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| CAS No.: | 637-58-1 |
|---|---|
| Name: | Pramoxine hydrochloride |
| Article Data: | 1 |
| Molecular Structure: | |
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| Formula: | C17H28ClNO3 |
| Molecular Weight: | 329.867 |
| Synonyms: | Morpholine,4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride (9CI);Morpholine, 4-[3-(p-butoxyphenoxy)propyl]-,hydrochloride (7CI,8CI);Pramoxine hydrochloride (6CI);4-[3-(p-Butoxyphenoxy)propyl]morpholine hydrochloride;Pramocainehydrochloride;Proctofoam;Tronolaine;Tronothan;Tronothane;Tronothanehydrochloride; |
| EINECS: | 211-293-1 |
| Melting Point: | 181-183oC |
| Boiling Point: | 427 °C at 760 mmHg |
| Flash Point: | 123.5 °C |
| Appearance: | White or off white crystalline powder |
| Hazard Symbols: |
 Xi,  Xn
|
| Risk Codes: | 22-36/37/38 |
| Safety: | 26-36 |
| PSA: | 30.93000 |
| LogP: | 3.70650 |
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pramoxine hydrochloride
| Conditions | Yield |
|---|---|
| With sodium hydride In tetrahydrofuran at 20℃; for 5h; Reflux; | 82.61% |
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Specification
The Pramoxine hydrochloride, with the CAS registry number 637-58-1,is also known as 4-n-Butoxyphenyl gamma-morpholinopropyl ether hydrochloride. It belongs to the product categories of Organic matters.Its EINECS number is 211-293-1. This chemical's molecular formula is C17H27NO3.HCl and molecular weight is 329.87. What's more,Its systematic name is Pramocaine hydrochloride.The Pramoxine hydrochloride is harmful if swallowed and irritating to eyes, respiratory system and skin.When you use it ,wear suitable protective clothing .In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Physical properties about Pramoxine hydrochloride are:
(1)ACD/LogP: 3.477; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.52; (4)ACD/LogD (pH 7.4): 3.13; (5)ACD/BCF (pH 5.5): 2.85; (6)ACD/BCF (pH 7.4): 116.77; (7)ACD/KOC (pH 5.5): 20.48; (8)ACD/KOC (pH 7.4): 838.17; (9)#H bond acceptors: 4; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 9; (12)Flash Point: 123.5 °C; (13)Enthalpy of Vaporization: 68.19 kJ/mol ; (14)Boiling Point: 427 °C at 760 mmHg; (15)Vapour Pressure: 1.7E-07 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES:Cl.O(c2ccc(OCCCN1CCOCC1)cc2)CCCC;
(2)Std. InChI:InChI=1S/C17H27NO3.ClH/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18;/h5-8H,2-4,9-15H2,1H3;1H;
(3)Std. InChIKey:SYCBXBCPLUFJID-UHFFFAOYSA-N.
The toxicity data of Pramoxine hydrochloride are as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LDLo | intravenous | 109mg/kg (109mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: CARDIAC OUTPUT LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Anesthesie, Analgesie, Reanimation. Vol. 14, Pg. 225, 1957. |
| mouse | LD50 | intraperitoneal | 460mg/kg (460mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969. | |
| mouse | LD50 | intravenous | 79500ug/kg (79.5mg/kg) | Toxicology and Applied Pharmacology. Vol. 1, Pg. 454, 1959. | |
| mouse | LD50 | oral | 1050mg/kg (1050mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969. | |
| mouse | LD50 | subcutaneous | 1470mg/kg (1470mg/kg) | CARDIAC: CARDIAC OUTPUT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Anesthesie, Analgesie, Reanimation. Vol. 14, Pg. 225, 1957. |
| rabbit | LD50 | intravenous | 39mg/kg (39mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969. |