Products Categories
CAS No.: | 57470-78-7 |
---|---|
Name: | Celiprolol hydrochloride |
Article Data: | 2 |
Molecular Structure: | |
Formula: | C20H33N3O4.HCl |
Molecular Weight: | 415.961 |
Synonyms: | Urea,N'-[3-acetyl-4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-N,N-diethyl-,monohydrochloride (9CI);Celectol;Corliprol;NSC324509;REV 5320A;ST 1396;Selecor;Tenoloc; |
EINECS: | 260-752-2 |
Density: | 1.114g/cm3 |
Melting Point: | 197-200 °C (dec.) |
Boiling Point: | 586.5 °C at 760 mmHg |
Flash Point: | 308.5 °C |
Solubility: | Soluble in ethanol, methanol and water |
Appearance: | White crystalline solid |
PSA: | 90.90000 |
LogP: | 4.15660 |
celiprolol
(+/-)-celiprolol hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In acetone pH=5.5 - 6; | 81.3% |
With hydrogenchloride In acetone at 20℃; for 1.5h; pH=5.5 - 6; | 80% |
4-(3,3-diethylureido)phenyl acetate
(+/-)-celiprolol hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: aluminum (III) chloride; sodium chloride / 3 h / 140 °C 2: sodium hydroxide / dimethyl sulfoxide / 12 h / 50 °C 3: ethanol / 8 h / Reflux 4: hydrogenchloride / acetone / pH 5.5 - 6 View Scheme |
3-(3-Acetyl-4-hydroxy-phenyl)-1,1-diethylharnstoff
(+/-)-celiprolol hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / dimethyl sulfoxide / 12 h / 50 °C 2: ethanol / 8 h / Reflux 3: hydrogenchloride / acetone / pH 5.5 - 6 View Scheme |
4-chlorobenzonitrile
(+/-)-celiprolol hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: sodium hydroxide / water / 10 h / 140 °C / 2250.23 Torr / Autoclave 1.2: 0.5 h / 80 °C 2.1: 5% Pd/C; hydrogen / ethyl acetate / 6.5 h / 65 °C / 3750.38 Torr 3.1: sodium hydrogencarbonate / acetone / 30 °C / Reflux 4.1: aluminum (III) chloride; sodium chloride / 3 h / 140 °C 5.1: sodium hydroxide / dimethyl sulfoxide / 12 h / 50 °C 6.1: ethanol / 8 h / Reflux 7.1: hydrogenchloride / acetone / pH 5.5 - 6 View Scheme |
4-nitrophenol acetate
(+/-)-celiprolol hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: aluminum (III) chloride / nitrobenzene / 6.5 h / 20 - 140 °C 2: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / 10 h / 75 °C 3: water / 12 h / 20 °C 4: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 1034.32 Torr 5: triethylamine / tetrahydrofuran / 48 h / 40 °C 6: hydrogenchloride / acetone / 1.5 h / 20 °C / pH 5.5 - 6 View Scheme | |
Multi-step reaction with 6 steps 1: 5% Pd/C; hydrogen / ethyl acetate / 6.5 h / 65 °C / 3750.38 Torr 2: sodium hydrogencarbonate / acetone / 30 °C / Reflux 3: aluminum (III) chloride; sodium chloride / 3 h / 140 °C 4: sodium hydroxide / dimethyl sulfoxide / 12 h / 50 °C 5: ethanol / 8 h / Reflux 6: hydrogenchloride / acetone / pH 5.5 - 6 View Scheme |
p-aminophenyl acetate
(+/-)-celiprolol hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sodium hydrogencarbonate / acetone / 30 °C / Reflux 2: aluminum (III) chloride; sodium chloride / 3 h / 140 °C 3: sodium hydroxide / dimethyl sulfoxide / 12 h / 50 °C 4: ethanol / 8 h / Reflux 5: hydrogenchloride / acetone / pH 5.5 - 6 View Scheme |
4-nitro-phenol
(+/-)-celiprolol hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: sodium hydroxide / water / 0.17 h / 90 - 95 °C 2: aluminum (III) chloride / nitrobenzene / 6.5 h / 20 - 140 °C 3: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / 10 h / 75 °C 4: water / 12 h / 20 °C 5: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 1034.32 Torr 6: triethylamine / tetrahydrofuran / 48 h / 40 °C 7: hydrogenchloride / acetone / 1.5 h / 20 °C / pH 5.5 - 6 View Scheme |
1-(2-hydroxy-5-nitrophenyl)ethanone
(+/-)-celiprolol hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / 10 h / 75 °C 2: water / 12 h / 20 °C 3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 1034.32 Torr 4: triethylamine / tetrahydrofuran / 48 h / 40 °C 5: hydrogenchloride / acetone / 1.5 h / 20 °C / pH 5.5 - 6 View Scheme |
1-[5-nitro-2-(oxiran-2-ylmethoxy)phenyl]ethan-1-one
(+/-)-celiprolol hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: water / 12 h / 20 °C 2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 1034.32 Torr 3: triethylamine / tetrahydrofuran / 48 h / 40 °C 4: hydrogenchloride / acetone / 1.5 h / 20 °C / pH 5.5 - 6 View Scheme |
(+/-)-celiprolol hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 1034.32 Torr 2: triethylamine / tetrahydrofuran / 48 h / 40 °C 3: hydrogenchloride / acetone / 1.5 h / 20 °C / pH 5.5 - 6 View Scheme |
What can I do for you?
Get Best Price
IUPAC Name: 3-[3-Acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea hydrochloride
Empirical Formula: C20H34ClN3O4
Molecular Weight: 415.9547
Classification Code :Anti-adrenergic ; Drug / Therapeutic Agent ; Human Data
Einecs: 260-752-2
Freely Rotating Bonds: 11
Polar Surface Area: 62.32 Å2
Flash Point: 308.5 °C
Enthalpy of Vaporization: 92.13 kJ/mol
Boiling Point: 586.5 °C at 760 mmHg
Vapour Pressure: 1.34E-14 mmHg at 25°C
The Cas Register Number of Celiprolol hydrochloride is 57470-78-7.The chemical synonyms of Celiprolol hydrochloride (CAS NO.57470-78-7) are 3-(3-Acetyl-4-(3-((tert-butyl)amino)-2-hydroxypropoxy)phenyl)-1,1-diethyluronium chloride ; Celiprolol hydrochloride ; Urea, 3-(3-acetyl-4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)-1,1-diethyl-, monohydrochloride ; Urea, N'-(3-acetyl-4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)-N,N-diethyl-, monohydrochloride .The molecular structure of Celiprolol hydrochloride (CAS NO.57470-78-7) is
.
Celiprolol hydrochloride (CAS NO.57470-78-7) is used as antihypertensive drugs.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | intravenous | 100mg/kg (100mg/kg) | BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: NAUSEA OR VOMITING | Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 41, 1983. |
dog | LDLo | oral | 512mg/kg (512mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Oyo Yakuri. Pharmacometrics. Vol. 38, Pg. 443, 1989. |
man | TDLo | oral | 40mg/kg/2W-I (40mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Annals of Pharmacotherpy. Vol. 26, Pg. 842, 1992. |
mouse | LD50 | intravenous | 42300ug/kg (42.3mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Oyo Yakuri. Pharmacometrics. Vol. 38, Pg. 443, 1989. |
mouse | LD50 | oral | 1362mg/kg (1362mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Oyo Yakuri. Pharmacometrics. Vol. 38, Pg. 443, 1989. |
mouse | LD50 | subcutaneous | 310mg/kg (310mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Oyo Yakuri. Pharmacometrics. Vol. 38, Pg. 443, 1989. |
rat | LD50 | intravenous | 68300ug/kg (68.3mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 41, 1983. |
rat | LD50 | oral | 2157mg/kg (2157mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Oyo Yakuri. Pharmacometrics. Vol. 38, Pg. 443, 1989. |
rat | LD50 | subcutaneous | 754mg/kg (754mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Oyo Yakuri. Pharmacometrics. Vol. 38, Pg. 443, 1989. |