CAS No.5570-77-4,4-Chloro-N-methylpiperidine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	5570-77-4
Name:	4-Chloro-N-methylpiperidine
Article Data:	11
Cas Database

Formula:	C₆H₁₂ClN
Molecular Weight:	133.621
Synonyms:	1-Methyl-4-chloropiperidine;1-Methyl-4-piperidinyl chloride;1-Methyl-4-piperidyl chloride;4-Chloro-1-methylpiperidine;N-Methyl-4-chloropiperidine;Piperidine,4-chloro-1-methyl-;
EINECS:	226-942-4
Density:	1.04 g/cm³
Melting Point:	160-165 °C
Boiling Point:	165.7 °C at 760 mmHg
Flash Point:	54 °C
Solubility:	1.533g/L at 29℃
Hazard Symbols:	Xi
Risk Codes:	10-34-36/38
Safety:	22-24/25
PSA:	3.24000
LogP:	1.25730

Synthetic route

: 106-52-5
N-methyl-4-hydroxypiperidine

: 5570-77-4
4-chloro-1-methylpiperidine

Conditions

Conditions	Yield
With thionyl chloride; triethylamine In dichloromethane at 20 - 40℃; for 2h;	80%
With thionyl chloride; benzene
With thionyl chloride

: 931-20-4
1-methylpiperidin-2-one

: 103057-10-9
4-chloromethyl-1-tritylimidazole

: 5570-77-4
4-chloro-1-methylpiperidine

Conditions

Conditions	Yield
With n-butyllithium; ammonia; diisopropylamine In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate	52%
With n-butyllithium; ammonia; diisopropylamine In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate	52%

: 1445-73-4
1-Methyl-4-piperidone

: 5570-77-4
4-chloro-1-methylpiperidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Raney nickel / 125 °C / 102971 Torr / Hydrogenation 2: benzene; thionyl chloride View Scheme

: 25012-72-0
ethyl 1-methyl-4-oxo-piperidin-3-carboxylate

: 5570-77-4
4-chloro-1-methylpiperidine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: water; hydrochloric acid 2: Raney nickel / 125 °C / 102971 Torr / Hydrogenation 3: benzene; thionyl chloride View Scheme

: 6315-60-2
3,3'-methylimino-di-propionic acid diethyl ester

: 5570-77-4
4-chloro-1-methylpiperidine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: NaH; benzene 2: water; hydrochloric acid 3: Raney nickel / 125 °C / 102971 Torr / Hydrogenation 4: benzene; thionyl chloride View Scheme

: 5382-23-0
4-chloro-N-methyl-piperidine hydrochloride

: 5570-77-4
4-chloro-1-methylpiperidine

Conditions

Conditions	Yield
With potassium hydroxide
With ammonia
With potassium carbonate In water	14 g

: 5570-77-4
4-chloro-1-methylpiperidine

: 2222-33-5
dibenzosuberenon

: 3967-32-6
5-(1-methyl-4-piperidyl)-5H-dibenzocyclohepten-5-ol

Conditions

Conditions	Yield
Stage #1: 4-chloro-1-methylpiperidine With iodine; magnesium In tetrahydrofuran for 5h; Reflux; Inert atmosphere; Stage #2: With (trimethylsilyl)methylmagnesium chloride; lithium chloride; zinc(II) chloride In tetrahydrofuran; diethyl ether at 20℃; for 0.75h; Inert atmosphere; Stage #3: dibenzosuberenon In tetrahydrofuran; diethyl ether at 0℃; for 2h; Inert atmosphere;	99%
Stage #1: 4-chloro-1-methylpiperidine With magnesium In tetrahydrofuran at 60 - 65℃; for 1h; Inert atmosphere; Large scale; Stage #2: dibenzosuberenon In tetrahydrofuran at 5 - 20℃; for 1h; Temperature; Inert atmosphere; Large scale;

: 5570-77-4
4-chloro-1-methylpiperidine

: 91759-32-9
2-Thiobarbituric acid

: 2-<(1-Methylpiperidin-4-yl)sulfanyl>pyrimidine-4,6-diol hydrochloride

Conditions

Conditions	Yield
In acetone for 1h; Ambient temperature;	94%

: 5570-77-4
4-chloro-1-methylpiperidine

: 4-chloro-1-formylpiperidine

Conditions

Conditions	Yield
With [2,2]bipyridinyl; C10H16NO; copper(II) bis(trifluoromethanesulfonate); copper(l) chloride In acetonitrile at 20℃; for 2h;	91%

: 5570-77-4
4-chloro-1-methylpiperidine

: 957199-68-7
C15H15N3O2

: 1182125-60-5
1-[2-(dimethylamino)ethyl]-4-hydroxy-4-(1-methylpiperidin-4-yl)-1H-pyrrolo[3,2-g]isoquinolin-9(4H)-one

Conditions

Conditions	Yield
Stage #1: 4-chloro-1-methylpiperidine With magnesium In tetrahydrofuran for 1h; Inert atmosphere; Reflux; Stage #2: C15H15N3O2 In tetrahydrofuran at 0℃; Inert atmosphere; Reflux;	85%

Raw Materials

6315-60-2

931-20-4

106-52-5

Downstream Products

314-03-4

Total:167 Page 1 of 5 1 2 3 4 5 Next>>

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Chemistry

IUPAC Name: 4-Chloro-1-methylpiperidine
Canonical SMILES: CN1CCC(CC1)Cl
InChI: InChI=1S/C6H12ClN/c1-8-4-2-6(7)3-5-8/h6H,2-5H2,1H3
InChIKey: MYGXGCCFTPKWIH-UHFFFAOYSA-N
Molecular Weight: 133.61918 [g/mol]
Molecular Formula: C₆H₁₂ClN
XLogP3-AA: 1.4
H-Bond Donor: 0
H-Bond Acceptor: 1
EINECS: 226-942-4
Melting Point: 160-165 °C
Index of Refraction: 1.482
Molar Refractivity: 36.47 cm³
Molar Volume: 127.8 cm³
Surface Tension: 31.9 dyne/cm
Density: 1.04 g/cm³
Flash Point: 54 °C
Enthalpy of Vaporization: 40.22 kJ/mol
Boiling Point: 165.7 °C at 760 mmHg
Vapour Pressure: 1.85 mmHg at 25 °C
Product Categories of 4-Chloro-N-methylpiperidine (CAS NO.5570-77-4): PHARMACEUTICAL INTERMEDIATES; Heterocyclic Compounds

Uses

4-Chloro-N-methylpiperidine (CAS NO.5570-77-4) is an important Pharmaceutical intermediates, used for the antihistamine.

Safety Profile

Safety Information of 4-Chloro-N-methylpiperidine (CAS NO.5570-77-4):
Hazard Codes : Xi
Safety Statements : 22-24/25
22:Do not breathe dust
24/25:Avoid contact with skin and eyes

Specification

4-Chloro-N-methylpiperidine (CAS NO.5570-77-4), its Synonyms are 4-Chloro-N-methylpiperidine hydrochloride ; Piperidine, 4-chloro-1-methyl- ; 4-Chloro-1-methylpiperidine .