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CAS No.: | 6271-78-9 |
---|---|
Name: | 6-Chloronicotinamide |
Article Data: | 13 |
Molecular Structure: | |
Formula: | C6H5ClN2O |
Molecular Weight: | 156.572 |
Synonyms: | Nicotinamide,6-chloro- (6CI,7CI,8CI);2-Chloro-5-carbamoylpyridine;6-Chloro-3-pyridinecarboxamide;6-Chloronicotinamide;NSC 37821; |
EINECS: | 228-456-8 |
Density: | 1.381 g/cm3 |
Melting Point: | 210-212 °C(lit.) |
Boiling Point: | 331 °C at 760 mmHg |
Flash Point: | 154 °C |
Hazard Symbols: | Xn |
Risk Codes: | 36/37/38-20/21/22 |
Safety: | 26-36/37/39-22 |
PSA: | 55.98000 |
LogP: | 1.53420 |
6-chloronicotinonitrile
6-chloro-3-pyridinecarboxamide
Conditions | Yield |
---|---|
With manganese(IV) oxide; water In isopropyl alcohol at 50℃; under 5171.62 Torr; for 0.166667h; | 99% |
(6-chloro-pyridin-3-yl)-acetonitrile
6-chloro-3-pyridinecarboxamide
Conditions | Yield |
---|---|
With ammonium hydroxide; 5 wt% ruthenium/carbon; oxygen In tetrahydrofuran at 30℃; for 20h; | 86% |
6-chloronicotinonitrile
methyl magnesium iodide
diethyl ether
A
6-chloro-3-pyridinecarboxamide
B
3-acetyl-6-chloropyridine
Conditions | Yield |
---|---|
With phosphorus pentachloride; trichlorophosphate at 120℃; Behandeln des entstandenen 6-Chlor-nicotinsaeure-chlorid mit Benzol und Ammoniak; | |
With trichlorophosphate Behandeln des Reaktionsprodukts in Aceton mit wss. NH3; |
Conditions | Yield |
---|---|
With oxalyl dichloride; benzene Behandeln des Reaktionsgemisches mit wss. NH3; |
Conditions | Yield |
---|---|
With ammonium hydroxide; phosphorus pentachloride; trichlorophosphate |
6-Chloronicotinoyl chloride
6-chloro-3-pyridinecarboxamide
Conditions | Yield |
---|---|
With ammonia In toluene at 20℃; for 8h; | 7.15 g |
With ammonia In diethyl ether | 9 g |
With ammonia In water at 0℃; for 0.5h; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: SOCl2 / 4 h / Heating 2: 9 g / NH3 gas / diethyl ether View Scheme | |
Multi-step reaction with 2 steps 1: SOCl2 / 15 h / Heating 2: 7.15 g / NH3*H2O / toluene / 8 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 25 °C 2: ammonia / water / 0.5 h / 0 °C View Scheme |
2-chloro-5-methylpyridine
6-chloro-3-pyridinecarboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 60.1 percent / KMnO4 / H2O / 5 h / Heating 2: SOCl2 / 15 h / Heating 3: 7.15 g / NH3*H2O / toluene / 8 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: bromine; aqueous sodium nitrite solution; aqueous hydrobromic acid 2: aqueous KMnO4 3: oxalyl chloride; benzene / Behandeln des Reaktionsgemisches mit wss. NH3 View Scheme |
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