CAS No.626-67-5,N-Methylpiperidine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	626-67-5
Name:	N-Methylpiperidine
Article Data:	204

Formula:	C₆H₁₃N
Molecular Weight:	99.1759
Synonyms:	1-Methylpiperidine;
EINECS:	210-959-9
Density:	0.844 g/cm³
Melting Point:	-50 °C
Boiling Point:	97.569 °C at 760 mmHg
Flash Point:	3.333 °C
Solubility:	Soluble in water, alcohol and ether
Appearance:	colorless clear liquid
Hazard Symbols:	C,F,T
Risk Codes:	11-34-20/22-39/23/24/25-67
Safety:	7-16-26-36/37/39-45-9-33
Transport Information:	UN 3286 3/PG 2
PSA:	3.24000
LogP:	1.04000

Synthetic route

: 110-89-4
piperidine

: 67-56-1
methanol

: 626-67-5
N-methylcyclohexylamine

Conditions

Conditions	Yield
With P(C4H9)3; ruthenium trichloride at 220℃; for 5h; Product distribution; Mechanism; also with or without other catalyst, other phosphines, other temperatures,;	100%
chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II) at 100℃; for 3h;	100%
Pt on TiO2 for 20h; Ambient temperature; Irradiation;	93.4%

: 694-55-3
N-methyl-3,4-didehydropiperidine

: 201230-82-2
carbon monoxide

: 626-67-5
N-methylcyclohexylamine

Conditions

Conditions	Yield
With hydrogen; di-μ-chlorobis(norbornadiene)dirhodium(I) In benzene at 100℃; under 60004.8 Torr; for 6h;	100%

: 2591-86-8
N-Formylpiperidine

: 626-67-5
N-methylcyclohexylamine

Conditions

Conditions	Yield
With 1,1,3,3-Tetramethyldisiloxane; [((CH3)5C5)IrCl((CH3)2NC6H3C5H4N)]; trityl tetrakis(pentafluorophenyl)borate In 1,1,2,2-tetrachloroethane at 100℃; for 6h; Inert atmosphere; Schlenk technique; Glovebox; chemoselective reaction;	99%
With phenylsilane; caesium carbonate at 25℃; for 30h; Schlenk technique;	51%
With lithium aluminium tetrahydride; diethyl ether

: 110-89-4
piperidine

: 149-73-5
trimethyl orthoformate

: 626-67-5
N-methylcyclohexylamine

Conditions

Conditions	Yield
With 3 % platinum on carbon; hydrogen; toluene-4-sulfonic acid at 120℃; under 30003 Torr; for 3h; Reagent/catalyst; Inert atmosphere; Autoclave;	99%

: 110-89-4
piperidine

: 50-00-0
formaldehyd

: 626-67-5
N-methylcyclohexylamine

Conditions

Conditions	Yield
With acetic acid at 30℃; for 2h;	98%
With diiodo(p-cymene)ruthenium(II) dimer In water at 60℃; for 2h;	95%
Stage #1: piperidine; formaldehyd With hydrogenchloride In methanol at 20℃; Stage #2: With N-methylpiperidine zinc borohydride In methanol at 20℃; for 0.1h;	89%

: 110-89-4
piperidine

: (1H-indol-3-yl)dimethylsulfonium perchlorate

A: 626-67-5
N-methylcyclohexylamine

B: 40015-10-9
3-methylthioindole

Conditions

Conditions	Yield
at 106℃; for 1h;	A n/a B 96%

...Expand

: 111-29-5
1 ,5-pentanediol

: 626-67-5
N-methylcyclohexylamine

Conditions

Conditions	Yield
With methylamine	95%

: 54105-23-6
1,1'-Dimethyl-3-(2'-piperidyl)-1,4,5,6-tetrahydropyridin

A: 626-67-5
N-methylcyclohexylamine

B: 931-20-4
1-methylpiperidin-2-one

C: 106940-68-5
1-Methyl-3-(5-methylamino-pentyliden)piperidin

Conditions

Conditions	Yield
With hydrogenchloride; sodium tetrahydroborate In ethanol for 18h;	A n/a B n/a C 88%

...Expand

: 17049-50-2
n-decyl magnesium bromide

: 13134-23-1
benzophenone N-methyl-N,N-pentane-1,5-diylhydrazonium iodide

A: 626-67-5
N-methylcyclohexylamine

B: 1013-88-3
Benzophenone imine

C: 124-18-5
decane

D: 112-95-8
icosane

E: 872-05-9
1-Decene

Conditions

Conditions	Yield
In diethyl ether Product distribution; Mechanism; Heating; other quaternary hydrazonium salts, other alkylmagnesium halides;	A 85% B 84% C 51% D 21% E 25%

...Expand

: 67-56-1
methanol

: 173978-45-5
C8H16LiN

: 626-67-5
N-methylcyclohexylamine

Conditions

Conditions	Yield
Ambient temperature;	82%

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Consensus Reports

Reported in EPA TSCA Inventory.

Standards and Recommendations

DOT Classification: 3; Label: Flammable Liquid

Specification

The N-Methylpiperidine, with the CAS registry number 626-67-5, is also known as Piperidine, 1-methyl-. It belongs to the product categories of Piperidine; Building Blocks; Heterocyclic Building Blocks; Piperidines; Alphabetical Listings; Flavors and Fragrances. Its EINECS number is 210-959-9. This chemical's molecular formula is C₆H₁₃N and molecular weight is 99.17. What's more, its systematic name is 1-Methylpiperidine. This chemical should be sealed and stored in a cool and dry place. Moreover, it should be protected from oxides. It is used as organic reagent and pharmaceutical intermediates.

Physical properties of N-Methylpiperidine are: (1)ACD/LogP: 1.207; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.85; (4)ACD/LogD (pH 7.4): -0.94; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 3.24 Å²; (13)Index of Refraction: 1.446; (14)Molar Refractivity: 31.333 cm³; (15)Molar Volume: 117.509 cm³; (16)Polarizability: 12.421×10^-24cm³; (17)Surface Tension: 26.7 dyne/cm; (18)Density: 0.844 g/cm³; (19)Flash Point: 3.333 °C; (20)Enthalpy of Vaporization: 33.705 kJ/mol; (21)Boiling Point: 97.569 °C at 760 mmHg; (22)Vapour Pressure: 41.5 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical is highly flammable, so you should keep it away from sources of ignition - No smoking. It can cause burns. You should keep the container tightly closed and keep it in a well-ventilated place. It is toxic as it has a danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed. This substance is harmful by inhalation and if swallowed. Its vapors may cause drowsiness and dizziness. You must take precautionary measures against static discharges. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective gloves and eye/face protection. In case of accident or if you feel unwell, you should seek medical advice immediately (show label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: N1(C)CCCCC1
(2)Std. InChI: InChI=1S/C6H13N/c1-7-5-3-2-4-6-7/h2-6H2,1H3
(3)Std. InChIKey: PAMIQIKDUOTOBW-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	400mg/kg (400mg/kg)		Bulletin of Experimental Biology and Medicine Vol. 86, Pg. 1325, 1978.
rabbit	LDLo	subcutaneous	400mg/kg (400mg/kg)		Berichte der Deutschen Chemischen Gesellschaft. Vol. 34, Pg. 2408, 1901.
rat	LDLo	oral	25mg/kg (25mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	National Technical Information Service. Vol. OTS0554064,