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63717-27-1

Basic Information
CAS No.: 63717-27-1
Name: Amifostine hydrate
Molecular Structure:
Molecular Structure of 63717-27-1 (Amifostine hydrate)
Formula: C5H15N2O3PS.H2O
Molecular Weight: 232.23800
Synonyms: Amifostine hydrate;Amifostinum;Amifostina;amifostine monohydrate;
Melting Point: 160-161° (dec)
Boiling Point: 441.7oC at 760 mmHg
Flash Point: 220.9oC
PSA: 139.92000
LogP: 0.77760
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  • 2-(3-aminopropylamino)ethylsulfanylphosphonic acid,hydrate

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    2-(3-aminopropylamino)ethylsulfanylphosphonic acid,hydrate

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Chemistry

IUPAC Name: 2-(3-Aminopropylamino)ethylsulfanylphosphonic acid hydrate
The molecular formula of Amifostine hydrate (CAS NO.63717-27-1) is C5H17N2O4PS.

                            
The molecular weight of Amifostine hydrate (CAS NO.63717-27-1) is 232.24.
Synonyms of Amifostine hydrate (CAS NO.63717-27-1): Ethanethiol, 2-((3-aminopropyl)amino)-, dihydrogen phosphate (ester) hydrate ; Phosphorothioic acid, S-(2-((3-aminopropyl)amino)ethyl) ester, hydrate
Enthalpy of Vaporization: 76.64 kJ/mol
Flash Point: 220.9 °C   
Boiling Point: 441.7 °C

Uses

 Amifostine hydrate (CAS NO.63717-27-1) is used as pharmaceutical intermediate.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 700mg/kg (700mg/kg)   Journal of Medicinal Chemistry. Vol. 12, Pg. 236, 1969.
mouse LD50 unreported 375mg/kg (375mg/kg)   Journal of Medicinal Chemistry. Vol. 9, Pg. 911, 1966.

Safety Profile

Poison by unspecified route. Moderately toxic by intraperitoneal route. When heated to decomposition it emits very toxic fumes of NOx, POx, and SOx. See also ESTERS.