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| CAS No.: | 568-72-9 |
|---|---|
| Name: | Tanshinone IIA |
| Article Data: | 9 |
| Molecular Structure: | |
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| Formula: | C19H18O3 |
| Molecular Weight: | 294.35 |
| Synonyms: | Phenanthro[1,2-b]furan-10,11-dione,6,7,8,9-tetrahydro-1,6,6-trimethyl-;TanshinoneIIA (7CI);1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione;Dan Shenketone;NSC 686518;NSC 686519;Tanshinone B;Tanshinone II; |
| Density: | 1.209 g/cm3 |
| Melting Point: | 205-207 °C |
| Boiling Point: | 480.7 °C at 760 mmHg |
| Flash Point: | 236.4 °C |
| Solubility: | Soluble in Alcohol and DMSO |
| Appearance: | Cherry crystal |
| Safety: | 24/25 |
| PSA: | 47.28000 |
| LogP: | 4.24790 |
- 81281-59-67-Benzylideneaminotheophylline
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 717878-06-31-(4-fluorophenyl)-4-nitro-1H-imidazole
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
- 17545-07-2, 35825-57-1
(+/-)-cryptotanshinone
- 568-72-9
tanshinone IIA
| Conditions | Yield |
|---|---|
| With 2,3-dicyano-5,6-dichloro-p-benzoquinone In benzene at 20℃; | 95% |
- 35825-57-1
Cryptotanshinone
- 568-72-9
tanshinone IIA
| Conditions | Yield |
|---|---|
| With 2,3-dicyano-5,6-dichloro-p-benzoquinone In benzene at 25℃; for 42h; | 91% |
- 568-72-9
tanshinone IIA
| Conditions | Yield |
|---|---|
| With palladium on activated charcoal; hydrogen In tetrahydrofuran | 40% |
- 568-72-9
tanshinone IIA
| Conditions | Yield |
|---|---|
| With sodium In tetrahydrofuran at 50℃; for 1h; Inert atmosphere; | 40% |
- 18238-29-4
6,6-dimethyl-1-vinylcyclohex-1-ene
- 113297-21-5
4,5-dihydro-3-methylbenzo[1,2-b]furan-4,5-dione
A
- 568-72-9
tanshinone IIA
B
- 118950-00-8
3,8,8-Trimethyl-8,9,10,11-tetrahydro-phenanthro[4,3-b]furan-4,5-dione
| Conditions | Yield |
|---|---|
| With 2,3-dicyano-5,6-dichloro-p-benzoquinone 1) neat, ultrasound, 45 deg C, 2h, (or benzene, 12h, reflux), 2) benzene, 12h, reflux; Yield given. Multistep reaction. Yields of byproduct given; | |
| Yield given. Multistep reaction. Yields of byproduct given; | |
| With 2,3-dicyano-5,6-dichloro-p-benzoquinone 1) benzene, reflux, 12h, (or ultrasonification, 45 deg C, 2h), 2) benzene, 12h, reflux; Yield given. Multistep reaction. Yields of byproduct given; |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 10 steps 1: 1.) n-BuLi, TMEDA / 1.) hexane, 45 deg C, 30 min, 2.) THF, 55-60 deg C, 20 h 2: 97 percent / AlCl3 / CH2Cl2 / 0.25 h / 0 °C 3: 95 percent / BBr3 / CH2Cl2 / 4 h / -78 - 25 °C 4: 87 percent / DMAP / pyridine / 1.) 0 deg C -> 25 deg C, 1 h, 2.) 25 deg C, 48 h 5: 71 percent / LiCl, 4A sieves, Me4Sn, 2,6-di-tert-butylhydroxytoluene / PdCl2(dppf) / dimethylformamide / 12 h / 90 °C / 2585.7 Torr 6: 1.) LiHMDS, 2,2,2-trifluoroethyl trifluoroacetate, 2.) MsN3, Et3N / 1.) THF, -78 deg C, 45 min, 2.) MeCN, H2O, 25 deg C, 6 h 7: 64 percent / benzene / 24 h / Ambient temperature; Irradiation 8: 84 percent / n-Bu4NF, O2 / tetrahydrofuran / 40 h / 25 °C 9: 100 percent / conc. H2SO4 / ethanol / 0.75 h / 25 °C 10: 91 percent / DDQ / benzene / 42 h / 25 °C View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 10 steps 1: 93 percent / PdCl2(dppf) / tetrahydrofuran / 15 h / Heating 2: 97 percent / AlCl3 / CH2Cl2 / 0.25 h / 0 °C 3: 95 percent / BBr3 / CH2Cl2 / 4 h / -78 - 25 °C 4: 87 percent / DMAP / pyridine / 1.) 0 deg C -> 25 deg C, 1 h, 2.) 25 deg C, 48 h 5: 71 percent / LiCl, 4A sieves, Me4Sn, 2,6-di-tert-butylhydroxytoluene / PdCl2(dppf) / dimethylformamide / 12 h / 90 °C / 2585.7 Torr 6: 1.) LiHMDS, 2,2,2-trifluoroethyl trifluoroacetate, 2.) MsN3, Et3N / 1.) THF, -78 deg C, 45 min, 2.) MeCN, H2O, 25 deg C, 6 h 7: 64 percent / benzene / 24 h / Ambient temperature; Irradiation 8: 84 percent / n-Bu4NF, O2 / tetrahydrofuran / 40 h / 25 °C 9: 100 percent / conc. H2SO4 / ethanol / 0.75 h / 25 °C 10: 91 percent / DDQ / benzene / 42 h / 25 °C View Scheme |
- 171979-69-4
5,5-dimethyl-5,6,7,8-tetrahydronaphthalen-1-ol
- 568-72-9
tanshinone IIA
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1: 87 percent / DMAP / pyridine / 1.) 0 deg C -> 25 deg C, 1 h, 2.) 25 deg C, 48 h 2: 71 percent / LiCl, 4A sieves, Me4Sn, 2,6-di-tert-butylhydroxytoluene / PdCl2(dppf) / dimethylformamide / 12 h / 90 °C / 2585.7 Torr 3: 1.) LiHMDS, 2,2,2-trifluoroethyl trifluoroacetate, 2.) MsN3, Et3N / 1.) THF, -78 deg C, 45 min, 2.) MeCN, H2O, 25 deg C, 6 h 4: 64 percent / benzene / 24 h / Ambient temperature; Irradiation 5: 84 percent / n-Bu4NF, O2 / tetrahydrofuran / 40 h / 25 °C 6: 100 percent / conc. H2SO4 / ethanol / 0.75 h / 25 °C 7: 91 percent / DDQ / benzene / 42 h / 25 °C View Scheme |
- 33214-70-9
1,1-dimethyl-5-methoxytetralin
- 568-72-9
tanshinone IIA
| Conditions | Yield |
|---|---|
| Multi-step reaction with 8 steps 1: 95 percent / BBr3 / CH2Cl2 / 4 h / -78 - 25 °C 2: 87 percent / DMAP / pyridine / 1.) 0 deg C -> 25 deg C, 1 h, 2.) 25 deg C, 48 h 3: 71 percent / LiCl, 4A sieves, Me4Sn, 2,6-di-tert-butylhydroxytoluene / PdCl2(dppf) / dimethylformamide / 12 h / 90 °C / 2585.7 Torr 4: 1.) LiHMDS, 2,2,2-trifluoroethyl trifluoroacetate, 2.) MsN3, Et3N / 1.) THF, -78 deg C, 45 min, 2.) MeCN, H2O, 25 deg C, 6 h 5: 64 percent / benzene / 24 h / Ambient temperature; Irradiation 6: 84 percent / n-Bu4NF, O2 / tetrahydrofuran / 40 h / 25 °C 7: 100 percent / conc. H2SO4 / ethanol / 0.75 h / 25 °C 8: 91 percent / DDQ / benzene / 42 h / 25 °C View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 10 steps 1: 1.) n-BuLi, TMEDA / 1.) hexane, 45 deg C, 30 min, 2.) THF, 55-60 deg C, 20 h 2: 97 percent / AlCl3 / CH2Cl2 / 0.25 h / 0 °C 3: 95 percent / BBr3 / CH2Cl2 / 4 h / -78 - 25 °C 4: 87 percent / DMAP / pyridine / 1.) 0 deg C -> 25 deg C, 1 h, 2.) 25 deg C, 48 h 5: 71 percent / LiCl, 4A sieves, Me4Sn, 2,6-di-tert-butylhydroxytoluene / PdCl2(dppf) / dimethylformamide / 12 h / 90 °C / 2585.7 Torr 6: 1.) LiHMDS, 2,2,2-trifluoroethyl trifluoroacetate, 2.) MsN3, Et3N / 1.) THF, -78 deg C, 45 min, 2.) MeCN, H2O, 25 deg C, 6 h 7: 64 percent / benzene / 24 h / Ambient temperature; Irradiation 8: 84 percent / n-Bu4NF, O2 / tetrahydrofuran / 40 h / 25 °C 9: 100 percent / conc. H2SO4 / ethanol / 0.75 h / 25 °C 10: 91 percent / DDQ / benzene / 42 h / 25 °C View Scheme |
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Chemistry
Molecular Formula: C14H10O3
Molar mass: 226.23 g/mol
Density: 1.209 g/cm3
Flash Point: 236.4 °C
Index of Refraction: 1.587
Boiling Point: 480.7 °C at 760 mmHg
Vapour Pressure: 2.12E-09 mmHg at 25 °C
Product categories of Tanshinone IIA (CAS NO.568-72-9): Plant Oils, Toxins, Phenolic Acids & Derivatives;Danshen
Structure of Tanshinone IIA (CAS NO.568-72-9):
XLogP3-AA: 4.3
H-Bond Donor: 0
H-Bond Acceptor: 3
IUPAC Name of Tanshinone IIA (CAS NO.568-72-9): 1,6,6-Trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione
Canonical SMILES: CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C
InChI: InChI=1S/C19H18O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,
2)3)15(12)17(21)16(20)14(10)18/h6-7,9H,4-5,8H2,1-3H3
InChIKey: HYXITZLLTYIPOF-UHFFFAOYSA-N
Specification
Tanshinone IIA , its cas register number is 568-72-9. It also can be called Phenanthro[1,2-b]furan-10,11-dione, 6,7,8,9-tetrahydro-1,6,6-trimethyl- and 1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione .