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| CAS No.: | 5874-97-5 |
|---|---|
| Name: | Orciprenaline sulfate |
| Molecular Structure: | |
 |
|
| Formula: | 2(C11H17NO3).H2SO4 |
| Molecular Weight: | 520.66 |
| Synonyms: | 3,5-Dihydroxy-alpha-((isopropylamino)methyl)-benzyl alcohol sulfate (2:1); Metaproterenol hemisulfate; Alupent |
| EINECS: | 227-539-6 |
| Density: | 1.199g/cm3 |
| Melting Point: | 202-203° |
| Boiling Point: | 417.5°Cat760mmHg |
| Flash Point: | 179.7°C |
| Hazard Symbols: | Xn |
| Risk Codes: | 20 |
| Safety: | Poison by subcutaneous and intravenous routes. Moderately toxic by intraduodenal route. Mildly toxic by ingestion. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx and SOx. See also SULFATES. |
| PSA: | 228.42000 |
| LogP: | 3.46820 |
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Chemistry
The IUPAC name of Metaproterenol sulfate (CAS NO.5874-97-5):
5-[1-Hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,3-diol; sulfuric acid
Synonyms: 1-(3,5-Dihydroxyphenyl)-1-hydroxy-2-isopropylaminoethanesulfate ; 1-(3,5-Dihydroxyphenyl)-2-(isopropylamino)ethanolsulfate ; 3,5-Dihydroxy-alpha-((isopropylamino)methyl)benzylalcoholsulfate ; 3,5-Dihydroxy-alpha-((isopropylamino)methyl)-benzylalcohosulfate(2:1) ; (s;3-Benzenediol,5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-sulfate(2:1) ; Alotec ; Metaprel ; Novasmasol
CAS: 5874-97-5
EINECS: 227-539-6
Molecular Formula: C22H36N2O10S
Formula Weight: 520.59 g/mol
Molecular Structure:
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Flash Point: 179.7 °C
Boiling Point: 417.5 °C at 760 mmHg
Uses
Orciprenaline (INN, also known as metaproterenol) is a bronchodilator used in the treatment of asthma. Orciprenaline is a moderately selective beta2-adrenergic receptor agonist that stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle, with minimal or no effect on alpha-adrenergic receptors. The pharmacologic effects of beta adrenergic agonist drugs, such as orciprenaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of ATP to cAMP. Increased cAMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from many cells, especially from mast cells.
Toxicity Data With Reference
The toxicity of Metaproterenol sulfate (CAS NO.5874-97-5):
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 114mg/kg (114mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 521, 1961. |
| mouse | LD50 | oral | 4800mg/kg (4800mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 521, 1961. |
| mouse | LD50 | subcutaneous | 290mg/kg (290mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 521, 1961. |
| rat | LD50 | intraduodenal | 2230mg/kg (2230mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. | |
| rat | LD50 | oral | 5538mg/kg (5538mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. | |
| rat | LD50 | subcutaneous | > 4gm/kg (4000mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. |
Safety Profile
The Hazard Codes of Metaproterenol sulfate (CAS NO.5874-97-5): 
Xn
Risk Statements:R20:Harmful by inhalation.
Safety Statements:S36:Wear suitable protective clothing.
Poison by subcutaneous and intravenous routes. Moderately toxic by intraduodenal route. Mildly toxic by ingestion. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx and SOx. See also SULFATES.