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CAS No.: | 599-04-2 |
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Name: | D-(-)-PANTOLACTONE |
Molecular Structure: | |
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Formula: | C6H10O3 |
Molecular Weight: | 130.144 |
Synonyms: | 2(3H)-Furanone,dihydro-3-hydroxy-4,4-dimethyl-, (R)-;2(3H)-Furanone,dihydro-3-hydroxy-4,4-dimethyl-, D-(-)- (8CI);(-)-(R)-Pantolactone;(-)-2-Hydroxy-3,3-dimethyl-g-butyrolactone;(-)-Pantolactone;(-)-Pantoyl lactone;(3R)-Tetrahydro-3-hydroxy-4,4-dimethylfuran-2-one;(R)-(-)-Pantolactone;(R)-3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one;(R)-Pantolactone;(R)-a-Hydroxy-b,b-dimethyl-g-butyrolactone;D-(-)-Pantolactone;D-(-)-Pantoyl lactone;D-(-)-a-Hydroxy-b,b-dimethyl-g-butyrolactone;D-Pantolactone;D-Pantoyl lactone;Pantolactone;Pantothenic lactone;Pantoyl lactone; |
EINECS: | 209-963-3 |
Density: | 1.165 g/cm3 |
Melting Point: | 91 °C(lit.) |
Boiling Point: | 224.6 °C at 760 mmHg |
Flash Point: | 99 °C |
Solubility: | almost transparency |
Appearance: | White crystalline powder or crystals |
Safety: | 22-24/25 |
PSA: | 46.53000 |
LogP: | -0.06970 |
ketopantolactone
(R)-Pantolacton
Conditions | Yield |
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With chiral Rh complex derived from N,O-bis(dicyclopentylphosphinyl)-(S)-2-hydroxymethylindoline; hydrogen In toluene at 20℃; under 750.06 Torr; for 0.17h; | 100% |
With (R)-N-dicyclohexylphosphino-N-methyl-[(S)-2-(diphenylphosphino)ferrocenyl]ethylamine; hydrogen; bis(cycloocta-1,5-diene)rhodium(I) trifluoromethanesulfonate In ethyl acetate at 25℃; under 15514.4 Torr; for 1.25h; | 99% |
With D-glucose; Rhodotorula minuta IFO 0920 at 28℃; for 36h; | 80.3% |
(R)-Pantolacton
Conditions | Yield |
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With hydrogenchloride In water at 20℃; for 0.5h; pH=1 - 2; Reagent/catalyst; | 96.9% |
(R)-2,4-dihydroxy-N-<(1R)-2-endo-hydroxy-3-endo-bornyl>-3,3-dimethylbutyramide
(R)-Pantolacton
Conditions | Yield |
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With sodium hydroxide In ethanol; water at 40℃; for 1h; | 96.8% |
ketopantolactone
A
(S)-pantolactone
B
(R)-Pantolacton
Conditions | Yield |
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With hydrogen; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (2S,4S)-N-butoxycarbonyl-4-diphenylphosphino-2-diphenylphosphinomethylpyrrolidine In toluene at 50℃; under 37503 Torr; for 45h; Yields of byproduct given. Title compound not separated from byproducts; | A n/a B 95% |
With hydrogen; (S)-Cp-isoAlaNOP - 2 In toluene at 20℃; under 760 Torr; for 0.5h; Title compound not separated from byproducts; | |
With magnesium(II) perchlorate; (S)-3-(N,N-dimethylcarbamoyl)-1,2,4-trimethyl-1,4-dihydropyridine In [D3]acetonitrile -25 degC to r.t, 1 h; |
D-sodium pantoate
(R)-Pantolacton
Conditions | Yield |
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With hydrogenchloride In water at 20℃; for 0.5h; pH=1 - 2; Reagent/catalyst; | 94.7% |
3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one
(R)-Pantolacton
Conditions | Yield |
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With phosphomolybdic acid hydrate; silica gel In tetrahydrofuran at 20℃; for 12h; | 94% |
With iron(III) p-toluenesulfonate hexahydrate In methanol for 27.5833h; Reflux; chemoselective reaction; | 84% |
(R)-(+)-3-(Benzyloxy)-4,5-dihydro-4,4-dimethyl-furan-2(3H)-on
(R)-Pantolacton
Conditions | Yield |
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With palladium 10% on activated carbon; hydrogen In methanol optical yield given as %ee; | 93% |
2(R)-hydroxy-3,3-dimethyl-4-oxo-butxyric acid ethyl ester
(R)-Pantolacton
Conditions | Yield |
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With sodium tetrahydroborate In methanol at 0℃; | 93% |
With sodium cyanoborohydride In methanol Reagent/catalyst; Solvent; Cooling with ice; | 93% |
Multi-step reaction with 2 steps 1.1: sodium tetrahydroborate / diethyl ether / 20 °C 1.2: Saturated solution 2.1: toluene-4-sulfonic acid / diethyl ether / 20 °C View Scheme | |
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; (R)-N-(2-hydroxyethyl)pyrrolidine-2-carboxamide; sodium formate In water; tert-butyl alcohol at 40℃; for 1h; Temperature; Reagent/catalyst; Inert atmosphere; |
(R)-Pantolacton
Conditions | Yield |
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With hydrogenchloride at 115℃; for 5h; | 88% |
(R)-Pantolacton
Conditions | Yield |
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With sodium tetrahydroborate In ethanol Cooling with ice; | 87% |
The 2(3H)-Furanone,dihydro-3-hydroxy-4,4-dimethyl-, (3R)-, with CAS registry number 599-04-2, belongs to the following product category: Pharmaceutical Intermediates. It has the systematic name of 3-hydroxy-4,4-dimethyldihydrofuran-2(3H)-one. This chemical is a kind of white crystalline powder or crystals. And it should be stored at the temperature of 2-8°C. When use it, do not breathe dust and avoid contact with skin and eyes.
Physical properties of 2(3H)-Furanone,dihydro-3-hydroxy-4,4-dimethyl-, (3R)-: (1)ACD/LogP: -0.80; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.8; (4)ACD/LogD (pH 7.4): -0.8; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 8.74; (8)ACD/KOC (pH 7.4): 8.74; (9)#H bond acceptors: 3; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 35.53 Å2; (13)Index of Refraction: 1.468; (14)Molar Refractivity: 31.09 cm3; (15)Molar Volume: 111.6 cm3; (16)Polarizability: 12.32×10-24cm3; (17)Surface Tension: 38.1 dyne/cm; (18)Density: 1.165 g/cm3; (19)Flash Point: 99 °C; (20)Enthalpy of Vaporization: 53.61 kJ/mol; (21)Boiling Point: 224.6 °C at 760 mmHg; (22)Vapour Pressure: 0.0181 mmHg at 25°C.
Preparation: this chemical can be prepared by (2S)-3,3-Dimethylbernsteinsaeure-4-methylester. This reaction will need reagent (C2H5)3LiBH and solvent tetrahydrofuran. The yield is about 70%.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C1OCC(C)(C)C1O
(2)InChI: InChI=1/C6H10O3/c1-6(2)3-9-5(8)4(6)7/h4,7H,3H2,1-2H3
(3)InChIKey: SERHXTVXHNVDKA-UHFFFAOYAN
(4)Std. InChI: InChI=1S/C6H10O3/c1-6(2)3-9-5(8)4(6)7/h4,7H,3H2,1-2H3
(5)Std. InChIKey: SERHXTVXHNVDKA-UHFFFAOYSA-N