59467-70-8

The Midazolam, with the CAS registry number 59467-70-8, is also known as 8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine. It belongs to the product categories of Intermediates & Fine Chemicals; Pharmaceuticals; Aromatics; Heterocycles. This chemical's molecular formula is C₁₈H₁₃ClFN₃ and molecular weight is 325.77. What's more,Its systematic name is Midazolam.It is a White Crystaline Solid.And it is a short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.

Physical properties about Midazolam are:
(1)ACD/LogP:  3.798; (2)# of Rule of 5 Violations:  0; (3)ACD/LogD (pH 5.5):  3.23; (4)ACD/LogD (pH 7.4):  3.78; (5)ACD/BCF (pH 5.5):  123.20; (6)ACD/BCF (pH 7.4):  438.42; (7)ACD/KOC (pH 5.5):  753.79; (8)ACD/KOC (pH 7.4):  2682.51; (9)#H bond acceptors:  3; (10)#H bond donors:  0; (11)#Freely Rotating Bonds:  1; (12)Index of Refraction:  1.671; (13)Molar Refractivity:  89.654 cm³; (14)Molar Volume:  239.845 cm³; (15)Surface Tension:  46.1990013122559 dyne/cm; (16)Density:  1.358 g/cm³; (17)Flash Point:  254.295 °C; (18)Enthalpy of Vaporization:  76.472 kJ/mol; (19)Boiling Point:  496.865 °C at 760 mmHg; (20)Vapour Pressure:  0 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:Fc4ccccc4C/1=N/Cc3cnc(n3c2c\1cc(Cl)cc2)C;
(2)Std. InChI:InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3;
(3)Std. InChIKey:DDLIGBOFAVUZHB-UHFFFAOYSA-N.

The toxicity data of Midazolam as follows: