CAS No.58-00-4,apomorphine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	58-00-4
Name:	apomorphine
Article Data:	30

Formula:	C17H17 N O2
Molecular Weight:	267.327
Synonyms:	4H-Dibenzo[de,g]quinoline-10,11-diol,5,6,6a,7-tetrahydro-6-methyl-, (R)-; 6ab-Aporphine-10,11-diol (8CI);(-)-10,11-Dihydroxyaporphine; (-)-Apomorphine; (R)-(-)-Apomorphine; Apokyn;Apomorphin; Apomorphine; Ixense; l-Apomorphine
EINECS:	200-360-0, 206-243-0
Density:	1.299 g/cm³
Melting Point:	195°C (rough estimate)
Boiling Point:	473.4 °C at 760 mmHg
Flash Point:	268.8 °C
Solubility:
Appearance:	white to grayish powder
Hazard Symbols:	UN NO.
Transport Information:	OTH
PSA:	43.70000
LogP:	2.78780

Raw Materials

7647-01-0

124-41-4

466-95-5

57-27-2

7664-38-2

7664-93-9

60048-95-5

641-36-1

Downstream Products

314-19-2

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Chemistry

Product Name: Apomorphine (CAS NO.58-00-4)

Molecular Formula: C₁₇H₁₇NO₂
Molecular Weight: 267.3224 g/mol
Mol File: 58-00-4.mol
Einecs: 200-360-0
Appearance: White to grayish powder
Boiling point: 473.4 °C at 760 mmHg
Flash Point: 268.8 °C
Density: 1.299 g/cm³
Surface Tension: 58.2 dyne/cm
Enthalpy of Vaporization: 76.47 kJ/mol
Vapour Pressure: 1.38E-09 mmHg at 25°C
XLogP3: 2.3
H-Bond Donor: 2
H-Bond Acceptor: 3

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	rectal	50mg/kg (50mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
dog	LDLo	subcutaneous	50mg/kg (50mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
frog	LDLo	subcutaneous	300mg/kg (300mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
mouse	LD50	intraperitoneal	160mg/kg (160mg/kg)		Journal of Medicinal Chemistry. Vol. 15, Pg. 348, 1972.
mouse	LD50	intravenous	56mg/kg (56mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03170,
mouse	LD50	oral	> 100mg/kg (100mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS	Farmaco, Edizione Scientifica. Vol. 35, Pg. 951, 1980.
mouse	LDLo	subcutaneous	13mg/kg (13mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
pigeon	LDLo	subcutaneous	200mg/kg (200mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rabbit	LDLo	intravenous	10mg/kg (10mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rabbit	LDLo	subcutaneous	5mg/kg (5mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rat	LDLo	intravenous	40mg/kg (40mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 1003, 1960.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Central nervous system effects. A powerful emetic. A weak sensitizer and may cause contact dermatitis. When heated to decomposition it emits highly toxic fumes of NO_x.

Specification

Apomorphine ,its CAS NO. is 58-00-4,the synonyms is Apomorphine, nasal, britannia,4h-dibenzo[de-g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl, (r)- ; (6ar)-6-Methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-10,11-diol or apomorphine ; (6as)-5,6,6aα,7-Tetrahydro-6-methyl-4h-dibenzo[de,g]quinoline-10,11-diol ; (6ar)-5,6,6a,7-Tetrahydro-6-methyl-4h-dibenzo[de,g]quinoline-10,11-diol ; 6aβ-Aporphine-10,11-diol ; Apomorphin .