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CAS No.: | 55837-27-9 |
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Name: | Piretanide |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C17H18N2O5S |
Molecular Weight: | 362.406 |
Synonyms: | Arelix;Arlix;Diumax;Eurelix;HOE 118;Piretanide;S 73-4118;Tauliz;3-(Aminosulfonyl)-4-phenoxy-5-pyrrolidin-1-ylbenzoic acid;4-Phenoxy-3-pyrrolidin-1-yl-5-sulfamoyl-benzoic acid; |
EINECS: | 259-852-9 |
Density: | 1.415 g/cm3 |
Melting Point: | 225-227° |
Boiling Point: | 597.676 °C at 760 mmHg |
Flash Point: | 315.263 °C |
Appearance: | Pale yellow powder. |
PSA: | 118.31000 |
LogP: | 4.27080 |
The Piretanide, with the CAS registry number 55837-27-9, is also known as 4-Phenoxy-3-pyrrolidin-1-yl-5-sulfamoyl-benzoic acid. It belongs to the product categories of Amines; Aromatics; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds. Its EINECS number is 259-852-9. This chemical's molecular formula is C17H18N2O5S and molecular weight is 362.40. What's more, its systematic name is 4-Phenoxy-3-(1-pyrrolidinyl)-5-sulfamoylbenzoic acid. Its classification codes are: (1)Diuretic; (2)Diuretics; (3)Drug / Therapeutic Agent; (4)Membrane Transport Modulators; (5)Natriuretic Agents; (6)Reproductive Effect; (7)Sodium Potassium Chloride Symporter Inhibitors. This chemical has been synthesized in 1973 at Hoechst AG (Germany) as a loop diuretic compound by using a then-new method for introducing cyclic amine residues in an aromatic nucleus in the presence of other aromatically bonded functional groups.
Physical properties of Piretanide are: (1)ACD/LogP: 2.304; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.84; (4)ACD/LogD (pH 7.4): -0.63; (5)ACD/BCF (pH 5.5): 1.15; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 14.79; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 7; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 118.31 Å2; (13)Index of Refraction: 1.64; (14)Molar Refractivity: 92.273 cm3; (15)Molar Volume: 256.028 cm3; (16)Polarizability: 36.58×10-24cm3; (17)Surface Tension: 63.0 dyne/cm; (18)Density: 1.415 g/cm3; (19)Flash Point: 315.263 °C; (20)Enthalpy of Vaporization: 93.612 kJ/mol; (21)Boiling Point: 597.676 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: O=S(=O)(c2cc(C(=O)O)cc(c2Oc1ccccc1)N3CCCC3)N
(2)Std. InChI: InChI=1S/C17H18N2O5S/c18-25(22,23)15-11-12(17(20)21)10-14(19-8-4-5-9-19)16(15)24-13-6-2-1-3-7-13/h1-3,6-7,10-11H,4-5,8-9H2,(H,20,21)(H2,18,22,23)
(3)Std. InChIKey: UJEWTUDSLQGTOA-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | > 1gm/kg (1000mg/kg) | Yakkyoku. Pharmacy. Vol. 35, Pg. 2037, 1984. | |
guinea pig | LD50 | oral | 93mg/kg (93mg/kg) | Medicamentos de Actualidad. Vol. 18, Pg. 271, 1982. | |
mouse | LD50 | intraperitoneal | 700mg/kg (700mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 4254, 1980. |
mouse | LD50 | intravenous | 618mg/kg (618mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 4254, 1980. |
mouse | LD50 | oral | 2gm/kg (2000mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 4254, 1980. |
mouse | LD50 | subcutaneous | 660mg/kg (660mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 4254, 1980. |
rabbit | LD50 | intravenous | 178mg/kg (178mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 4254, 1980. | |
rabbit | LD50 | oral | 960mg/kg (960mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 4254, 1980. | |
rat | LD50 | intraperitoneal | 485mg/kg (485mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 4254, 1980. |
rat | LD50 | intravenous | 700mg/kg (700mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 4254, 1980. |
rat | LD50 | oral | 5601mg/kg (5601mg/kg) | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 11, Pg. 399, 1976. | |
rat | LD50 | subcutaneous | 1100mg/kg (1100mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 4254, 1980. |