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CAS No.: | 6051-41-8 |
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Name: | Benzamide, 4-formyl- |
Article Data: | 45 |
Molecular Structure: | |
Formula: | C8H7 N O2 |
Molecular Weight: | 149.149 |
Synonyms: | Terephthalaldehydamide(8CI); 4-Aminocarbonylbenzaldehyde; 4-Carbamoylbenzaldehyde; 4-Formylbenzamide |
Density: | 1.2021 (rough estimate) |
Melting Point: | 153-158℃ |
Boiling Point: | 290.25°C (rough estimate) |
Hazard Symbols: | Xi |
Risk Codes: | R36/37/38; |
PSA: | 60.16000 |
LogP: | 1.29830 |
Conditions | Yield |
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With manganese(IV) oxide; water In isopropyl alcohol at 100℃; under 5171.62 Torr; for 0.333333h; | 99% |
With [RuH(tBu-PNP(-))(CO)]; water In tetrahydrofuran; tert-butyl alcohol at 20℃; for 24h; | 99% |
With sodium perborate In ethanol; water for 0.0333333h; microwave irradiation; | 97% |
4-formylbenzamide
Conditions | Yield |
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With benzyltriethylammonium tetrathiomolybdate In water; acetonitrile at 25℃; for 3h; | 88% |
dicobalt octacarbonyl
4-bromo-benzaldehyde
4-formylbenzamide
Conditions | Yield |
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With 1H-imidazole; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; ammonium chloride; N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 90℃; for 3h; Sealed tube; | 82% |
Conditions | Yield |
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With carbon tetrabromide; oxygen In acetonitrile at 20℃; for 3.5h; Irradiation; Green chemistry; | 79% |
dicobalt octacarbonyl
p-(iodophenyl)carboxaldehyde
4-formylbenzamide
Conditions | Yield |
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With 1H-imidazole; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; ammonium chloride; N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 90℃; for 3h; Sealed tube; | 77% |
Conditions | Yield |
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With tert.-butylhydroperoxide; sodium carbonate; ammonium chloride In acetonitrile at 50℃; for 0.666667h; Inert atmosphere; Green chemistry; | 76% |
Conditions | Yield |
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With tris-(dibenzylideneacetone)dipalladium(0); (2R)-1-[(1R)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene; ammonium carbamate; sodium hydrogencarbonate In 1,4-dioxane at 100℃; for 20h; Inert atmosphere; | 65% |
Conditions | Yield |
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Stage #1: 4-Carboxybenzaldehyde With 4-methyl-morpholine In dichloromethane at 0℃; Stage #2: With isobutyl chloroformate at 0℃; for 0.5h; Stage #3: With ammonium hydroxide at 0℃; for 1h; | 48% |
Stage #1: 4-Carboxybenzaldehyde With 4-methyl-morpholine; chloroformic acid ethyl ester In tetrahydrofuran at -5 - 0℃; for 0.583333h; Stage #2: With ammonia In tetrahydrofuran; 1,4-dioxane at -5 - 0℃; for 0.616667h; | 33% |
Stage #1: 4-Carboxybenzaldehyde In tetrahydrofuran at 0℃; for 16h; Stage #2: With ammonia In tetrahydrofuran; water | 30% |
Multi-step reaction with 2 steps 1: Vilsmeier reagent / tetrahydrofuran / 16 h / 0 °C 2: ammonia / water / Cooling View Scheme |
tert-butyl 4-(chloromethyl)benzamide
4-formylbenzamide
Conditions | Yield |
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With 4-methylmorpholine N-oxide In tetrahydrofuran at 20℃; for 12h; Reflux; | 45% |
Conditions | Yield |
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With sulfuric acid |