Products Categories
| CAS No.: | 599-04-2 |
|---|---|
| Name: | D-(-)-PANTOLACTONE |
| Molecular Structure: | |
|
|
|
| Formula: | C6H10O3 |
| Molecular Weight: | 130.144 |
| Synonyms: | 2(3H)-Furanone,dihydro-3-hydroxy-4,4-dimethyl-, (R)-;2(3H)-Furanone,dihydro-3-hydroxy-4,4-dimethyl-, D-(-)- (8CI);(-)-(R)-Pantolactone;(-)-2-Hydroxy-3,3-dimethyl-g-butyrolactone;(-)-Pantolactone;(-)-Pantoyl lactone;(3R)-Tetrahydro-3-hydroxy-4,4-dimethylfuran-2-one;(R)-(-)-Pantolactone;(R)-3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one;(R)-Pantolactone;(R)-a-Hydroxy-b,b-dimethyl-g-butyrolactone;D-(-)-Pantolactone;D-(-)-Pantoyl lactone;D-(-)-a-Hydroxy-b,b-dimethyl-g-butyrolactone;D-Pantolactone;D-Pantoyl lactone;Pantolactone;Pantothenic lactone;Pantoyl lactone; |
| EINECS: | 209-963-3 |
| Density: | 1.165 g/cm3 |
| Melting Point: | 91 °C(lit.) |
| Boiling Point: | 224.6 °C at 760 mmHg |
| Flash Point: | 99 °C |
| Solubility: | almost transparency |
| Appearance: | White crystalline powder or crystals |
| Safety: | 22-24/25 |
| PSA: | 46.53000 |
| LogP: | -0.06970 |
- 81281-59-67-Benzylideneaminotheophylline
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 717878-06-31-(4-fluorophenyl)-4-nitro-1H-imidazole
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
- 13031-04-4
ketopantolactone
- 599-04-2
(R)-Pantolacton
| Conditions | Yield |
|---|---|
| With chiral Rh complex derived from N,O-bis(dicyclopentylphosphinyl)-(S)-2-hydroxymethylindoline; hydrogen In toluene at 20℃; under 750.06 Torr; for 0.17h; | 100% |
| With (R)-N-dicyclohexylphosphino-N-methyl-[(S)-2-(diphenylphosphino)ferrocenyl]ethylamine; hydrogen; bis(cycloocta-1,5-diene)rhodium(I) trifluoromethanesulfonate In ethyl acetate at 25℃; under 15514.4 Torr; for 1.25h; | 99% |
| With D-glucose; Rhodotorula minuta IFO 0920 at 28℃; for 36h; | 80.3% |
- 599-04-2
(R)-Pantolacton
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water at 20℃; for 0.5h; pH=1 - 2; Reagent/catalyst; | 96.9% |
- 107730-03-0
(R)-2,4-dihydroxy-N-<(1R)-2-endo-hydroxy-3-endo-bornyl>-3,3-dimethylbutyramide
- 599-04-2
(R)-Pantolacton
| Conditions | Yield |
|---|---|
| With sodium hydroxide In ethanol; water at 40℃; for 1h; | 96.8% |
- 13031-04-4
ketopantolactone
A
- 79-50-5, 599-04-2, 5405-40-3, 52126-90-6
(S)-pantolactone
B
- 599-04-2
(R)-Pantolacton
| Conditions | Yield |
|---|---|
| With hydrogen; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (2S,4S)-N-butoxycarbonyl-4-diphenylphosphino-2-diphenylphosphinomethylpyrrolidine In toluene at 50℃; under 37503 Torr; for 45h; Yields of byproduct given. Title compound not separated from byproducts; | A n/a B 95% |
| With hydrogen; (S)-Cp-isoAlaNOP - 2 In toluene at 20℃; under 760 Torr; for 0.5h; Title compound not separated from byproducts; | |
| With magnesium(II) perchlorate; (S)-3-(N,N-dimethylcarbamoyl)-1,2,4-trimethyl-1,4-dihydropyridine In [D3]acetonitrile -25 degC to r.t, 1 h; |
- 60979-68-2
D-sodium pantoate
- 599-04-2
(R)-Pantolacton
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water at 20℃; for 0.5h; pH=1 - 2; Reagent/catalyst; | 94.7% |
- 133094-78-7
3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one
- 599-04-2
(R)-Pantolacton
| Conditions | Yield |
|---|---|
| With phosphomolybdic acid hydrate; silica gel In tetrahydrofuran at 20℃; for 12h; | 94% |
| With iron(III) p-toluenesulfonate hexahydrate In methanol for 27.5833h; Reflux; chemoselective reaction; | 84% |
- 20374-33-8
(R)-(+)-3-(Benzyloxy)-4,5-dihydro-4,4-dimethyl-furan-2(3H)-on
- 599-04-2
(R)-Pantolacton
| Conditions | Yield |
|---|---|
| With palladium 10% on activated carbon; hydrogen In methanol optical yield given as %ee; | 93% |
- 1196498-52-8
2(R)-hydroxy-3,3-dimethyl-4-oxo-butxyric acid ethyl ester
- 599-04-2
(R)-Pantolacton
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate In methanol at 0℃; | 93% |
| With sodium cyanoborohydride In methanol Reagent/catalyst; Solvent; Cooling with ice; | 93% |
| Multi-step reaction with 2 steps 1.1: sodium tetrahydroborate / diethyl ether / 20 °C 1.2: Saturated solution 2.1: toluene-4-sulfonic acid / diethyl ether / 20 °C View Scheme | |
| With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; (R)-N-(2-hydroxyethyl)pyrrolidine-2-carboxamide; sodium formate In water; tert-butyl alcohol at 40℃; for 1h; Temperature; Reagent/catalyst; Inert atmosphere; |
- 599-04-2
(R)-Pantolacton
| Conditions | Yield |
|---|---|
| With hydrogenchloride at 115℃; for 5h; | 88% |
- 599-04-2
(R)-Pantolacton
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate In ethanol Cooling with ice; | 87% |
- 59938-06-61-Ethoxy-3-trifluoromethyl-1,3-butadiene
- 5995-29-9[(hexylimino)bis(methylene)]bisphosphonic acid
- 5995-42-6[[(2-hydroxyethyl)imino]bis(methylene)]bisphosphonic acid
- 5995-86-8Gallic acid monohydrate
- 599-61-13,3'-Sulfonyldianiline
- 59978-22-2Barium zirconium sulfide
- 59987-31-45-Amino-2,4-dichloropyrimidine
- 60112-98-34-[2-(4-hydroxyphenyl)propan-2-yl]phenol
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
What can I do for you?
Get Best Price
Specification
The 2(3H)-Furanone,dihydro-3-hydroxy-4,4-dimethyl-, (3R)-, with CAS registry number 599-04-2, belongs to the following product category: Pharmaceutical Intermediates. It has the systematic name of 3-hydroxy-4,4-dimethyldihydrofuran-2(3H)-one. This chemical is a kind of white crystalline powder or crystals. And it should be stored at the temperature of 2-8°C. When use it, do not breathe dust and avoid contact with skin and eyes.
Physical properties of 2(3H)-Furanone,dihydro-3-hydroxy-4,4-dimethyl-, (3R)-: (1)ACD/LogP: -0.80; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.8; (4)ACD/LogD (pH 7.4): -0.8; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 8.74; (8)ACD/KOC (pH 7.4): 8.74; (9)#H bond acceptors: 3; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 35.53 Å2; (13)Index of Refraction: 1.468; (14)Molar Refractivity: 31.09 cm3; (15)Molar Volume: 111.6 cm3; (16)Polarizability: 12.32×10-24cm3; (17)Surface Tension: 38.1 dyne/cm; (18)Density: 1.165 g/cm3; (19)Flash Point: 99 °C; (20)Enthalpy of Vaporization: 53.61 kJ/mol; (21)Boiling Point: 224.6 °C at 760 mmHg; (22)Vapour Pressure: 0.0181 mmHg at 25°C.
Preparation: this chemical can be prepared by (2S)-3,3-Dimethylbernsteinsaeure-4-methylester. This reaction will need reagent (C2H5)3LiBH and solvent tetrahydrofuran. The yield is about 70%.
.jpg)
You can still convert the following datas into molecular structure:
(1)SMILES: O=C1OCC(C)(C)C1O
(2)InChI: InChI=1/C6H10O3/c1-6(2)3-9-5(8)4(6)7/h4,7H,3H2,1-2H3
(3)InChIKey: SERHXTVXHNVDKA-UHFFFAOYAN
(4)Std. InChI: InChI=1S/C6H10O3/c1-6(2)3-9-5(8)4(6)7/h4,7H,3H2,1-2H3
(5)Std. InChIKey: SERHXTVXHNVDKA-UHFFFAOYSA-N