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| CAS No.: | 58-58-2 |
|---|---|
| Name: | PUROMYCIN DIHYDROCHLORIDE |
| Molecular Structure: | |
|
|
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| Formula: | C22H29 N7 O5 . 2 Cl H |
| Molecular Weight: | 544.438 |
| Synonyms: | Adenosine,3'-(a-amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyl-,dihydrochloride, L- (8CI); Adenosine,3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-,dihydrochloride (9CI); Adenosine,3'-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-,dihydrochloride, (S)-; 3'-(L-a-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosinedihydrochloride; CL 13900 dihydrochloride; CL 16,536; CL 16536; NSC 3055; P 638dihydrochloride; PDH; Puromycin dihydrochloride; Puromycin hydrochloride;Stylomycin dihydrochloride |
| EINECS: | 200-387-8 |
| Density: | g/cm3 |
| Melting Point: | 168-170℃ |
| Boiling Point: | °Cat760mmHg |
| Flash Point: | °C |
| Solubility: | Toxicity data (The meaning of any toxicological abb">
Stability
Toxicology
Toxicity data |
| Appearance: | white powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 22 |
| Safety: | Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and HCl. |
| PSA: | 160.88000 |
| LogP: | 1.09950 |
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Chemistry
IUPAC Name: 2-Amino-N-[(2S,3R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide dihydrochloride
The molecular formula of Puromycin dihydrochloride (CAS NO.58-58-2) is C22H31Cl2N7O5.
The molecular weight of Puromycin dihydrochloride (CAS NO.58-58-2) is 544.43.
Synonyms of Puromycin dihydrochloride (CAS NO.58-58-2): L-3'-(A-Amino-P-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine dihydrochloride ; Stylomycin dihydrochloride
Stability: Stable. Heat sensitive. Incompatible with strong oxidizing agents
Product Categories: Antibiotics
Appearance: white powder
Storage temp: -20 °C
Flash Point: 460.6 °C
Boiling Point: 838 °C
EINECS: 200-387-8
Uses
Puromycin dihydrochloride (CAS NO.58-58-2) is used as chemical reagent, organic intermediates, fine chemicals, pharmaceutical research and development.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | intramuscular | 202mg/kg (202mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
| guinea pig | LD50 | intramuscular | 202mg/kg (202mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
| guinea pig | LD50 | intraperitoneal | 287mg/kg (287mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
| guinea pig | LD50 | intraperitoneal | 287mg/kg (287mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
| guinea pig | LD50 | oral | 600mg/kg (600mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
| guinea pig | LD50 | oral | 600mg/kg (600mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
| mouse | LD50 | intraperitoneal | 580mg/kg (580mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
| mouse | LD50 | intraperitoneal | 580mg/kg (580mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
| mouse | LD50 | intravenous | 335mg/kg (335mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
| mouse | LD50 | intravenous | 335mg/kg (335mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
| mouse | LD50 | oral | 720mg/kg (720mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
| mouse | LD50 | oral | 720mg/kg (720mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
Safety Profile
Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and HCl.Safety information of Puromycin dihydrochloride (CAS NO.58-58-2):
Hazard Codes 
Xn
Risk Statements
22 Harmful if swallowed
40 Limited evidence of a carcinogenic effect
RIDADR 3249
WGK Germany 3
RTECS AU7355000
F 3-8-10
HazardClass 6.1(b)
PackingGroup III