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CAS No.: | 554-12-1 |
---|---|
Name: | Methyl propionate |
Article Data: | 249 |
Molecular Structure: | |
Formula: | C4H8O2 |
Molecular Weight: | 88.1063 |
Synonyms: | Propionicacid, methyl ester (8CI);Methyl propanoate;Methylpropylate;NSC 9375; |
EINECS: | 209-060-4 |
Density: | 0.898 g/cm3 |
Melting Point: | -88 °C |
Boiling Point: | 67.9 °C at 760 mmHg |
Flash Point: | 6.1 °C |
Solubility: | 5 g/100 mL at 20 °C in water |
Appearance: | colourless liquid |
Hazard Symbols: | F, Xn |
Risk Codes: | 11-20 |
Safety: | 16-24-29-33 |
Transport Information: | UN 1248 3/PG 2 |
PSA: | 26.30000 |
LogP: | 0.56940 |
Conditions | Yield |
---|---|
With boron trifluoride at 65℃; for 0.333333h; | 100% |
With Dowex 50W×2 hydrogen form at 103 - 108℃; Reagent/catalyst; Autoclave; Large scale; | 98.6% |
With bis(acetylacetonato)dioxidomolybdenum(VI) for 8h; Heating; | 72% |
acrylic acid methyl ester
propanoic acid methyl ester
Conditions | Yield |
---|---|
With hydrogen; palladium(II) complex of ferrocenylamine sulfide (2) In acetone under 4137.2 Torr; for 0.25h; or with catalyst 3, 0.75 h; | 100% |
With [Ir(1-(1′-methylpyrazole)-3-(4′-methylphenyl)triazenide)Cp*Cl]; isopropyl alcohol at 90℃; for 6h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; Glovebox; | 99% |
With tetrahydroxydiboron; water; sodium hydrogencarbonate In tetrahydrofuran at 60℃; for 8h; Inert atmosphere; | 99% |
ethene
carbon monoxide
trans-[Pd(COEt)(OTs)(PPh3)2]
B
propanoic acid methyl ester
[Pd(COEt)(PPh3)3](TsO)
Conditions | Yield |
---|---|
at -80.16 - 49.84℃; under 3000.3 Torr; for 0.0133333h; | A 0.1% B 100% C n/a |
Conditions | Yield |
---|---|
With methanesulfonic acid; palladium diacetate; bis(phosphaadamantyl)diphosphine at 90℃; | 99% |
With α,α′-bis(2-pyridyl(tert-butyl)phosphino)-o-xylene; palladium dichloride at 80℃; under 15001.5 - 22502.3 Torr; for 20h; Reagent/catalyst; Pressure; Inert atmosphere; Autoclave; | 99% |
With bis(acetylacetonato)palladium(II); 1,1’-ferrocenediyl-bis(tert-butyl(pyridin-2-yl)phosphine); toluene-4-sulfonic acid at 80℃; for 0.166667h; Catalytic behavior; Reagent/catalyst; Temperature; Autoclave; Inert atmosphere; | 99% |
methanol
trans-[Pd(COEt)(OTs)(PPh3)2]
carbon monoxide
trans-[Pd(COOMe)(OTs)(PPh3)2]
B
propanoic acid methyl ester
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid; triphenylphosphine In methanol Pd complex, (0.1 mmol) reacted with MeOH containing PPh3 (0.1 mmol) + p-toluenesulfonic acid (0.1 mmol) satd. with CO (ca. 20 min); pptd. with cold H2O; suspn. filtered; ppt. washed with cold H2O; dried (vac.); | A 90% B 99% |
Conditions | Yield |
---|---|
With palladium diacetate; toluene-4-sulfonic acid; 1,2-bis[di(t-butyl)phosphinomethyl]benzene at 100℃; under 3750.38 Torr; for 20h; Inert atmosphere; Autoclave; regioselective reaction; | 99% |
Conditions | Yield |
---|---|
With triethylamine at 160℃; for 5h; Autoclave; Green chemistry; | 98% |
With diiron nonacarbonyl at 180℃; for 1h; Sealed tube; |
Conditions | Yield |
---|---|
With tetrahydroxydiboron; water; sodium hydrogencarbonate In methanol at 80℃; for 12h; | 98% |
methanol
1,1'-(2-oxoimidazolidine-1,3-diyl)bis(propan-1-one)
A
imidazolidone
B
propanoic acid methyl ester
Conditions | Yield |
---|---|
With C17H23BN2O at 50℃; under 760.051 Torr; for 15h; Inert atmosphere; chemoselective reaction; | A 97% B n/a |
methanol
1,1'-(2-oxoimidazolidine-1,3-diyl)bis(propan-1-one)
A
propanoic acid methyl ester
B
1-propionyl-2-oxo-imidazolidine
Conditions | Yield |
---|---|
With C17H23BN2O at 25℃; under 760.051 Torr; for 0.25h; Inert atmosphere; chemoselective reaction; | A n/a B 96% |
1. | skn-rbt 500 mg/24H MOD | FCTOD7 Food and Chemical Toxicology. 20 (Suppl)(1982),765. | ||
2. | orl-rat LD50:5 g/kg | FCTOD7 Food and Chemical Toxicology. 20 (Suppl)(1982),765. | ||
3. | orl-mus LD50:3460 mg/kg | GTPZAB Gigiena Truda i Professionalnye Zabolevaniia. Labor Hygiene and Occupational Diseases. 18 (3)(1974),48. | ||
4. | ihl-mus LC50:27 g/m3 | GTPZAB Gigiena Truda i Professionalnye Zabolevaniia. Labor Hygiene and Occupational Diseases. 18 (3)(1974),48. | ||
5. | orl-rbt LDLo:2550 mg/kg | AMIHAB AMA Archives of Industrial Health. 21 (1960),100. |