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CAS No.: | 59576-26-0 |
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Name: | 2-Acetyl-4-methylpyridine |
Article Data: | 12 |
Molecular Structure: | |
Formula: | C8H9NO |
Molecular Weight: | 135.166 |
Synonyms: | Ketone,methyl 4-methyl-2-pyridyl (6CI);1-(4-Methyl-2-pyridyl)-1-ethanone;Ethanone,1-(4-methyl-2-pyridinyl)-;4-Methyl-2-acetylpyridine; |
Density: | 1.036 g/cm3 |
Melting Point: | 30-34 °C(lit.) |
Boiling Point: | 227.1 °C at 760 mmHg |
Flash Point: | 96.5 °C |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-36 |
PSA: | 29.96000 |
LogP: | 1.59260 |
Conditions | Yield |
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Stage #1: 2-Bromo-4-picoline With n-butyllithium In diethyl ether; hexane at -78℃; for 0.166667 - 0.5h; Stage #2: N,N-dimethyl acetamide In diethyl ether; hexane at 20℃; for 2 - 14.5h; Product distribution / selectivity; | 59% |
Stage #1: 2-Bromo-4-picoline With n-butyllithium In diethyl ether; hexane at -78℃; for 0.166667h; Stage #2: N,N-dimethyl acetamide In diethyl ether; hexane at 20℃; for 14.5h; | 59% |
With n-butyllithium In diethyl ether; hexane | 37% |
Conditions | Yield |
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Stage #1: 2-Cyano-4-methylpyridin; methyl magnesium iodide In diethyl ether; benzene at 0 - 20℃; for 2h; Inert atmosphere; Stage #2: With water; ammonium chloride In diethyl ether; benzene Inert atmosphere; | 52% |
With diethyl ether; benzene Behandeln des Reaktionsgemisches mit wss.Ammoniumchlorid-Loesung; |
Conditions | Yield |
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With tert.-butylhydroperoxide; iron(II) sulfate; trifluoroacetic acid In acetonitrile for 4h; Heating; | 20% |
2-Bromo-4-picoline
2-acetyl-4-methylpyridine
A
2-acetyl-4-methylpyridine
Conditions | Yield |
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In tert-butyl alcohol; benzene for 5h; Irradiation; | |
In tert-butyl alcohol; benzene for 5h; Quantum yield; Irradiation; |
picoline
2-acetyl-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 30 percent / silver nitrate, ammonium persulfate, conc. H2SO4 / H2O; CH2Cl2 / 3 h / 40 °C 2: benzene; 2-methyl-propan-2-ol / 5 h / Irradiation View Scheme |
2-Amino-4-methylpyridine
2-acetyl-4-methylpyridine
Conditions | Yield |
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Multi-step reaction with 2 steps 1: diazonium reaction View Scheme |
Conditions | Yield |
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Stage #1: 2-Cyano-4-methylpyridin; methylmagnesium bromide In tetrahydrofuran; diethyl ether at -20 - -10℃; Stage #2: With hydrogenchloride; water In tetrahydrofuran; diethyl ether at -40℃; for 0.0833333h; |
2-acetyl-4-methylpyridine
2-aminobenzenesulfonic acid sodium salt
Conditions | Yield |
---|---|
In 5,5-dimethyl-1,3-cyclohexadiene; ethanol Reflux; | 97% |
Conditions | Yield |
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With sodium hydroxide In methanol; water at 20℃; for 2h; | 97% |
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Empirical Formula: C8H9NO
Molecular Weight: 135.1632
Freely Rotating Bonds: 1
Polar Surface Area: 29.96 Å2
Index of Refraction: 1.512
Molar Refractivity: 39.19 cm3
Molar Volume: 130.4 cm3
Polarizability: 15.53× 10-24 cm3
Surface Tension: 38.1 dyne/cm
Density: 1.036 g/cm3
Flash Point: 96.5 °C
Enthalpy of Vaporization: 46.37 kJ/mol
Melting Point: 30-34 °C(lit.)
Boiling Point: 227.1 °C at 760 mmHg
Vapour Pressure: 0.0788 mmHg at 25°C
The Cas Register Number of 2-Acetyl-4-methylpyridine is 59576-26-0.The chemical synonyms of 2-Acetyl-4-methylpyridine (CAS NO.59576-26-0) are 1-(4-Methyl-2-pyridinyl)ethanone and ethanone, 1-(4-methyl-2-pyridinyl)- .The molecular structure of 2-Acetyl-4-methylpyridine (CAS NO.59576-26-0) is
.
2-Acetyl-4-methylpyridine (CAS NO.59576-26-0) is used as organic intermediate .
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
WGK Germany: 3