CAS No.59804-37-4,Tenoxicam Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	59804-37-4
Name:	Tenoxicam
Article Data:	8

Formula:	C₁₃H₁₁N₃O₄S₂
Molecular Weight:	337.38
Synonyms:	Tenoxicam (JAN/USAN);Ro 12-0068/000;Tilcotil (TN);Tenoxicam [USAN:BAN:INN:JAN];2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide;Tenoxicamum [INN-Latin];(3Z)-3-[hydroxy-(pyridin-2-ylamino)methylidene]-4-methyl-5,5-dioxo-5$l^{6},9-dithia-4-azabicyclo[4.3.0]nona-7,10-dien-2-one;Ro 12-0068;Prestwick_849;4-Hydroxy-2-methyl-N-2-pyridinyl-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide;Tilcotil;Tenoxicam CP EP;4-Hydroxy-2-methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide-1,1-dioxide;
EINECS:	620-500-8
Density:	1.675 g/cm³
Melting Point:	209-213 °C
Solubility:	61.9mg/L(32 oC)
Appearance:	yellow crystalline powder
Hazard Symbols:	T,Xi
Risk Codes:	23/24/25-36/37/38
Safety:	36/37/39-45-36-26
PSA:	136.22000
LogP:	2.73420

Synthetic route

: 106820-67-1
4-hydroxy-N-2-pyridyl-2H-thieno<2,3-e>-1,2-thiazine-3-carboxamide 1,1-dioxide

: 616-38-6
carbonic acid dimethyl ester

: 59804-37-4
tenoxicam

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 7h; Large scale;	89%

: 504-29-0
2-aminopyridine

: 98827-44-2
methyl 4-hydroxy-2H-thieno<2,3-e>-1,2-thiazine-3-carboxylate 1,1-dioxide

: 616-38-6
carbonic acid dimethyl ester

: 59804-37-4
tenoxicam

Conditions

Conditions	Yield
Stage #1: methyl 4-hydroxy-2H-thieno<2,3-e>-1,2-thiazine-3-carboxylate 1,1-dioxide; carbonic acid dimethyl ester With potassium carbonate In N,N-dimethyl-formamide at 140℃; for 5h; Large scale; Stage #2: 2-aminopyridine With potassium carbonate In N,N-dimethyl-formamide for 7h; Large scale;	83%

...Expand

: 504-29-0
2-aminopyridine

: 59804-25-0
4-hydroxy-3-methoxycarbonyl-2-methyl-2H-thieno[2,3-e]-1,2-thiazine,1,1-dioxide

: 59804-37-4
tenoxicam

Conditions

Conditions	Yield
In 5,5-dimethyl-1,3-cyclohexadiene for 6h; Concentration; Reflux;	76.9%
In xylene for 7h; Heating;	75%

: 59337-89-2
3-chlorothiophene-2-carboxylic acid

: 59804-37-4
tenoxicam

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 210 g / 1.) sodium bisulfite, NaOH, CuCl, 2.) KCl / H2O / 16 h / 143 °C 2: POCl3, PCl5 / 1.5 h / Heating 3: 95 percent / CHCl3 / 3 h / Heating 4: 71 percent / pyridine / 4 h / Ambient temperature 5: 58 percent / CH3ONa / methanol; hexane / 6 h / Heating 6: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 16 h 7: 75 percent / xylene / 7 h / Heating View Scheme
Multi-step reaction with 6 steps 1: 210 g / 1.) sodium bisulfite, NaOH, CuCl, 2.) KCl / H2O / 16 h / 143 °C 2: POCl3, PCl5 / 1.5 h / Heating 3: 95 percent / CHCl3 / 3 h / Heating 4: 84 percent / pyridine / 2 h / Ambient temperature 5: 11 g / CH3ONa / methanol / a) RT, 15 min, b) reflux, 25 min 6: 75 percent / xylene / 7 h / Heating View Scheme

: 59337-92-7
2-(carbomethoxy)thiophene-3-sulfonyl chloride

: 59804-37-4
tenoxicam

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 71 percent / pyridine / 4 h / Ambient temperature 2: 58 percent / CH3ONa / methanol; hexane / 6 h / Heating 3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 16 h 4: 75 percent / xylene / 7 h / Heating View Scheme
Multi-step reaction with 3 steps 1: 84 percent / pyridine / 2 h / Ambient temperature 2: 11 g / CH3ONa / methanol / a) RT, 15 min, b) reflux, 25 min 3: 75 percent / xylene / 7 h / Heating View Scheme
Multi-step reaction with 4 steps 1: water / 6 h / 20 °C / pH 7 - 8 2: sodium methylate / methanol / 2 h / Reflux 3: sodium hydroxide / methanol / 3 h / 20 °C 4: 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux View Scheme

: 59337-91-6
3-chlorosulfonyl-thiophene-2-carboxylic acid chloride

: 59804-37-4
tenoxicam

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 95 percent / CHCl3 / 3 h / Heating 2: 71 percent / pyridine / 4 h / Ambient temperature 3: 58 percent / CH3ONa / methanol; hexane / 6 h / Heating 4: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 16 h 5: 75 percent / xylene / 7 h / Heating View Scheme
Multi-step reaction with 4 steps 1: 95 percent / CHCl3 / 3 h / Heating 2: 84 percent / pyridine / 2 h / Ambient temperature 3: 11 g / CH3ONa / methanol / a) RT, 15 min, b) reflux, 25 min 4: 75 percent / xylene / 7 h / Heating View Scheme

: 98827-44-2
methyl 4-hydroxy-2H-thieno<2,3-e>-1,2-thiazine-3-carboxylate 1,1-dioxide

: 59804-37-4
tenoxicam

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 16 h 2: 75 percent / xylene / 7 h / Heating View Scheme

: 106820-63-7
methyl 3-<<<(methoxcarbonyl)methyl>amino>sulfonyl>-2-thiophenecarboxylate

: 59804-37-4
tenoxicam

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 58 percent / CH3ONa / methanol; hexane / 6 h / Heating 2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 16 h 3: 75 percent / xylene / 7 h / Heating View Scheme
Multi-step reaction with 3 steps 1: sodium methylate / methanol / 2 h / Reflux 2: sodium hydroxide / methanol / 3 h / 20 °C 3: 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux View Scheme

: 59804-24-9
methyl 3-<-N-methylamino>sulfonyl>-2-thiophenecarboxylate

: 59804-37-4
tenoxicam

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 11 g / CH3ONa / methanol / a) RT, 15 min, b) reflux, 25 min 2: 75 percent / xylene / 7 h / Heating View Scheme

: dibutylbis[4-(hydroxy-κO)-2-methyl-N-(pyridin-2-yl-κN)-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxidato]tin

: [Sn(C4H9)2(C6H2S2NCH3O3C(O)NC5H4N)]*0.5CH3OH

B: 59804-37-4
tenoxicam

Conditions

Conditions	Yield
In methanol; acetonitrile slow crystn. of soln.;
In chloroform-d1

Raw Materials

504-29-0

Downstream Products

504-29-0

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Chemistry

Molecular structure of Tenoxicam (CAS NO.59804-37-4) is:

Product Name: Tenoxicam
CAS Registry Number: 59804-37-4
IUPAC Name: (3E)-3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxothieno[2,3-e]thiazin-4-one
Molecular Weight: 337.37414 [g/mol]
Molecular Formula: C₁₃H₁₁N₃O₄S₂
XLogP3-AA: 2.2
H-Bond Donor: 2
H-Bond Acceptor: 7
Melting Point: 209-2130 °C
Surface Tension: 91.737 dyne/cm
Density: 1.675 g/cm³
Product Categories: Active Pharmaceutical Ingredients;Tenoxicam;Intermediates & Fine Chemicals;Pharmaceuticals;Fused Ring Systems;Lipid signaling

Uses

Tenoxicam (CAS NO.59804-37-4) is used to relieve swelling, inflammation,stiffness, and pain associated with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis (a type of arthritis involving the spine), tendinitis (inflammation of a tendon), bursitis (inflammation of a bursa, a fluid-filled sac located around joints and near the bones), and periarthritis of the shoulders or hips (inflammation of tissues surrounding these joints).

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 128mg/kg (128mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 1030, 1987.
mouse	LD50	intraperitoneal	446mg/kg (446mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl,
mouse	LD50	oral	297mg/kg (297mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl,
mouse	LD50	subcutaneous	449mg/kg (449mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl,
rat	LD50	intraperitoneal	234mg/kg (234mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl,
rat	LD50	oral	79mg/kg (79mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl,
rat	LD50	subcutaneous	186mg/kg (186mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl,

Safety Profile

Hazard Codes: Toxic T, Irritant Xi
Risk Statements: 23/24/25-36/37/38
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 36/37/39-45-36-26
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 2
RTECS: XJ9095060

Specification

Tenoxicam , its cas register number is 59804-37-4. It also can be called 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide ; Mobiflex ; Tilcotil .It is a yellow crystalline powder.