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63968-64-9

Basic Information
CAS No.: 63968-64-9
Name: Artemisinin
Molecular Structure:
Molecular Structure of 63968-64-9 (Artemisinin)
Formula: C15H22O5
Molecular Weight: 282.33
Synonyms: (+)-Arteannuin;Qinghaosu;[3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-one;
EINECS: 1806241-263-5
Density: 1.24 g/cm3
Melting Point: 156-157 oC
Boiling Point: 389.9oC at 760 mmHg
Flash Point: 172oC
Solubility:
Appearance: Crystalline Solid
Hazard Symbols:
Risk Codes:
Safety: 22-24/25
Transport Information:
PSA: 53.99000
LogP: 2.39490
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  • Casno:

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    high purity Artemisinin CAS NO.63968-64-9

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  • Artemisinin

  • Casno:

    63968-64-9

    Artemisinin

    Min.Order: 500 Milligram

    FOB Price:  USD $ 0.0-0.0/Milligram

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  • Artemisinin

  • Casno:

    63968-64-9

    Artemisinin

    Min.Order: 1 Gram

    FOB Price:  USD $ 100.0-100.0/Gram

    Artemisinin Basic information Product Name: Artemisinin Synonyms: [3r-(3r,5as,6s,8as,9r,10r,12s,12ar**)]-decahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin-10-one;A

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Chemistry

Molecular Structure: 
Molecular Formula: C15H22O5
Molecular Weight: 282.33 
CAS NO: 63968-64-9
H bond acceptors: 5
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 53.99 Å2
Index of Refraction: 1.533
Molar Refractivity: 70.31 cm3
Molar Volume: 226.4 cm
Surface Tension: 43.5 dyne/cm
Density: 1.24 g/cm3
Flash Point: 172 °C
Enthalpy of Vaporization: 63.93 kJ/mol
Boiling Point: 389.9 °C at 760 mmHg
Vapour Pressure: 2.76E-06 mmHg at 25°C
Melting point: 156-157 °C(lit.)
Alpha: 76 o (c=0.5,MeOH)
Appearance: Crystalline Solid
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides. May absorb, and react with, carbon dioxide from the air. 
Product Categories of Artemisinin (CAS NO.63968-64-9): Active Pharmaceutical Ingredients;Miscellaneous Natural Products;Others (Antibiotics for Research and Experimental Use);Antibiotics for Research and Experimental Use;Biochemistry;Standard extract;Natural Plant Extract;Intermediates & Fine Chemicals;Pharmaceuticals;Miscellaneous Compounds

Uses

 Artemisinin (CAS NO.63968-64-9) is derived from a herb used in Chinese traditional medicine, though it is usually chemically modified and combined with other medications.Combination therapies that include artemisinin are the preferred treatment for malaria and are both effective and well tolerated in patients. It is also being studied as a treatment for cancer.

Production

 Artemisinin (CAS NO.63968-64-9) is isolated from the plant Artemisia annua. It is only produced when the plant is subjected to certain conditions, most likely biotic or abiotic stress.
Here is biosynthesis of Artemisinin .

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intramuscular > 800mg/kg (800mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Traditional Chinese Medicine Vol. 2, Pg. 31, 1982.
mouse LD unreported > 2gm/kg (2000mg/kg)   Antimicrobial Agents and Chemotherapy. Vol. 37, Pg. 1108, 1993.
mouse LD50 intramuscular 2800mg/kg (2800mg/kg)   Chinese Medical Journal Vol. 92, Pg. 811, 1979.
mouse LD50 intraperitoneal 1558mg/kg (1558mg/kg)   Chinese Medical Journal Vol. 92, Pg. 811, 1979.
mouse LD50 oral 4228mg/kg (4228mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Journal of Traditional Chinese Medicine Vol. 2, Pg. 31, 1982.
rat LD50 intramuscular 2571mg/kg (2571mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Journal of Traditional Chinese Medicine Vol. 2, Pg. 31, 1982.
rat LD50 oral 5576mg/kg (5576mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Journal of Traditional Chinese Medicine Vol. 2, Pg. 31, 1982.

Safety Profile

Safety Information about Artemisinin (CAS NO.63968-64-9):
Safety Statements: 22-24/25
22: Do not breathe dust
24/25: Avoid contact with skin and eyes 
WGK Germany: 2
Moderately toxic by ingestion, intramuscular, and intraperitoneal routes. When heated to decomposition it emits acrid smoke and fumes.

Specification

 Artemisinin (CAS NO.63968-64-9) is also called (+)-Arteannuin ; Qinghaosu  and [3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-one  .

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