Name: Chlorotetracycline
SKU: 57-62-5

Products Categories

Pharmaceutical (113)
Others (19)
Organic Chemicals (12)
Agrochemicals (5)
Materials (5)
Reagent (2)
Plant Extract (2)
Food Additives (1)

Basic Information

Molecular Structure:
CAS No.:	57-62-5
Name:	Chlorotetracycline

Formula:	C₂₂H₂₃ClN₂O₈
Molecular Weight:	478.886
Synonyms:	2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-(7CI,8CI);2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,[4S-(4a,4aa,5aa,6b,12aa)]-;Aureomicina;Aureomycin;Aureomykoin;Aurofac;Aureocina;A-Mycin;Acronize;7-Chlorotetracycline;7-Chlortetracycline;Tri-chlortetracycline;Acronize PD;Chrysomykine;Chlortetracycline;Centraureo;Chlorocyclinum;
EINECS:	200-341-7
Density:	1.7 g/cm³
Melting Point:	168.5oC
Boiling Point:	821.078 °C at 760 mmHg
Flash Point:	450.372 °C
Solubility:	0.63g/L(25 oC)
Appearance:	Golden yellow crystal powder
Hazard Symbols:	Xn
Risk Codes:	22
PSA:	181.62000
LogP:	1.13930

Synthetic route

: 67-56-1
methanol

: 14297-93-9
4-epi chlortetracycline

NaH2PO4: NaH2PO4

: 57-62-5
Chlortetracycline

Conditions

Conditions	Yield
Gleichgeweicht;

...Expand

: 57-62-5
Chlortetracycline

A: C20H16ClNO9

B: 4-(((1S,4R,10S)-9-chloro-6-hydroxy-1-methyl-3,5-dioxo-1,3,4,5-tetrahydro-1,4-methanobenzo[c]oxepin-10-yl)methyl)-2,3,5,6-tetrahydroxybenzamide

Conditions

Conditions	Yield
With mercury(II) diacetate; magnesium sulfate; acetic acid; sodium hydroxide In tetrahydrofuran at 50℃; for 48h;	A 17.5% B 34%

: 57-62-5
Chlortetracycline

: 514-53-4
isochlortetracycline

Conditions

Conditions	Yield
With sodium hydroxide
With potassium hydroxide

: 57-62-5
Chlortetracycline

: 3811-34-5, 66749-14-2, 66749-15-3
(S)-4-((1S)-4-carbamoyl-2t-dimethylamino-3,6ξ-dihydroxy-5-oxo-cyclohex3-en-r-yl)-3-((S)-7-chloro-4-hydroxy-1-methyl-3-oxo-phthalan-1-yl)-butyric acid

Conditions

Conditions	Yield
With sodium hydroxide; sodium dithionite β-aureomycinic acid;
With sodium hydroxide; sodium dithionite α-aureomycinic acid;
With sodium hydroxide; zinc β-aureomycinic acid;

: 57-62-5
Chlortetracycline

: 1885-13-8
4-methoxyphthalic acid

Conditions

Conditions	Yield
Behandeln des Reaktionsprodukts mit KMnO4;

: 57-62-5
Chlortetracycline

: 60-54-8
TETRACYCLINE

Conditions

Conditions	Yield
With palladium on activated charcoal; 2-methoxy-ethanol; triethylamine Hydrogenation;
With 1,4-dioxane; methanol; palladium on activated charcoal Hydrogenation;

: 57-62-5
Chlortetracycline

: 1665-56-1, 7518-17-4
anhydrotetracycline

Conditions

Conditions	Yield
With hydrogen iodide

: 57-62-5
Chlortetracycline

: 4497-08-9
(4S,4aS,12aS)-7-chloro-4-(dimethylamino)-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydrotetracene-2-carboxamide

Conditions

Conditions	Yield
With hydrogenchloride

: 57-62-5
Chlortetracycline

: 14297-93-9
4-epi chlortetracycline

Conditions

Conditions	Yield
With sodium dihydrogenphosphate; N,N-dimethyl-formamide

: 57-62-5
Chlortetracycline

: 3811-33-4, 66749-13-1
(S)-4-(4-carbamoyl-2,3,5-trihydroxy-phenyl)-3-((S)-7-chloro-4-hydroxy-1-methyl-3-oxo-phthalan-1-yl)-butyric acid

Conditions

Conditions	Yield
With sodium hydroxide

Raw Materials

14297-93-9

67-56-1

Downstream Products

60-54-8

1885-13-8

514-53-4

Total:117 Page 1 of 4 1 2 3 4 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 57-62-5

Specification

The Chlortetracycline, with the CAS registry number 57-62-5, is also known as 7-Chlorotetracycline. It belongs to the product categories of Pharmaceuticals. Its EINECS registry number is 200-341-7. This chemical's molecular formula is C₂₂H₂₃ClN₂O₈ and molecular weight is 478.88. Its IUPAC name is called (4S,4αS,5αS,6S,12αS,Z)-2-[amino(hydroxy)methylene]-7-chloro-4-(dimethylamino)-6,10,11,12α-tetrahydroxy-6-methyl-4α,5,5α,6-tetrahydrotetracene-1,3,12(2H,4H,12αH)-trione. This chemical's classification codes are Agricultural Chemical; Anti-Bacterial Agents; Anti-Infective Agents; Antibacterial; Antiparasitic Agents; Antiprotozoal; Antiprotozoal agents; Drug / Therapeutic Agent; Enzyme Inhibitors; Fungicide, bactericide, wood preservative; Protein Synthesis Inhibitors; Reproductive Effect. When you are using this chemical, please be cautious about it. This chemical may cause damage to health. It is harmful if swallowed.

Physical properties of Chlortetracycline: (1)ACD/LogP: 1.32; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): -3; (4)ACD/LogD (pH 7.4): -4; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 10; (10)#H bond donors: 7; (11)#Freely Rotating Bonds: 7; (12)Index of Refraction: 1.745; (13)Molar Refractivity: 113.915 cm³; (14)Molar Volume: 281.089 cm³; (15)Surface Tension: 101.962 dyne/cm; (16)Density: 1.704 g/cm³; (17)Flash Point: 450.372 °C; (18)Enthalpy of Vaporization: 125.108 kJ/mol; (19)Boiling Point: 821.078 °C at 760 mmHg; (20)Vapour Pressure: 0 mmHg at 25°C.

Preparation: this chemical can be prepared by Streptomyces (Streptomyces aureofacieus). This reaction will need solvent ethanol.

Chlortetracycline (trade name Aureomycin, Lederle) is a tetracycline antibiotic, and was the first tetracycline to be discovered. In veterinary medicine, it is commonly used to treat conjunctivitis in cats. What's more, this chemical can be used to inhibit gram-positive and electronegative bacterium, can treat typhoid, white scour and other diseases. It also can be used as promoting growth agent.

You can still convert the following datas into molecular structure:
(1)SMILES: CN(C)[C@@H]2C(\O)=C(\C(N)=O)C(=O)[C@@]3(O)C(/O)=C4/C(=O)c1c(O)ccc(Cl)c1[C@@](C)(O)[C@H]4C[C@@H]23
(2)InChI: InChI=1/C22H23ClN2O8/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31)/t7-,8-,15-,21-,22-/m0/s1
(3)InChIKey: CYDMQBQPVICBEU-XRNKAMNCBT

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	150mg/kg (150mg/kg)		"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 52, 1959.
dog	LD50	oral	750mg/kg (750mg/kg)		Antimicrobial Agents Annual. Vol. -, Pg. 595, 1960.
guinea pig	LDLo	intraperitoneal	1800mg/kg (1800mg/kg)		Antibiotiki. Vol. 20, Pg. 793, 1975.
mouse	LD50	intracrebral	48mg/kg (48mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: EXCITEMENT MUSCULOSKELETAL: CHANGES IN TEETH AND SUPPORTING STRUCTURES	Chemotherapy Vol. 26, Pg. 196, 1980.
mouse	LD50	intravenous	134mg/kg (134mg/kg)		Antibiotics and Chemotherapy Vol. 6, Pg. 623, 1956.
mouse	LD50	oral	1500mg/kg (1500mg/kg)		Antimicrobial Agents Annual. Vol. -, Pg. 595, 1960.
mouse	LDLo	intraperitoneal	192mg/kg (192mg/kg)		Compilation of LD50 Values of New Drugs.
mouse	LDLo	subcutaneous	3gm/kg (3000mg/kg)		Antibiotics and Chemotherapy Vol. 6, Pg. 623, 1956.
rat	LD50	intravenous	118mg/kg (118mg/kg)		Antibiotics and Chemotherapy Vol. 6, Pg. 623, 1956.
rat	LDLo	intraperitoneal	335mg/kg (335mg/kg)		Compilation of LD50 Values of New Drugs.
rat	LDLo	oral	3gm/kg (3000mg/kg)		Journal of Agricultural and Food Chemistry. Vol. 17, Pg. 497, 1969.

57-62-5

Refine

Country

Business Type

Certificate

Display

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

57-62-5

Specification