CAS No.59803-98-4,Brimonidine Suppliers,MSDS download

Products Categories

Pharmaceutical (101)
Organic Chemicals (19)
Others (12)
Materials (3)
Reagent (2)

Basic Information

Molecular Structure:
CAS No.:	59803-98-4
Name:	Brimonidine
Article Data:	14

Formula:	C₁₁H₁₀BrN₅
Molecular Weight:	292.138
Synonyms:	5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline;AGN 190342;Bromoxidine;UK 14304-18;5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine;5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine;6-Quinoxalinamine, 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-;
Density:	1.82 g/cm³
Melting Point:	207.5 °C
Boiling Point:	432.6 °C at 760 mmHg
Flash Point:	215.4 °C
Appearance:	Yellow Solid
Hazard Symbols:	T
Risk Codes:	25-36/37/38
Safety:	26-36-45
Transport Information:	UN 2811 6.1/PG 3
PSA:	62.20000
LogP:	1.60080

Total:108 Page 1 of 3 1 2 3 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 59803-98-4

Specification

The Brimonidine, with the CAS registry number 59803-98-4, has the systematic name of 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine. It is a kind of yellow solid, and belongs to the following product categories: Brimonidine; Ophthalmic; Hetrerocycles; Intermediates & Fine Chemicals; Pharmaceuticals; Adrenoceptor. The molecular formula of this chemical is C₁₁H₁₀BrN₅.

The physical properties of Brimonidine are as following: (1)ACD/LogP: 0.15; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.49; (4)ACD/LogD (pH 7.4): 0.13; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 6.57; (8)ACD/KOC (pH 7.4): 27.44; (9)#H bond acceptors: 5; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 44.62 Å²; (13)Index of Refraction: 1.798; (14)Molar Refractivity: 68.41 cm³; (15)Molar Volume: 160.3 cm³; (16)Polarizability: 27.12×10^-24cm³; (17)Surface Tension: 66 dyne/cm; (18)Density: 1.82 g/cm³; (19)Flash Point: 215.4 °C; (20)Enthalpy of Vaporization: 68.84 kJ/mol; (21)Boiling Point: 432.6 °C at 760 mmHg; (22)Vapour Pressure: 1.1E-07 mmHg at 25°C.

Preparation of Brimonidine: It can start with condensation of 5-bromo-6-quinoline amines and ammonium thiocyanate. The resulting product reacts with ethylenediamin, and gives the aim product - Brimonidine.

Brimonidine can start with condensation of 5-bromo-6-quinoline amines and ammonium thiocyanate. The resulting product reacts with ethylenediamin, and gives the aim product - Brimonidine →Brimonidine

Uses of Brimonidine: It is a drug used to treat open-angle glaucoma or ocular hypertension. And as a treatment for glaucoma, it is usually given in eyedrop form. It is also an alpha 2 agonists, and inhibits the activity of adenylate cyclase. This reduces cAMP and hence aqueous humour production by the ciliary body.

You should be cautious while dealing with this chemical. It irritates eyes, respiratory system and skin, and it is also toxic if swallowed. Therefore, you had better take the following instructions: Wear suitable protective clothing, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: Brc2c1nccnc1ccc2N/C3=N/CCN3
(2)InChI: InChI=1/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
(3)InChIKey: XYLJNLCSTIOKRM-UHFFFAOYAG

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	160mg/kg (160mg/kg)		Japanese Kokai Tokyo Koho Patents. Vol. #81-02912,