CAS No.632-22-4,1,1,3,3-Tetramethylurea Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	632-22-4
Name:	1,1,3,3-Tetramethylurea
Article Data:	66

Formula:	C₅H₁₂N₂O
Molecular Weight:	116.163
Synonyms:	Urea,1,1,3,3-tetramethyl- (6CI);Urea, tetramethyl- (8CI,9CI);NSC 91488;TMU;Temur;Tetramethylcarbamide;
EINECS:	211-173-9
Density:	0.9879 g/cm³
Melting Point:	-1 °C(lit.)
Boiling Point:	175.2 °C at 760 mmHg
Flash Point:	53.9 °C
Solubility:	miscible with water
Appearance:	Clear colorless to pale yellow liquid
Hazard Symbols:	Xn
Risk Codes:	22
Safety:	53-45
PSA:	23.55000
LogP:	0.22960

Synthetic route

: 32315-10-9
bis(trichloromethyl) carbonate

: 124-40-3
dimethyl amine

: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
In dichloromethane; water at 15 - 20℃; Large scale;	92%

: 201230-82-2
carbon monoxide

: 506-59-2
N,N-dimethylammonium chloride

: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With 2C7H9N4Au(1+)Cu(1+)*2I(1-); sodium carbonate In toluene at 60℃; Autoclave;	86%

: 2782-91-4
1,1,3,3-tetramethyl-2-thiourea

: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With hydrogenchloride; N-nitrosopiperidine; potassium iodide In dichloromethane; water at 22℃; for 48h;	85%
With manganese(IV) oxide In chloroform Ambient temperature;	79%
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane for 5h; Ambient temperature;	75%

: 138767-93-8
C16H27N3O4Si

: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
In chloroform-d1 at 90℃; for 20h;	81%

: 78581-29-0
Bis(N,N,N',N'-tetramethylformamidinium)ether-bis(trifluormethansulfonat)

: 109-77-3
malononitrile

A: 31774-36-4
(bis-dimethylamino-methylene)-malononitrile

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With dimethylaminomethyl-polystyrene In acetonitrile at 25℃; for 24h;	A 70% B n/a

...Expand

: 18424-76-5
dimethyl malonate sodium salt

: 78581-29-0
Bis(N,N,N',N'-tetramethylformamidinium)ether-bis(trifluormethansulfonat)

A: 31774-43-3
malonsaeure-dimethylester

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
In acetonitrile at 25℃; for 0.25h;	A 55% B n/a

...Expand

: 555-21-5
4-Nitrophenylacetonitrile

: 78581-29-0
Bis(N,N,N',N'-tetramethylformamidinium)ether-bis(trifluormethansulfonat)

A: 22703-65-7
α--4-nitrophenylacetonitrile

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With dimethylaminomethyl-polystyrene In acetonitrile at 81℃; for 20h;	A 52% B n/a

...Expand

: 78581-29-0
Bis(N,N,N',N'-tetramethylformamidinium)ether-bis(trifluormethansulfonat)

: 105-56-6
ethyl 2-cyanoacetate

A: 72834-60-7
2-Cyan-3,3-bis-(dimethylamino)-acrylsaeure-ethylester

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With dimethylaminomethyl-polystyrene In acetonitrile at 81℃; for 20h;	A 51% B n/a

...Expand

: 63442-64-8
bis(dimethylamino)malononitrile

: 141-52-6
sodium ethanolate

A: 67751-11-5
N,N,N',N'-Tetramethylharnstoff-diethylacetal

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
In acetonitrile for 12h;	A 42% B 14 % Spectr.

...Expand

: 78581-29-0
Bis(N,N,N',N'-tetramethylformamidinium)ether-bis(trifluormethansulfonat)

: 5353-66-2
diphenylphosphorylazide

Et3N: Et3N

A: 97513-13-8
<2-<2,2-Bis(dimethylamino)-1-(diphenylphosphoryl)vinyl>-2H-tetrazol-5-yl>diphenylphosphanoxid

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
In acetonitrile -20 deg C to r.t. 30 min;	A 42% B 39%

...Expand

Raw Materials

80-70-6

555-21-5

75-44-5

Downstream Products

141-53-7

Total:124 Page 1 of 4 1 2 3 4 Next>>

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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

The 1,1,3,3-Tetramethylurea, also known as N,N,N',N'-Tetramethylurea, is the organic compound with the formula C₅H₁₂N₂O. This chemical belongs to the product category of Miscellaneous. Its EINECS registry number is 211-173-9. With the CAS registry number 632-22-4, its IUPAC name is called 1,1,3,3-Tetramethylurea.

Physical properties of 1,1,3,3-Tetramethylurea: (1)ACD/LogP: 0.19; (2)ACD/LogD (pH 5.5): 0.19; (3)ACD/LogD (pH 7.4): 0.19; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 30.22; (7)ACD/KOC (pH 7.4): 30.22; (8)#H bond acceptors: 3; (9)Index of Refraction: 1.445; (10)Molar Refractivity: 32.68 cm³; (11)Molar Volume: 122.6 cm³; (12)Surface Tension: 30.1 dyne/cm; (13)Density: 0.946 g/cm³; (14)Flash Point: 53.9 °C; (15)Enthalpy of Vaporization: 41.15 kJ/mol; (16)Boiling Point: 175.2 °C at 760 mmHg; (17)Vapour Pressure: 1.16 mmHg at 25°C.

Preparation of 1,1,3,3-Tetramethylurea: this chemical can be prepared by diphenyl carbonate and dimethylamine. The reaction mixture is heated at 200 °C for 4 h and is cooled down. The reactant is stired after addition of NaOH. Then it will be purified by diethyl ether. Hence, decompress fractionation are chosen to separate the product. Finally, you will obtained tetramethylurea.

(C₆H₅)₂CO+(CH3)₂NH → C₆H₅OH+C₆H₅OCON(CH₃)₂C₆H₅OCON(CH₃)₂ → C₆H₅OH+(CH₃)₂NCON(CH₃)₂

Uses of 1,1,3,3-Tetramethylurea: because of its low permittivity, this chemical is appropriate for isomerization and alkylation hydrocyanation of base catalysis. It can also be used as other condensation reaction solvent. In addition, it can be used as acetylene and polyacrylonitrile solvents.

When you are using this chemical, please be cautious about it. This chemical may cause damage to health. It is harmful if swallowed. You must avoid exposure - obtain special instructions before use. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CN(C)C(=O)N(C)C
(2)InChI: InChI=1S/C5H12N2O/c1-6(2)5(8)7(3)4/h1-4H3
(3)InChIKey: AVQQQNCBBIEMEU-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
monkey	LDLo	intravenous	750mg/kg (750mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 1600, Pg. 333, 1966.
mouse	LD50	intravenous	2230mg/kg (2230mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 160, Pg. 333, 1966.
mouse	LD50	oral	2920mg/kg (2920mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 160, Pg. 333, 1966.
mouse	LDLo	intraperitoneal	2900mg/kg (2900mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Journal of Pharmacology and Experimental Therapeutics. Vol. 54, Pg. 188, 1935.
rabbit	LD50	skin	3160mg/kg (3160mg/kg)	BEHAVIORAL: TREMOR	National Technical Information Service. Vol. OTS0559251,
rat	LCLo	inhalation	312ppm/4H (312ppm)	BEHAVIORAL: ATAXIA	National Technical Information Service. Vol. OTS0559251,
rat	LD50	intravenous	1100mg/kg (1100mg/kg)		Angewandte Chemie, International Edition in English. Vol. 3, Pg. 260, 1964.
rat	LD50	oral	794mg/kg (794mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	National Technical Information Service. Vol. OTS0559251,
rat	LD50	unreported	1400mg/kg (1400mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1073, 1969.