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614-39-1

Basic Information
CAS No.: 614-39-1
Name: Procainamide hydrochloride
Article Data: 1
Molecular Structure:
Molecular Structure of 614-39-1 (Procainamide hydrochloride)
Formula: C13H22ClN3O
Molecular Weight: 271.79
Synonyms: Procamid;Procamide;Procan SR;Procapan;Procardyl;Pronestyl;Pronestyl hydrochloride;Spicain amide;Benzamide,4-amino-N-[2-(diethylamino)ethyl]-, monohydrochloride (9CI);Benzamide, p-amino-N-[2-(diethylamino)ethyl]-,monohydrochloride (8CI);4-Amino-N-[2-(diethylamino)ethyl]benzamidemonohydrochloride;Amidoprocaine;Amisalin;Cardiorytmin;HC 5006;Novocaineamide hydrochloride;Novocamid hydrochloride;Procainamidemonohydrochloride;
EINECS: 210-381-7
Density: 1.2027 (rough estimate)
Melting Point: 165-168 °C
Boiling Point: 421.8 °C at 760 mmHg
Flash Point: 208.9 °C
Solubility: soluble in water
Appearance: White to slightly yellow powder
Hazard Symbols: HarmfulXn
Risk Codes: 22-36/37/38
Safety: 26-36-37/39
PSA: 58.36000
LogP: 3.11450
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  • 99% up by HPLC Procainamide hydrochloride Procainamide HCL 614-39-1

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Chemistry

Molecular Formula: C13H22ClN3O
Formula Weight: 271.79
Melting point: 165-168 °C
Flash Point: 208.9 °
Boiling Point: 421.8 °C at 760 mmHg  
Water Solubility : PROCAINAMIDE HYDROCHLORIDE (614-39-1) is soluble
Vapour Pressure: 2.54E-07 mmHg at 25°C  
Sensitive : Light Sensitive/Air Sensitive
Appearance of PROCAINAMIDE HYDROCHLORIDE (614-39-1): Solid

Toxicity Data With Reference

1.   

orl-man LDLo:857 mg/kg/60D-I:BLD

   AHJOA2    American Heart Journal. 105 (1983),1035.
2.   

orl-man TDLo:200 mg/kg/4W-I:BLD

   AIMDAP    Archives of Internal Medicine. 145 (1985),700.
3.   

orl-man TDLo:2786 mg/kg/56W-I:BLD,MSK

   AJMEAZ    American Journal of Medicine. 80 (1986),999.
4.   

ivn-rat LD50:95 mg/kg

   ARZNAD    Arzneimittel-Forschung. Drug Research. 18 (1968),1127.
5.   

orl-mus LD50:1110 mg/kg

   ARZNAD    Arzneimittel-Forschung. Drug Research. 18 (1968),1127.
6.   

ipr-mus LD50:325 mg/kg

   APTOA6    Acta Pharmacologica et Toxicologica. 28 (1970),17.
7.   

scu-mus LD50:800 mg/kg

   PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 73 (1950),236.
8.   

ivn-mus LD50:94,640 µg/kg

   NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),719.
9.   

ims-mus LD50:860 mg/kg

   THERAP    Therapie. 9 (1954),332.
10.   

ivn-mus LD50:150 mg/kg

   ARZNAD    Arzneimittel-Forschung. Drug Research. 18 (1968),112

Safety Profile

Hazard Codes : Xn: Harmful
Risk Statements : 22: Harmful if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements : 26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection 
WGK Germany : 3
RTECS : CV2295000
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: agranulocytosis, thrombocytopenia, leukopenia, joint effects. Used as a local anesthetic. When heated to decomposition PROCAINAMIDE HYDROCHLORIDE (614-39-1) emits very toxic fumes of HCl and NOx.

Specification

Storage of PROCAINAMIDE HYDROCHLORIDE (614-39-1): Keep container tightly closed. Keep container dry. Keep in a cool place. Keep in a cool, well-ventilated place. Ground all equipment containing material. Combustible materials should be stored away from extreme heat and away from strong oxidizing agents.