Products Categories
CAS No.: | 64544-07-6 |
---|---|
Name: | Cefuroxime 1-acetoxyethyl ester |
Article Data: | 7 |
Molecular Structure: | |
Formula: | C20H22N4O10S |
Molecular Weight: | 510.481 |
Synonyms: | 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-furanyl(methoxyimino)acetyl]amino]-8-oxo-,1-(acetyloxy)ethyl ester, (6R,7R)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[[(aminocarbonyl)oxy]methyl]-7-[[2-furanyl(methoxyimino)acetyl]amino]-8-oxo-,1-(acetyloxy)ethyl ester, [6R-[6a,7b(Z)]]-;Altacef;Bioracef;CCI15641;Cefaks;Cefazine;Ceftin;Cefurax;Cefuroxime axetil;Elobact;Forcef;Oraxim;Zinat;Zinnat; |
EINECS: | 259-560-1 |
Density: | 1.61 g/cm3 |
Melting Point: | 175-180 °C |
Boiling Point: | 250°C (rough estimate) |
Appearance: | white to pale yellow powder |
Risk Codes: | R36/37/38 |
PSA: | 214.36000 |
LogP: | 0.86080 |
Conditions | Yield |
---|---|
With N,N-dimethyl-formamide; copper dichloride In ethyl acetate at 8 - 30℃; for 1.5h; Temperature; Concentration; | 98.2% |
trans-cefuroxime axetil
cefuroxime axetil
Conditions | Yield |
---|---|
In methanol; water at 25℃; Kinetics; Quantum yield; Irradiation; |
1-bromoethyl acetate
Cefuroxime
A
di-isopropyl ether
B
cefuroxime axetil
Conditions | Yield |
---|---|
With hydrogenchloride; potassium carbonate In ethyl acetate; N,N-dimethyl-formamide |
cefuroxime axetil
trans-cefuroxime axetil
Conditions | Yield |
---|---|
In methanol; water at 25℃; Kinetics; Quantum yield; Irradiation; | |
In propylene glycol for 4h; Solvent; UV-irradiation; | 4.7 g |
cefuroxime axetil
Conditions | Yield |
---|---|
In phosphate buffer at 37℃; for 24h; pH=7.4; Product distribution; Kinetics; Further Variations:; Solvents; |
cefuroxime axetil
Conditions | Yield |
---|---|
With morpholine In dichloromethane at 20℃; for 7h; Solvent; Reagent/catalyst; | 5.9 g |
What can I do for you?
Get Best Price
Altacef (Glenmark)
Biofuroksym (Bioton S.A.) Poland.Cefteja (Quadra)
Kilmax (Eskayef Bangladesh Limited), Bangladesh
Maxil (Hikma Pharmaceutica), Portugal
Ceftum (GlaxoSmithKline), India
Axet (500mg tablet) (Xeno Pharmaceuticals), Philippines
Forcef (Aristo), India
Cetil (Lupin)
Haginat (DHG PHARMA, Vietnam)
Ecocef (750mg IV) (Xeno Pharmaceuticals), Philippines
.
The Cefuroxime Axetil with CAS registry number of 64544-07-6 is also known as Cefuroxime 1-acetoxyethyl ester. The IUPAC name is 1-Acetyloxyethyl(6R,7R)-3-(carbamoyloxymethyl)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. Its EINECS registry number is 259-560-1. In addition, the formula is C20H22N4O10S and the molecular weight is 510.47. This chemical is a white to pale yellow powder and should be stored in sealed containers in cool, dry place and away from oxidizing agents.
Physical properties about Cefuroxime Axetil are: (1)ACD/LogP: 1.22; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): 1.22; (4)ACD/LogD (pH 7.4): 1.17; (5)ACD/BCF (pH 5.5): 4.96; (6)ACD/BCF (pH 7.4): 4.42; (7)ACD/KOC (pH 5.5): 109.43; (8)ACD/KOC (pH 7.4): 97.52; (9)#H bond acceptors: 14; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 12; (12)Polar Surface Area: 182.79Å2; (13)Index of Refraction: 1.665; (14)Molar Refractivity: 117.51 cm3; (15)Molar Volume: 316.3 cm3; (16)Surface Tension: 63.8 dyne/cm; (17)Density: 1.61 g/cm3.
Preparation of Cefuroxime Axetil: it is prepared by reaction of cefuroxime. Sodium of cefuroxime reacts with 1-ethyl bromoacetate to generate the product.
Uses of Cefuroxime Axetil: it has antibacterial activity for a variety of gram-positive bacteria, gram-negative bacteria and anaerobic bacteria. It's also mainly used in clinical respiratory infections, urinary tract infections, gonococcal infections, skin and soft tissue infections caused by susceptible strains.
You can still convert the following datas into molecular structure:
1. Canonical SMILES: CC(OC(=O)C)OC(=O)C1=C(CSC2N1C(=O)C2NC(=O)C(=NOC)C3=CC=CO3)COC(=O)N
2. Isomeric SMILES: CC(OC(=O)C)OC(=O)C1=C(CS[C@H]2N1C(=O)[C@H]2NC(=O)/C(=N\OC)/C3=CC=CO3)COC(=O)N
3. InChI: InChI=1S/C20H22N4O10S/c1-9(25)33-10(2)34-19(28)15-11(7-32-20(21)29)8-35-18-14(17(27)24(15)18)22-16(26)13(23-30-3)12-5-4-6-31-12/h4-6,10,14,18H,7-8H2,1-3H3,(H2,21,29)(H,22,26)/b23-13-/t10?,14-,18-/m1/s1
4. InChIKey: KEJCWVGMRLCZQQ-YJBYXUATSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | > 5gm/kg (5000mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: NAUSEA OR VOMITING | Chemotherapy Vol. 34(Suppl, |
mouse | LD50 | intraperitoneal | 510mg/kg (510mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Chemotherapy Vol. 34(Suppl, |
mouse | LD50 | oral | > 10gm/kg (10000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Chemotherapy Vol. 34(Suppl, |
mouse | LD50 | subcutaneous | 1840mg/kg (1840mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Chemotherapy Vol. 34(Suppl, |
rabbit | LD50 | oral | 200mg/kg (200mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Chemotherapy Vol. 34(Suppl, |
rat | LD50 | intraperitoneal | 950mg/kg (950mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Chemotherapy Vol. 34(Suppl, |
rat | LD50 | oral | > 10gm/kg (10000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Chemotherapy Vol. 34(Suppl, |
rat | LD50 | subcutaneous | 2500mg/kg (2500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Chemotherapy Vol. 34(Suppl, |