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62965-35-9

Basic Information
CAS No.: 62965-35-9
Name: N-Boc-L-tert-Leucine
Article Data: 44
Cas Database
Molecular Structure:
Molecular Structure of 62965-35-9 (N-Boc-L-tert-Leucine)
Formula: C11H21NO4
Molecular Weight: 231.292
Synonyms: Boc-Tle-OH;(2S)-2-(tert-Butoxycarbonylamino)-3,3-dimethylbutanoicacid;(S)-2-(((tert-Butoxy)carbonyl)amino)-3,3-dimethylbutanoic acid;(S)-2-tert-Butoxycarbonylamino-3,3-dimethylbutyric acid;BOC-L-tert-leucine;
EINECS: 613-118-8
Density: 1.063 g/cm3
Melting Point: 118-121 °C
Boiling Point: 350 °C at 760 mmHg
Flash Point: 165.5 °C
Appearance: white crystalline powder
Safety: 24/25
PSA: 75.63000
LogP: 2.40130
Synthetic route
20859-02-3

L-tert-Leucine

24424-99-5

di-tert-butyl dicarbonate

62965-35-9

N-tert-butyloxycarbonyl-L-tert-leucine

Conditions
ConditionsYield
With triethylamine In methanol at 0 - 5℃;100%
With triethylamine In methanol at 0 - 5℃;100%
With sodium hydroxide In 1,4-dioxane at 20℃; for 12h;100%
NaHSO4·H2O

NaHSO4·H2O

20859-02-3

L-tert-Leucine

24424-99-5

di-tert-butyl dicarbonate

62965-35-9

N-tert-butyloxycarbonyl-L-tert-leucine

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water99%
With triethylamine In 1,4-dioxane; water99%

D,L-N-Boc-t-leucine methyl ester

A

62965-35-9

N-tert-butyloxycarbonyl-L-tert-leucine

B

153960-35-1

N-Boc-D-tert-leucine methyl ester

Conditions
ConditionsYield
With Bacillus licheniformis In water at 35℃; for 23h; pH=7.8;A 93%
B n/a
With Bacillus licheniformis In water at 35℃; for 18h; pH=7.8;A n/a
B 82%
153645-26-2

N-Boc-L-tert-leucinol

62965-35-9

N-tert-butyloxycarbonyl-L-tert-leucine

Conditions
ConditionsYield
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; Isopropyl acetate; sodium hydrogencarbonate; sodium bromide at 0 - 25℃;73%

C14H21F6NO4

A

62965-35-9

N-tert-butyloxycarbonyl-L-tert-leucine

B

124655-17-0

(R)-2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoic acid

Conditions
ConditionsYield
With C28H30N3O2(1+)*Br(1-); sodium hydroxide In chloroform at 0℃; for 24h;A 52%
B n/a
1070-19-5

N-(tert-butyloxycarbonyl) azide

20859-02-3

L-tert-Leucine

62965-35-9

N-tert-butyloxycarbonyl-L-tert-leucine

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane
20859-02-3

L-tert-Leucine

58632-95-4

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

62965-35-9

N-tert-butyloxycarbonyl-L-tert-leucine

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water for 4h; Ambient temperature;
335628-21-2

(4S,5R)-3-tert-butoxycarbonyl-4-tert-butyl-5-methoxy-2-oxazolidinone

62965-35-9

N-tert-butyloxycarbonyl-L-tert-leucine

Conditions
ConditionsYield
With potassium hydroxide; potassium permanganate In water; tert-butyl alcohol

D,L-N-Boc-t-leucine methyl ester

A

62965-35-9

N-tert-butyloxycarbonyl-L-tert-leucine

B

124655-17-0

(R)-2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoic acid

C

153960-35-1

N-Boc-D-tert-leucine methyl ester

Conditions
ConditionsYield
With subtilisin In water at 35℃; for 18h; pH=7.5;

D,L-N-Boc-t-leucine methyl ester

A

62965-35-9

N-tert-butyloxycarbonyl-L-tert-leucine

B

153960-35-1

N-Boc-D-tert-leucine methyl ester

C

176504-88-4

2-tert-butoxycarbonylamino-3,3-dimethylbutyric acid methyl ester

Conditions
ConditionsYield
With subtilisin In water at 35℃; for 15h; pH=7.5;
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Chemistry

Molecular structure of N-Boc-L-tert-Leucine (CAS NO.62965-35-9) is:

Product Name: N-Boc-L-tert-Leucine
CAS Registry Number: 62965-35-9
Empirical Formula: C11H21NO4
Molecular Weight: 231.2887
Melting Point: 118-121 °C
Surface Tension: 35.7 dyne/cm
Density: 1.063 g/cm3
Flash Point: 165.5 °C
Enthalpy of Vaporization: 65.33 kJ/mol
Boiling Point: 350 °C at 760 mmHg
Vapour Pressure: 7.8E-06 mmHg at 25°C
Product Categories: Amino Acids;Leucine [Leu, L];Amino Acids & Deriv.;Chiral Chemicals;Peptide

Safety Profile

Safety Statements: 24/25 
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
HazardClass: IRRITANT

Specification

 N-Boc-L-tert-Leucine , its cas register number is 62965-35-9. It also can be called N-(tert-Butoxycarbonyl)-L-tert-leucine ; (S)-N-Boc-2-Amino-3,3-dimethylbutyric acid .It is a white crystalline powder.

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