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| CAS No.: | 60-87-7 |
|---|---|
| Name: | PROMETHAZINE |
| Article Data: | 29 |
| Molecular Structure: | |
|
|
|
| Formula: | C17H20 N2 S |
| Molecular Weight: | 284.425 |
| Synonyms: | Phenothiazine,10-[2-(dimethylamino)propyl]- (8CI);(2-Dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine; (?à)-Promethazine;10-[2-(Dimethylamino)propyl]phenothiazine; Dimapp; Diphergan; NSC 30321;Proazamine; Procit; Prometazin; Promethazine; Protazine; Prothazin; RP 3277;Vallergine |
| Density: | 1.131 |
| Melting Point: | 60 |
| Boiling Point: | 190-192oC at 3 mm Hg |
| Solubility: | 383.9ug/L(22.5 oC) |
| Safety: | Poison by ingestion, intravenous, intramuscular, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: pupillary dilation, wakefulness, hallucinations, and distorted perceptions. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A severe eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx. |
| PSA: | 31.78000 |
| LogP: | 4.30440 |
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| Conditions | Yield |
|---|---|
| With sodium hydrogencarbonate In dichloromethane; water Reagent/catalyst; | 96% |
| With sodium hydroxide In diethyl ether Purification / work up; | 90% |
- 124-40-3
dimethyl amine
- 15375-56-1
1-(10H-phenothiazin-10-yl)acetone
- 60-87-7
10-[2-(dimethylamino)propyl]phenothiazine
| Conditions | Yield |
|---|---|
| With sodium tris(acetoxy)borohydride In N,N-dimethyl acetamide at 50℃; | 75% |
- 92-84-2
10H-phenothiazine
- 17256-39-2
2-(dimethyl-amino)-1-methylethylchloride hydrochloride
- 60-87-7
10-[2-(dimethylamino)propyl]phenothiazine
| Conditions | Yield |
|---|---|
| With potassium hydroxide; Aliquat 336 at 80℃; for 1h; | 71% |
- 92-84-2
10H-phenothiazine
- 108-14-5
2-chloro-1-dimethylaminopropane
- 60-87-7
10-[2-(dimethylamino)propyl]phenothiazine
| Conditions | Yield |
|---|---|
| racemat; | |
| racemat; |
- 92-84-2
10H-phenothiazine
- 108-14-5
2-chloro-1-dimethylaminopropane
A
- 303-14-0
isopromethazine
B
- 60-87-7
10-[2-(dimethylamino)propyl]phenothiazine
| Conditions | Yield |
|---|---|
| racemat; |
- 92-84-2
10H-phenothiazine
- 53309-35-6
(2-chloro-1-methyl-ethyl)-dimethyl-amine
- 60-87-7
10-[2-(dimethylamino)propyl]phenothiazine
| Conditions | Yield |
|---|---|
| (i) NaNH2, toluene, (ii) /BRN= 505990/; Multistep reaction; |
- 72332-06-0
2-<2-(dimethylamino)propyl> phenothiazine-10-carboxylate
A
- 92-84-2
10H-phenothiazine
B
- 303-14-0
isopromethazine
C
- 60-87-7
10-[2-(dimethylamino)propyl]phenothiazine
| Conditions | Yield |
|---|---|
| at 180 - 220℃; for 2.5h; | A 840 mg B 148 mg C 454 mg |
| at 180 - 220℃; for 2.5h; Mechanism; | A 840 mg B 148 mg C 454 mg |
- 38878-40-9
promethazine cation
- 60-87-7
10-[2-(dimethylamino)propyl]phenothiazine
| Conditions | Yield |
|---|---|
| With hydrogen sulfite In water Rate constant; Irradiation; variation of pH; |
| Conditions | Yield |
|---|---|
| With water Product distribution; Mechanism; pH 7; var. phenothiazine cation radicals, var. buffers; |
- 60-87-7
10-[2-(dimethylamino)propyl]phenothiazine
| Conditions | Yield |
|---|---|
| With copper; potassium carbonate; N,N-dimethyl-formamide racemat; |
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Chemistry
Chemical Name: Promethazine
IUPAC NAME: N,N-Dimethyl-1-phenothiazin-10-ylpropan-2-amine
CAS No.: 60-87-7
EINECS: 200-489-2
Molecular Formula: C17H20N2S
Molecular Weight: 284.42 g/mol
Density: 1.131 g/cm3
Flash Point: 198 °C
Boiling Point: 403.7 °C at 760 mmHg
Following is the structure of 10-(2-(Dimethylamino)propyl)pheno-thiazine (CAS No.60-87-7):
The chemical synonymous of 10-(2-(Dimethylamino)propyl)pheno-thiazine (CAS No.60-87-7) are (2-Dimethylamino-2-Methyl)Ethyl-N-Dibenzoparathiazine ; (Dimethylamino-2-Propyl-10-Phenothiazine Hydrochloride ; 10-(2-(Dimethylamino)-2-Methylethyl)Phenothiazine ; 10-[2-(Dimethylamino)Propyl]Phenothiazine ; 10h-Phenothiazine-10-Ethanamine, N,N,Alpha-Trimethyl-
Toxicity Data With Reference
| 1. | eye-rbt 100 mg SEV | FCTOD7 Food and Chemical Toxicology. 20 (1982),573. | ||
| 2. | eye-rbt 100 mg/4S rns MLD | FCTOD7 Food and Chemical Toxicology. 20 (1982),573. | ||
| 3. | dni-hmn:fbr 80 nmol/L | DNSYAG Diseases of the Nervous System. 29 (1968),829. | ||
| 4. | otr-ham:emb 10 mg/L | ENMUDM Environmental Mutagenesis. 8 (Suppl 6)(1986),4. | ||
| 5. | msc-ham:lng 10 mg/L | SHIGAZ Shigaku. Ondotology. 70 (1983),943. | ||
| 6. | skn-cld TDLo:13 mg/kg:EYE,PSY | CMAJAX Canadian Medical Association Journal. 130 (1984),1460. | ||
| 7. | ipr-rat LDLo:140 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 1 (1959),156. | ||
| 8. | scu-rat LD50:700 mg/kg | CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. 144 (1950),887. | ||
| 9. | ivn-rat LD50:45 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 120 (1959),450. | ||
| 10. | ims-rat LD50:169 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 18 (1971),185. | ||
| 11. | & |
Safety Profile
Poison by ingestion, intravenous, intramuscular, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: pupillary dilation, wakefulness, hallucinations, and distorted perceptions. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A severe eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx.