | |
| Safety: | Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A transplacental carcinogen. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS and AMINES. | |
Analytical Methods: | For occupational chemical analysis use OSHA: #27 or NIOSH: Nitrosamines, 2522. |
|
| PSA: | 32.67000 | |
| LogP: | 1.00960 | |
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| Conditions | Yield |
|---|---|
| With [NO(1+)*18-crown-6*H(NO3)2(1-)] In dichloromethane at 20℃; for 0.0833333h; | 100% |
| With magnesium hydrogen sulfate; silica gel; sodium nitrite In dichloromethane at 20℃; for 1h; Nitrosation; | 98% |
| With aluminium trichloride; silica gel; sodium nitrite In dichloromethane at 20℃; for 0.5h; Nitrosation; | 98% |
| Conditions | Yield |
|---|---|
| With tin(IV) chloride; sodium nitrite In tetrachloromethane for 14h; Heating; | 96% |
| With bromine; triphenylphosphine In dichloromethane at 20℃; for 0.0166667h; | 92% |
| With dinitrogen tetroxide impregnated on activated charcoal In tetrachloromethane for 10h; Heating; | 85% |
| Conditions | Yield |
|---|---|
| With hydrogenchloride; sodium nitrite In water at 70 - 75℃; for 3h; Inert atmosphere; | 68% |
| With citrate buffer; sodium nitrite In acetone at 37℃; for 4h; | |
| With sodium nitrite In acetone at 37℃; for 4h; effect of varios organic solvents; | |
| With sodium nitrite In water at 37℃; for 4h; inhibitory effect of organic and inorganic salts; |
| Conditions | Yield |
|---|---|
| With trifluoroamine oxide at -10℃; for 1.5h; | A 30% B 45% |
- 34155-23-2
N1,N1,N3,N3-tetraethyl-propane-1,2,3-triyltriamine
B
- 55-18-5
N-Nitrosodiethylamine
| Conditions | Yield |
|---|---|
| With cis-nitrous acid |
- 27096-30-6
diethylammonium, NO3(1-)-salt
- 55-18-5
N-Nitrosodiethylamine
| Conditions | Yield |
|---|---|
| at 170℃; |
| Conditions | Yield |
|---|---|
| With diethyl ether; nitrosylchloride at -20 - -15℃; |
- 64-17-5
ethanol
- 509-14-8
tetranitromethane
- 64-19-7
acetic acid
- 121-44-8
triethylamine
- 55-18-5
N-Nitrosodiethylamine
| Conditions | Yield |
|---|---|
| at 100℃; | |
| at 100℃; |
| Conditions | Yield |
|---|---|
| With silver nitrate; acetonitrile |
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Chemistry
Empirical Formula: C4H10N2O
Molecular Weight: 102.135 g/mol
EINECS: 200-226-1
Index of Refraction: 1.442
Density: 0.95 g/cm3
Flash Point: 59 °C
Enthalpy of Vaporization: 39.34 kJ/mol
Boiling Point: 173.9 °C at 760 mmHg
Vapour Pressure: 1.66 mmHg at 25 °C
Storage tempreture: 2-8 °C
Appearance: Clear slightly yellow liquid
Form: Liquid
Color: Yellow
Stable: Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents, reducing agents.
Structure of N-Nitrosodiethylamine (CAS NO.55-18-5):
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IUPAC Name: N,N-Diethylnitrous amide
Product Categories of N-Nitrosodiethylamine (CAS NO.55-18-5): Nitrosamine
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | intraperitoneal | 175mg/kg (175mg/kg) | Carcinogenesis Vol. 5, Pg. 533, 1984. | |
| guinea pig | LD50 | oral | 250mg/kg (250mg/kg) | Zeitschrift fuer Krebsforschung. Vol. 69, Pg. 103, 1967. | |
| hamster | LD50 | subcutaneous | 232mg/kg (232mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BLOOD: OTHER CHANGES LIVER: OTHER CHANGES | British Journal of Cancer. Vol. 33, Pg. 411, 1976. |
| hamster | LD50 | unreported | 246mg/kg (246mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LIVER: OTHER CHANGES KIDNEY, URETER, AND BLADDER: "INFLAMMATION, NECROSIS, OR SCARRING OF BLADDER" | Journal of the National Cancer Institute. Vol. 49, Pg. 595, 1972. |
| mouse | LD50 | intramuscular | 356mg/kg (356mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 17(10), Pg. 51, 1973. | |
| mouse | LD50 | intraperitoneal | 132mg/kg (132mg/kg) | JNCI, Journal of the National Cancer Institute. Vol. 62, Pg. 911, 1979. | |
| mouse | LD50 | intravenous | 293mg/kg (293mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 17(10), Pg. 51, 1973. | |
| mouse | LD50 | oral | 200mg/kg (200mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | National Technical Information Service. Vol. OTS0555387, |
| mouse | LD50 | unreported | 210mg/kg (210mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(8), Pg. 11, 1980. | |
| rat | LD50 | intraperitoneal | 216mg/kg (216mg/kg) | Biochemical Journal. Vol. 85, Pg. 72, 1962. | |
| rat | LD50 | intravenous | 280mg/kg (280mg/kg) | IARC Scientific Publications. Vol. 4, Pg. 45, 1973. | |
| rat | LD50 | oral | 220mg/kg (220mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LIVER: FATTY LIVER DEGERATION | Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 1167, 1964. |
| rat | LD50 | subcutaneous | 195mg/kg (195mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE LIVER: OTHER CHANGES | Experimental Pathology Vol. 27, Pg. 171, 1985. |
| rat | LD50 | unreported | 245mg/kg (245mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(8), Pg. 11, 1980. |
Consensus Reports
NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 1 ,1972,p. 107.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) , IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 ,1978,p. 83.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) , IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 28 ,1982,p. 151.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 ,1978,p. 83.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Studies (ipr); Clear Evidence: mouse, rat RRCRBU Recent Results in Cancer Research. 52 (1975),1. . Reported in EPA TSCA Inventory. Community Right-To-Know List.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A transplacental carcinogen. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS and AMINES.
Hazard Codes of N-Nitrosodiethylamine (CAS NO.55-18-5): 
T,
F
Risk Statements: 45-22-39/23/24/25-23/24/25-11
R11:Highly flammable.
R22:Harmful if swallowed.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R39:Danger of very serious irreversible effects.
R45:May cause cancer.
Safety Statements: 53-45-36/37-16
S16:Keep away from sources of ignition.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53:Avoid exposure - obtain special instructions before use.
Standards and Recommendations
DFG MAK: Animal Carcinogen, Suspected Human Carcinogen
Analytical Methods
For occupational chemical analysis use OSHA: #27 or NIOSH: Nitrosamines, 2522.
Specification
N-Nitrosodiethylamine ,its cas register number is 55-18-5. It also can be called Nitrosodiethylamine ; N-ethyl-N-nitrosoethanamine ; Ethanamine, N-ethyl-N-nitroso- ;and Diethylnitrosamine . N-Nitrosodiethylamine (CAS NO.55-18-5) reacts with strong oxidizing agents, and can be hydrolyzed by hydrogen bromide in acetic acid .