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58-38-8

Basic Information
CAS No.: 58-38-8
Name: 10H-Phenothiazine,2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-
Article Data: 6
Cas Database
Molecular Structure:
Molecular Structure of 58-38-8 (10H-Phenothiazine,2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-)
Formula: C20H24 Cl N3 S
Molecular Weight: 373.95
Synonyms: Phenothiazine,2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]- (7CI,8CI); 2-Chloro-10-(3-[1-methyl-4-piperazinyl]propyl)phenothiazine;2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine;3-Chloro-10-[3-(1-methyl-4-piperazinyl)propyl]phenothiazine; 6140RP; Bayer A173; Capazine; Chlormeprazine; Chlorperazine; Emelent; Kronocin; Meterazin;Meterazine; N-[g-(4'-Methylpiperazinyl-1')propyl]-3-chlorophenothiazine;NSC 17478; NSC 665801; Nipodal; Proazine; Prochlorpemazine; Prochlorperazin;Prochlorperazine; Prochlorpromazine; RP 6140; SKF 4657; Temetid
EINECS: 200-379-4
Density: 1.217g/cm3
Melting Point: 228 °C
Boiling Point: 524.8°Cat760mmHg
Flash Point: 271.2°C
Solubility: 14.96mg/L(24 oC)
Appearance: Clear, pale yellow, viscous liquid.
Hazard Symbols: N/A
Risk Codes: N/A
Safety: Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: headache, blood pressure elevation. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl.
Transport Information: N/A
PSA: 35.02000
LogP: 4.52100
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    Molecular Formula C20H24ClN3S Molecular Weight 373.94 CAS Registry Number 58-38-8 EINECS 200-379-4Appearance:white crystalline powder, odorless, little bitter taste Storage:Store in cool and dry places, keep away from light Package:25kg/fiber drum

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Chemistry

IUPAC Name: 2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
Synonyms: 10H-Phenothiazine, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]- ; 2-Chloro-10-(3-(1-methyl-4-piperazinyl)-propyl)-phenothiazine ; 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-10h-phenothiazin ; 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-phenothiazin ; 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine ; 2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine ; 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine ; 3-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine
Molecular Structure of Prochlorpromazine (CAS NO.58-38-8) :
Molecular Formula of Prochlorpromazine (CAS NO.58-38-8) : C20H24ClN3S
Molecular Weight of Prochlorpromazine (CAS NO.58-38-8) : 373.94
CAS NO: 58-38-8
EINECS : 200-379-4
Index of Refraction: 1.621
Surface Tension: 46.8 dyne/cm
Density: 1.217 g/cm3
Flash Point: 271.2 °C
Melting point 228 ºC
Enthalpy of Vaporization: 79.88 kJ/mol
Boiling Point: 524.8 °C at 760 mmHg
Vapour Pressure: 4.15E-11 mmHg at 25°C

Uses

 Prochlorpromazine (CAS NO.58-38-8) is used as the phenothiazine piperazine derivatives, it's antiemetic is stronger ,but sedation is weaker.It is drugs for the treatment of mental disorders, schizophrenia and other mental disorders. Prochlorpromazine (CAS NO.58-38-8) is applicable to organic psychosis, age-related mental disorders and children's aggressive behavior disorder. Vomiting, and vomiting caused by various reasons, or refractory hiccup.

Toxicity Data With Reference

1.    

orl-hmn TDLo:560 µg/kg/10H-I:CNS,CVS

    NEJMAG    New England Journal of Medicine. 312 (1985),1125.
2.    

orl-rat LD50:1800 mg/kg

    27ZIAQ    Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1973,213.
3.    

ivn-rat LDLo:20 mg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 120 (1959),450.
4.    

orl-mus LD50:400 mg/kg

    NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),722.
5.    

ipr-mus LD50:120 mg/kg

    CRSBAW    Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. 152 (1958),1371.
6.    

scu-mus LD50:400 mg/kg

    NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),722.
7.    

orl-dog LDLo:102 mg/kg

    27ZIAQ    Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1973,213.
8.    

ivn-dog LDLo:100 mg/kg

    27ZIAQ    Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1973,213.
9.    

ivn-rbt LDLo:5 mg/kg

   

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: headache, blood pressure elevation. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl.