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| CAS No.: | 58152-03-7 |
|---|---|
| Name: | Isepamicine |
| Article Data: | 2 |
| Molecular Structure: | |
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| Formula: | C22H43 N5 O12 |
| Molecular Weight: | 569.61 |
| Synonyms: | D-Streptamine,O-6-amino-6-deoxy-a-D-glucopyranosyl-(1®4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(1®6)]-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-;HAPA-B; Isepamicin; Isepamicine; Sch 21420 |
| EINECS: | 261-143-4 |
| Density: | 1.53g/cm3 |
| Boiling Point: | 926.8°Cat760mmHg |
| Flash Point: | 514.3°C |
| Safety: | Poison by intravenous route. Mildly toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 297.72000 |
| LogP: | -4.64170 |
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Chemistry
Product Name: Isepamicine
The MF of Isepamicine (CAS NO.58152-03-7) is C22H43N5O12.
The MW of Isepamicine (CAS NO.58152-03-7) is 569.6.
Synonyms of Isepamicine (CAS NO.58152-03-7): (s)-Y-1-Oxopropyl)-2-deoxy ; Hapa-b ; Hapa-gentamycinb ; Isepamicin ; Sch21420 ; Thyl-3-(methylamino)-beta-l-arabinopyranosyl-(1-6))-n(sup1)-(3-amino-2-hydrox ; (S)-O-6-Amino-6-deoxy-alpha-D-glucopyranosyl-(1->4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->6)]-1,3-diamino-N1-(3-aminolactoyl)-1,2,3-trideoxy-D-scyllo-inositol
Index of Refraction: 1.641
EINECS: 261-143-4
Density: 1.53 g/ml
Flash Point: 514.3 °C
Boiling Point: 926.8 °C
Uses
Isepamicine (CAS NO.58152-03-7) is semi-synthetic aminoglycoside antibiotics used for Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and other susceptible ones caused by sepsis, chronic bronchitis, bronchiectasis, infection, pneumonia, peritonitis and so on.
Production
Raw materials Ammonium hydroxide-->Trifluoroacetic acid-->Isepamicin sulfate
Toxicity Data With Reference
| 1. | ipr-mus LD50:5000 mg/kg | DRFUD4 Drugs of the Future. 4 (1979),525. | ||
| 2. | ivn-mus LD50:330 mg/kg | DRFUD4 Drugs of the Future. 4 (1979),525. |
Safety Profile
Poison by intravenous route. Mildly toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.