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| CAS No.: | 58-38-8 |
|---|---|
| Name: | Prochlorperazine |
| Article Data: | 6 |
| Molecular Structure: | |
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| Formula: | C20H24 Cl N3 S |
| Molecular Weight: | 373.95 |
| Synonyms: | Phenothiazine,2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]- (7CI,8CI); 2-Chloro-10-(3-[1-methyl-4-piperazinyl]propyl)phenothiazine;2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine;3-Chloro-10-[3-(1-methyl-4-piperazinyl)propyl]phenothiazine; 6140RP; Bayer A173; Capazine; Chlormeprazine; Chlorperazine; Emelent; Kronocin; Meterazin;Meterazine; N-[g-(4'-Methylpiperazinyl-1')propyl]-3-chlorophenothiazine;NSC 17478; NSC 665801; Nipodal; Proazine; Prochlorpemazine; Prochlorperazin;Prochlorperazine; Prochlorpromazine; RP 6140; SKF 4657; Temetid |
| EINECS: | 200-379-4 |
| Density: | 1.217g/cm3 |
| Melting Point: | 228 °C |
| Boiling Point: | 524.8°Cat760mmHg |
| Flash Point: | 271.2°C |
| Solubility: | 14.96mg/L(24 oC) |
| Appearance: | Clear, pale yellow, viscous liquid. |
| Safety: | Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: headache, blood pressure elevation. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl−. |
| PSA: | 35.02000 |
| LogP: | 4.52100 |
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Chemistry
IUPAC Name: 2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
Synonyms: 10H-Phenothiazine, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]- ; 2-Chloro-10-(3-(1-methyl-4-piperazinyl)-propyl)-phenothiazine ; 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-10h-phenothiazin ; 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-phenothiazin ; 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine ; 2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine ; 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine ; 3-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine
Molecular Structure of Prochlorpromazine (CAS NO.58-38-8) : 
Molecular Formula of Prochlorpromazine (CAS NO.58-38-8) : C20H24ClN3S
Molecular Weight of Prochlorpromazine (CAS NO.58-38-8) : 373.94
CAS NO: 58-38-8
EINECS : 200-379-4
Index of Refraction: 1.621
Surface Tension: 46.8 dyne/cm
Density: 1.217 g/cm3
Flash Point: 271.2 °C
Melting point 228 ºC
Enthalpy of Vaporization: 79.88 kJ/mol
Boiling Point: 524.8 °C at 760 mmHg
Vapour Pressure: 4.15E-11 mmHg at 25°C
Uses
Prochlorpromazine (CAS NO.58-38-8) is used as the phenothiazine piperazine derivatives, it's antiemetic is stronger ,but sedation is weaker.It is drugs for the treatment of mental disorders, schizophrenia and other mental disorders. Prochlorpromazine (CAS NO.58-38-8) is applicable to organic psychosis, age-related mental disorders and children's aggressive behavior disorder. Vomiting, and vomiting caused by various reasons, or refractory hiccup.
Toxicity Data With Reference
| 1. | orl-hmn TDLo:560 µg/kg/10H-I:CNS,CVS | NEJMAG New England Journal of Medicine. 312 (1985),1125. | ||
| 2. | orl-rat LD50:1800 mg/kg | 27ZIAQ Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1973,213. | ||
| 3. | ivn-rat LDLo:20 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 120 (1959),450. | ||
| 4. | orl-mus LD50:400 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),722. | ||
| 5. | ipr-mus LD50:120 mg/kg | CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. 152 (1958),1371. | ||
| 6. | scu-mus LD50:400 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),722. | ||
| 7. | orl-dog LDLo:102 mg/kg | 27ZIAQ Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1973,213. | ||
| 8. | ivn-dog LDLo:100 mg/kg | 27ZIAQ Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1973,213. | ||
| 9. | ivn-rbt LDLo:5 mg/kg |
Safety Profile
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: headache, blood pressure elevation. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl−.