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6381-92-6

Basic Information
CAS No.: 6381-92-6
Name: Disodium edetate dihydrate
Molecular Structure:
Molecular Structure of 6381-92-6 (Disodium edetate dihydrate)
Formula: C10H14N2Na2O8.2(H2O)
Molecular Weight: 372.23
Synonyms: Aceticacid, (ethylenedinitrilo)tetra-, disodium salt, dihydrate (8CI);Glycine,N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, disodium salt, dihydrate (9CI);Disodium EDTA dihydrate;Disodium dihydrogen ethylenediaminetetraacetatedihydrate;Disodium ethylenediaminetetraacetatedihydrate;Ethylenediaminetetraacetic acid disodium salt dihydrate;Ethylenediaminetetraacetic disodium;Edta disodium salt dihydrate;
EINECS: 205-358-3
Density: 1.01 g/mL at 25 °C
Melting Point: 250 °C (dec.)(lit.)
Boiling Point: 614.2 °C at 760 mmHg
Flash Point: 325.2 °C
Solubility: soluble except alcohol
Appearance: White crystalline powder
Hazard Symbols: IrritantXi,HarmfulXn
Risk Codes: 36-52/53-36/38-36/37/38-22
Safety: 26-61-37/39-36/37/39-36
PSA: 179.80000
LogP: -4.86920
Synthetic route

thorium(IV) nitrate pentahydrate

6381-92-6

edetate disodium dihydrate

Th(ethylenediaminetetraacetate)(H2O)*2H2O

Conditions
ConditionsYield
In water High Pressure; Th(NO3)4*5H2O, Na-salt, H2O placed in vessed, heated at 180°C for5 d; elem. anal.;45%

potassium hexachloropalatinate(IV)

6381-92-6

edetate disodium dihydrate

A

82728-71-0

Pt((HO2CCH2)2NC2H4N(CH2CO2H)2)Cl4

Pt((HO2CCH2)(O2CCH2)NC2H4N(CH2CO2)(CH2CO2H))Cl2*H2O

Conditions
ConditionsYield
In water byproducts: EDTA; solid ligand salt added to suspn. of Pt-complex (molar ratio 1.08:1) inwater, stirred until dissolution, heated with stirring to 80°C on steam bath for 1.5 h; filtered from hot soln., solid washed with hot water and acetone, driedunder vac. (Pt(EDTAH2)Cl2*H2O, filtrate evapd. to dryness in vac. desiccator, extd. with acetone, solvent removed under reduced pressure (Pt(EDTAH4)Cl4); elem. anal.;A n/a
B 43%
188416-28-6

1-(4-chloro-5-fluoropyrimidin-6-yl)bromoethane

6381-92-6

edetate disodium dihydrate

86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

(2R,3R/2S,3S)-3-(4-Chloro-5-fluoropyrimidin-6-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; iodine In tetrahydrofuran; water; acetic acid; ethyl acetate; isopropyl alcohol
6381-92-6

edetate disodium dihydrate

10108-64-2

cadmium(II) chloride

36528-30-0

Ethylendiamin-tetracetatocadmium(II)-saeure

Conditions
ConditionsYield
In water byproducts: H2O; reaction enthalpy was measured by a new method based on a laser deflection heat-sensor;
14404-41-2

tetrakis(acetato)dichromium(II) dihydrate

6381-92-6

edetate disodium dihydrate

Cr(ethylenediamminetetraacetate)(2-)

Conditions
ConditionsYield
With potassium hydroxide In water; N,N-dimethyl-formamide Na-salt, KOH, Cr-complex in H2O-DMF were reacted at pH 5.5 under Ar at room temp.;

manganese(II) sulfate

6381-92-6

edetate disodium dihydrate

manganese(III) ethylenediaminetetraacetate

Conditions
ConditionsYield
With lead dioxide In water; acetic acid
With PbO2 In water; acetic acid

gallium(III) nitrate

10213-10-2

sodium tungstate (VI) dihydrate

6381-92-6

edetate disodium dihydrate

Na10GaW9O34H*12H2O

Conditions
ConditionsYield
With sodium hydroxide; nitric acid In water Na2EDTA was added to a soln. of Ga(NO3)3, adjusted to pH 8.5 with NaOH,heated, cooled, mixed with a soln. of the tungstate, adjusted to pH 8.4-8.6 with HNO3, addn. of ethanol, reacting for 0.5 h; oil was solidified in a refrigerator at 2°C, recrystd. from water;

sodium hexacyanoferrate(II)

6381-92-6

edetate disodium dihydrate

6Na(1+)*Fe(2+)*4CN(1-)*[N(CH2COO)2CH2]2(4-)*H2O = Na6[Fe(CN)4][N(CH2COO)2CH2]2*H2O

Conditions
ConditionsYield
byproducts: HCN; equimolar mixtures, heated to 80°C; sepd. by concentration of soln. on a water bath, filtered off, washed (50% EtOH and pure EtOH), dried in air, elem. anal.;

potassium hexachloropalatinate(IV)

6381-92-6

edetate disodium dihydrate

Pt((HO2CCH2)(O2CCH2)NC2H4N(CH2CO2)(CH2CO2H))Cl2*H2O

Pt((HO2CCH2)(O2CCH2)NC2H4N(CH2CO2)(CH2CO2H))Cl2*2H2O

Conditions
ConditionsYield
In water byproducts: EDTA; solid ligand salt added to suspn. of Pt-complex (molar ratio 1.08:1) inwater, stirred until dissolution, heated with stirring to 80°C on steam bath, prolonged heated at 40°C;

potassium hexachloropalatinate(IV)

6381-92-6

edetate disodium dihydrate

Pt((HO2CCH2)(O2CCH2)NC2H4N(CH2CO2)(CH2CO2H))Cl2*2H2O

Conditions
ConditionsYield
In water byproducts: EDTA; solid ligand salt added to suspn. of Pt-complex (molar ratio 1.08:1) inwater, stirred until dissolution, heated with stirring to 80°C on steam bath, heated at 40°C on hot plate for 30 min; filtered warm, washed with ice cold water and acetone, dried under vac.; elem. anal.;
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    Product name Ethylene Diamine Tetraacetic Acid Disodium Salt CAS NO. 6381-92-6 Molecular Formula C10H14N2O8Na2•2H2O Molecular weight 372.24 Appearance White crystalline powder

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Chemistry

Molecular Structure of Edta disodium salt dihydrate (CAS NO.6381-92-6): 
 
IUPAC Name: disodium 2-[2-[bis(carboxymethyl)amino]ethyl-(2-oxido-2-oxoethyl)amino]acetate dihydrate
Molecular Formula: C10H18N2Na2O10
Molecular Weight: 372.236860 g/mol
H bond acceptors: 10
H bond donors: 4
Freely Rotating Bonds: 11
Polar Surface Area: 133.68 Å2
Appearance: crystalline
Melting Point: 250 °C (dec.)(lit.)
Boiling Point: 614.2 °C at 760 mmHg
Density: 1.01 g/mL at 25 °C
Flash Point: 325.2 °C
Storage temp: 2-8°C
solubility: 3 M NaOH: 100 mg/mL
Water Solubility: Soluble
Insolubility: alcohol
EINECS: 205-358-3
BRN: 3900609
Categories of Edta disodium salt dihydrate (CAS NO.6381-92-6): Analytical Chemistry; Chelating Reagents; Complexones; EDTA Analogs; Organic Chemicals
Synonyms of Edta disodium salt dihydrate (CAS NO.6381-92-6): aceticacid, (ethylenedinitrilo)tetra, disodiumsalt, dihydrate ; disodiumedtadihydrate ; ethylenediaminetetraaceticacidsodiumsaltdihydrate(disodiumedta ; ethylenediaminetetraaceticacidsodiumsaltdihydrate(disodiumedtadihydrate) ; glycine,n,n’-1,2-ethanediylbis(n-(carboxymethyl)-,disodiumsalt,dihydrate ; Glycine,N,N’-1,2-ethanediylbis[N-(carboxymethyl)-,disodiumsalt,dihydrate ; 1,2-Diaminoethane-n,n,n',n'-tetra-acetic acid ; edta titrant

Safety Profile

Safety Information of Edta disodium salt dihydrate (CAS NO.6381-92-6):
Hazard Codes: IrritantXi,HarmfulXn
Risk Statements: 36-52/53-36/38-36/37/38-22
36:Irritating to the eyes
52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment 
36/38:Irritating to eyes and skin 
36/37/38:Irritating to eyes, respiratory system and skin 
22:Harmful if swallowed 
Safety Statements: 26-61-37/39-36/37/39-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
61:Avoid release to the environment. Refer to special instructions safety data sheet 
37/39:Wear suitable gloves and eye/face protection
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
36:Wear suitable protective clothing  
WGK Germany: 2
RTECS: AH4025000
F: 3
HS Code: 29224995

Specification

 Chemical Properties of Edta disodium salt dihydrate (CAS NO.6381-92-6) is a white crystalline powder, it is soluble in water and insoluble in alcohol. Edta disodium(CAS NO.6381-92-6) is a chelating agent which can be used in the field of pharmaceuticals industry; Edta disodium salt dihydrate (CAS NO.6381-92-6) is also used as a complexing agent, preservative and processing material. There are many ways in Edta disodium salt dihydrate (CAS NO.6381-92-6)  production, it can not only be dissolved EDTA pH, but also by EDTA and sodium hydroxide reaction through dehydration, filtration, medium and derived, in addition to sodium cyanide method.

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