Products Categories
| CAS No.: | 61-25-6 |
|---|---|
| Name: | Papaverine hydrochloride |
| Article Data: | 7 |
| Molecular Structure: | |
|
|
|
| Formula: | C20H21NO4.HCl |
| Molecular Weight: | 375.852 |
| Synonyms: | Vasal;Vasorin;Spasmo Nit;Therapav;Paveron;Ro-Papav;Pavadel;Pavagen;Pavakey;Pavased;Vasospan;1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride;6,7,3',4'-Tetramethoxy-1-benzylisoquinoline hydrochloride;6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)isoquinoline hydrochloride;Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-, hydrochloride (9CI);Isoquinoline, 6,7-dimethoxy-1-veratryl-, hydrochloride (8CI);6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride;Papaverine hydrochloride;Papaverinium chloride;Papaversan;Paptial TR;Pavabid;Pavacap;Pavacen;Artegodan;Cardiospan;Cardoverina;Cepaverin;Cerebid;Cerespan;Dispamil;Drapavel;Dynovas;Myobid;Optenyl;Pameion;Panergon;Papavarine chlorhydrate; |
| EINECS: | 200-502-1 |
| Melting Point: | 226 °C (dec.) |
| Boiling Point: | 483.2 °C at 760 mmHg |
| Flash Point: | 172.2 °C |
| Solubility: | freely soluble in water |
| Appearance: | Crystalline solid |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 22 |
| Safety: | 22 |
| PSA: | 49.81000 |
| LogP: | 4.66200 |
- 81281-59-67-Benzylideneaminotheophylline
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 717878-06-31-(4-fluorophenyl)-4-nitro-1H-imidazole
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
Chemistry
The Molecular Structure of Papaverine hydrochloride (CAS NO.61-25-6):
MF: C20H22ClNO4
MW: 375.85
Melting point: 226 ºC
Water Solubility: freely soluble
Stability: Stable, but may be light sensitive
Appearance: Crystalline Solid
Product Categories: Quinoline&Isoquinoline;Alkaloids;Biochemistry;Isoquinoline Alkaloids;Intermediates & Fine Chemicals;Pharmaceuticals
InChI
InChI=1/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H
Smiles
Cl.c12c(cc(OC)c(c2)OC)ccnc1Cc1cc(c(OC)cc1)OC
IUPAC Name: 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline
Uses
Papaverine hydrochloride (CAS NO.61-25-6) can be uese as Smooth muscle relaxant that found in opium. Vasodilator (cerebral).
Toxicity Data With Reference
| 1. | cyt-ham:fbr 125 mg/L | ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the National Hygiene Sciences. 96 (1978),55. | ||
| 2. | cyt-ham:lng 340 mg/L | GMCRDC Gann Monograph on Cancer Research. 27 (1981),95. | ||
| 3. | orl-wmn TDLo:300 mg/kg:CVS | CTOXAO Clinical Toxicology. 18 (1981),417. | ||
| 4. | orl-rat LD50:360 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 149 (1964),200. | ||
| 5. | ipr-rat LD50:64 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 6 (1956),454. | ||
| 6. | scu-rat LD50:368 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 6 (1956),454. | ||
| 7. | ivn-rat LD50:20 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 123 (1960),264. | ||
| 8. | idu-rat LD50:71 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 180 (1969),155. | ||
| 9. | orl-mus LD50:130 mg/kg | JOETD7 Journal of Ethnopharmacology. 6 (1982),127. | ||
| 10. | ipr-mus LD50:108 mg/kg | JMCMAR Journal of Medicinal Chemistry. 16 (1973),1063. | ||
| 11. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Poison by ingestion, intraperitoneal, intraduodenal, intravenous, and subcutaneous routes. Human systemic effects: metabolic acidosis, pulse rate increase. An experimental teratogen. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also PAPAVERINE.
Hazard Codes:
Xn
C
F
Risk Statements: 22-34-11
R22: Harmful if swallowed
R34: Causes burns
R11: Highly flammable
Safety Statements: 22-45-36/37/39-26-16
S22: Do not breathe dust
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S16: Keep away from sources of ignition
RIDADR: UN 1544 6.1/PG 3
WGK Germany: 1
RTECS: NW8575000
F: 8
HazardClass: 6.1
PackingGroup: III
Specification
Papaverine hydrochloride (CAS NO.61-25-6) is also called as 6,7-Dimethoxy-1-veratrylisoquinoline hcl ; 6,7-Dimethoxy-1-veratryl-isoquinoline hydrochloride ; 6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)-isoquinoline hydrochloride ; 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride ; 1-[(3',4'-Dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline hcl ; Papaverine hcl ; Papaverine hydrochloride ; 1-((3,4-Dimethoxyphenyl)methyl)-6,7-dimethoxy-isoquinolinhydrochloride .