CAS No.608-07-1,5-Methoxytryptamine Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	608-07-1
Name:	5-Methoxytryptamine
Article Data:	68

Formula:	C₁₁H₁₄N₂O
Molecular Weight:	190.245
Synonyms:	Indole,3-(2-aminoethyl)-5-methoxy- (6CI,8CI);2-(5-Methoxyindol-3-yl)ethylamine;2-[5-(Methyloxy)-1H-indol-3-yl]ethanamine;3-(2-Aminoethyl)-5-methoxyindole;5-MOT;5-Methoxy-1H-indole-3-ethanamine;Deacetylmelatonin;Methoxytryptamine;NSC 56422;[2-(5-Methoxy-1H-indol-3-yl)ethyl]amine;
EINECS:	210-153-7
Density:	1.0815 (rough estimate)
Melting Point:	245-250 °C (dec.)(lit.)
Boiling Point:	380oC
Appearance:	White to tan crystalline powder
Hazard Symbols:	Xn
Risk Codes:	22-36/37/38-20/21/22
Safety:	36-26
PSA:	51.04000
LogP:	2.37800

Synthetic route

: 68935-49-9
5-methoxy-3-(2-nitroethyl)-1H-indole

: 608-07-1
2-(5-methoxyindol-3-yl)ethylamine

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen In methanol at 20℃;	99%
With hydrogen; palladium on activated charcoal In ethanol under 2585.7 Torr; for 12h;

: 67199-10-4
methyl N-[2-(5-methoxy-1H-indol-3-yl)ethyl]carbamate

: 608-07-1
2-(5-methoxyindol-3-yl)ethylamine

Conditions

Conditions	Yield
With sodium hydroxide In methanol for 4h; Hydrolysis; decarboxylation; Heating;	99%
With water Hydrolysis;
With sodium hydroxide Heating;

: 55747-53-0
2-ethoxycarbonyl-3-(2-phthalimidoethyl)-5-methoxyindole

: 608-07-1
2-(5-methoxyindol-3-yl)ethylamine

Conditions

Conditions	Yield
Stage #1: 2-ethoxycarbonyl-3-(2-phthalimidoethyl)-5-methoxyindole With water; sodium hydroxide at 88 - 90℃; Stage #2: With hydrogenchloride In water at 10 - 110℃; Temperature;	99%
Multi-step reaction with 2 steps 1: 10 percent aq. NaOH / 0.08 h / Heating; microwave irradiation 2: 20 percent H2SO4 / 0.17 h / Heating; microwave irradiation View Scheme
With potassium hydroxide for 3h; Reflux;	57 g

: 73-31-4
5-methoxy-N-acetyl-tryptamine

: 608-07-1
2-(5-methoxyindol-3-yl)ethylamine

Conditions

Conditions	Yield
With ammonium bromide; ethylenediamine at 100℃; for 7h; Microwave irradiation;	89%
With sulfuric acid In water for 8h; Heating;	69.7%
With sodium hydroxide In 2-methyl-propan-1-ol

: 627086-10-6
2-(1-methanesulfonyl-5-methoxy-1H-indol-3-yl)ethylamine

: 608-07-1
2-(5-methoxyindol-3-yl)ethylamine

Conditions

Conditions	Yield
With potassium hydroxide In methanol for 9h; Heating;	84%

: 61675-19-2
5-methoxy-3-(2-nitro-vinyl)-indole

: 608-07-1
2-(5-methoxyindol-3-yl)ethylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 40h;	73%
With lithium aluminium tetrahydride In tetrahydrofuran Heating;
Stage #1: 5-methoxy-3-(2-nitro-vinyl)-indole With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; Inert atmosphere; Stage #2: With water In tetrahydrofuran at 0℃;

: 40619-73-6
2-(1-benzyl-5-methoxy-1H-indol-3-yl)ethylamine

: 608-07-1
2-(5-methoxyindol-3-yl)ethylamine

Conditions

Conditions	Yield
With sodium In tetrahydrofuran; ammonia at -33℃; for 1.5h;	66%

: 102016-76-2
N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-4-methylbenzenesulfonamide

: 608-07-1
2-(5-methoxyindol-3-yl)ethylamine

Conditions

Conditions	Yield
With ammonia; sodium In tetrahydrofuran at -78℃; for 0.25h;	65%

: 1006-94-6
5-methoxylindole

: 56-45-1
L-serin

: 608-07-1
2-(5-methoxyindol-3-yl)ethylamine

Conditions

Conditions	Yield
Stage #1: 5-methoxylindole; L-serin With engineered tryptophan synthase In methanol; aq. phosphate buffer at 75℃; for 12h; pH=8.0; Enzymatic reaction; Stage #2: With pyridoxal 5'-phosphate; Ruminococcus gnavus L-tryptophan decarboxylase In methanol; aq. phosphate buffer at 37℃; pH=8.0; Enzymatic reaction;	14%

: 1006-94-6
5-methoxylindole

: 917-64-6
methyl magnesium iodide

: 60-29-7
diethyl ether

: 107-14-2
chloroacetonitrile

: 608-07-1
2-(5-methoxyindol-3-yl)ethylamine

Conditions

Conditions	Yield
und Erwaermen des Reaktionsprodukts Natrium in Aethanol;

...Expand

Raw Materials

73-31-4

Downstream Products

73-31-4

Total:184 Page 1 of 5 1 2 3 4 5 Next>>

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Chemistry

Molecular Structure:

Molecular Formula: C₁₁H₁₀NO₃
Molecular Weight: 204.202
IUPAC Name: 2-(5-Methoxy-1H-indol-3-yl)ethanamine
Synonyms of 5-Methoxytryptamine (CAS NO.608-07-1): 3-(2-Aminoethyl)-5-methoxyindole ; 5-22-12-00018 (Beilstein Handbook Reference) ; 5-Mot ; 5MOT ; BRN 0145587 ; EINECS 210-153-7 ; Meksamin (free base) ; Methoxytryptamine ; Mexamine ; Mexamine base ; NSC 56422 ; 1H-Indole-3-ethanamine, 5-methoxy- (9CI) ; 2-(5-Methoxyindol-3-yl)ethylamine ; Indole, 3-(2-aminoethyl)-5-methoxy-
CAS NO: 608-07-1
Classification Code: Drug / Therapeutic Agent ; Mutation data ; Reproductive Effect
Melting point: 245-250 °C
Storage temp.: 2-8°C
Form: crystalline
Color: white
Merck: 13,6032

Uses

5-Methoxytryptamine (CAS NO.608-07-1) is used as intermediates in organic synthesis.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	176mg/kg (176mg/kg)		Journal of Toxicology and Environmental Health. Vol. 1, Pg. 515, 1976.
mouse	LD50	intravenous	106mg/kg (106mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Farmakologiya i Toksikologiya Vol. 27, Pg. 681, 1964.

Safety Profile

Safety Information of 5-Methoxytryptamine (CAS NO.608-07-1):
Hazard Codes:Xn
Risk Statements:22-36/37/38-20/21/22
22:Harmful if swallowed
36/37/38:Irritating to eyes, respiratory system and skin
20/21/22:Harmful by inhalation, in contact with skin and if swallowed
Safety Statements:36-26
36:Wear suitable protective clothing
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany:3
RTECS:NL4110000
F:8
Poison by intravenous and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.

Specification

First Aid Measures of 5-Methoxytryptamine (CAS NO.608-07-1):
Ingestion:If swallowed, wash out mouth with water provided person is conscious. Call a physician.
Inhalation:If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
Skin:In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
Eyes:In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.
Storage of 5-Methoxytryptamine (CAS NO.608-07-1):
Keep tightly closed.