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CAS No.: | 634-47-9 |
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Name: | 2-CHLOROLEPIDINE |
Article Data: | 21 |
Molecular Structure: | |
Formula: | C10H8ClN |
Molecular Weight: | 177.633 |
Synonyms: | Lepidine,2-chloro- (6CI,7CI,8CI);2-Chloro-4-methylquinoline;2-Chlorolepidine;NSC96476; |
EINECS: | 211-209-3 |
Density: | 1.225 g/cm3 |
Melting Point: | 55-58 °C(lit.) |
Boiling Point: | 296 °C at 760 mmHg |
Flash Point: | 158.2 °C |
Appearance: | white to light yellow crystal powder |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-37/39 |
PSA: | 12.89000 |
LogP: | 3.19660 |
Conditions | Yield |
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With trichlorophosphate In dichloromethane; N,N-dimethyl-formamide at 0 - 25℃; Inert atmosphere; regioselective reaction; | 81% |
2-chloro-4-methylquinoline
Conditions | Yield |
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With lithium chloride In 1,4-dioxane at 80℃; for 72h; Inert atmosphere; Sealed tube; regioselective reaction; | 32% |
Conditions | Yield |
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With phosphorus pentachloride; trichlorophosphate for 24h; Chlorination; Heating; | 96% |
With trichlorophosphate for 10h; Heating; | 82% |
With phosphorus pentachloride; trichlorophosphate |
2-Chloro-4-methylquinoline 1-oxide
2-chloro-4-methylquinoline
Conditions | Yield |
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With tris(bipyridine)ruthenium(II) dichloride hexahydrate; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate In acetonitrile at 20℃; for 0.0833333h; Inert atmosphere; Irradiation; chemoselective reaction; | 82% |
Conditions | Yield |
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With phosphorus pentachloride; trichlorophosphate at 135 - 140℃; | |
With phosphorus pentachloride; benzoyl chloride at 250℃; | |
With ((1,3,5-triazine-2,4,6-triyl)tris(oxy))tris(triphenylphosphonium) chloride In neat (no solvent) at 140 - 150℃; for 2h; | |
With trichlorophosphate at 120℃; for 2h; |
2-chloro-4-methylquinoline
Conditions | Yield |
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With trichlorophosphate at 80 - 85℃; |
Conditions | Yield |
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With zinc dibromide In tetrahydrofuran |
Conditions | Yield |
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Multi-step reaction with 2 steps 1: sulfuric acid / 1 h / 100 °C 2: trichlorophosphate / 2 h / 120 °C View Scheme | |
Multi-step reaction with 2 steps 1: Polyphosphoric acid / 130 - 140 °C 2: trichlorophosphate; pyridine / 80 - 90 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 0.07 h / microwave irradiation 1.2: H2SO4 / 0.08 h / microwave irradiation 2.1: 82 percent / POCl3 / 10 h / Heating View Scheme |
Conditions | Yield |
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Multi-step reaction with 3 steps 1: 3 h / 185 °C 2: sulfuric acid / 1 h / 100 °C 3: trichlorophosphate / 2 h / 120 °C View Scheme |
Molecular Structure:
Molecular Formula: C10H8ClN
Molecular Weight: 177.6302
IUPAC Name: 2-Chloro-4-methylquinoline
Synonyms of Quinoline,2-chloro-4-methyl- (CAS NO.634-47-9): 2-Chloro-4-methylquinoline ; 2-Chlorolepidine ; EINECS 211-209-3 ; NSC 96476 ; Lepidine, 2-chloro- (8CI) ; Quinoline, 2-chloro-4-methyl- (9CI)
CAS NO: 634-47-9
Classification Code: Quinoline&Isoquinoline ; Alkylquinolines ; Haloquinolines ; Quinolines
Melting point: 55-58 °C
Index of Refraction: 1.634
Molar Refractivity: 51.9 cm3
Molar Volume: 144.9 cm3
Surface Tension: 46.5 dyne/cm
Density: 1.225 g/cm3
Flash Point: 158.2 °C
Enthalpy of Vaporization: 51.43 kJ/mol
Boiling Point: 296 °C at 760 mmHg
Vapour Pressure: 0.0026 mmHg at 25°C
Quinoline,2-chloro-4-methyl- (CAS NO.634-47-9) is used in organic synthesis.
Hazard Codes of Quinoline,2-chloro-4-methyl- (CAS NO.634-47-9): Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39: Wear suitable gloves and eye/face protection.
S36: Wear suitable protective clothing.
WGK Germany: 3