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| CAS No.: | 6457-49-4 |
|---|---|
| Name: | 4-Piperidinemethanol |
| Article Data: | 45 |
| Cas Database | |
| Molecular Structure: | |
|
|
|
| Formula: | C6H13NO |
| Molecular Weight: | 115.175 |
| Synonyms: | (4-Piperidinyl)methanol;(4-Piperidyl)methanol;4-(Hydroxymethyl)piperidine;4-Piperidine-1-methanol; |
| EINECS: | -0 |
| Density: | 0.951 g/cm3 |
| Melting Point: | 55-59 °C(lit.) |
| Boiling Point: | 198.2 °C at 760 mmHg |
| Flash Point: | 92.3 °C |
| Solubility: | Soluble in water |
| Appearance: | white to off-white crystalline powder, chunks |
| Hazard Symbols: |
 C,  Xi
|
| Risk Codes: | 34-22 |
| Safety: | 26-27-36/37/39-45 |
| Transport Information: | UN 3263 8/PG 2 |
| PSA: | 32.26000 |
| LogP: | 0.30710 |
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| Conditions | Yield |
|---|---|
| Stage #1: 4-carbethoxypiperidine With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; Stage #2: With sodium hydroxide; water In tetrahydrofuran at 20℃; for 0.5h; | 100% |
| Stage #1: 4-carbethoxypiperidine With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; Stage #2: With ethanol; water In tetrahydrofuran at 0℃; | 100% |
| With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; | 92% |
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 20h; Inert atmosphere; | 90% |
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In tetrahydrofuran at 21℃; for 24h; | 80% |
| Multi-step reaction with 2 steps 1: ethanolic HCl 2: ethanol; sodium View Scheme | |
| With sodium hydroxide; LiAlH4 In tetrahydrofuran; water |
- 383865-57-4
4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine
A
- 6457-49-4
4-piperidinemethanol
| Conditions | Yield |
|---|---|
| A n/a B 31% |
- 622387-50-2
4-(4-hydroxy-piperidine-1-sulfonyl)-tetrahydro-pyran-4-carboxylic acid tert-butyl ester
- 4282-40-0
1-Iodoheptane
- 6457-49-4
4-piperidinemethanol
| Conditions | Yield |
|---|---|
| Stage #1: 4-(4-hydroxy-piperidine-1-sulfonyl)-tetrahydro-pyran-4-carboxylic acid tert-butyl ester With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Stage #2: 1-Iodoheptane In tetrahydrofuran at 50℃; for 26h; | 20% |
- 399580-55-3
4-(methoxymethyl)piperidine
- 6457-49-4
4-piperidinemethanol
| Conditions | Yield |
|---|---|
| With water; hydrogen bromide |
| Conditions | Yield |
|---|---|
| With sulfuric acid; water; platinum at 65℃; Hydrogenation; | |
| With hydrogenchloride; PtO2 In ethanol; water |
| Conditions | Yield |
|---|---|
| With sodium; butan-1-ol |
- 1570-45-2
isonicotinic acid ethylester
- 71-36-3
butan-1-ol
A
- 6457-49-4
4-piperidinemethanol
B
- 1126-09-6
4-carbethoxypiperidine
- 101990-69-6
(2,6-dichloropyridin-4-yl)methanol
- 6457-49-4
4-piperidinemethanol
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: methanol. KOH-solution; palladium/barium carbonate / Hydrogenation 2: sulfuric acid; water; platinum / 65 °C / Hydrogenation View Scheme |
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Chemistry
Molecular Structure of 4-Piperidinemethanol (CAS NO.6457-49-4):
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IUPAC Name: Piperidin-4-ylmethanol
Canonical SMILES: C1CNCCC1CO
InChI: InChI=1S/C6H13NO/c8-5-6-1-3-7-4-2-6/h6-8H,1-5H2
InChIKey: XBXHCBLBYQEYTI-UHFFFAOYSA-N
Molecular Weight: 115.17352 [g/mol]
Molecular Formula: C6H13NO
XLogP3-AA: -0.1
H-Bond Donor: 2
H-Bond Acceptor: 2
Appearance: white to off-white crystalline powder, chunks
Melting Point: 55-59 °C(lit.)
Index of Refraction: 1.451
Molar Refractivity: 32.63 cm3
Molar Volume: 121 cm3
Surface Tension: 34.8 dyne/cm
Density: 0.951 g/cm3
Flash Point: 92.3 °C
Enthalpy of Vaporization: 50.54 kJ/mol
Boiling Point: 198.2 °C at 760 mmHg
Vapour Pressure: 0.0924 mmHg at 25°C
Sensitive: Hygroscopic
Product Categories: Alcohols and Derivatives; Amines and Anilines; pharmacetical; PiperidineDerivative; Hydroxymethyl's; Pyrans, Piperidines &Piperazines; Piperidine; Alkohols; Pyrans, Piperidines & Piperazines
Uses
4-Piperidinemethanol can be used in organic synthesis.
Safety Profile
Safety Information of 4-Piperidinemethanol (CAS NO.6457-49-4):
Hazard Codes: 
C,
Xi
Risk Statements: 34-22
R34:Causes burns.
R22:Harmful if swallowed.
Safety Statements: 26-27-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27:Take off immediately all contaminated clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3263 8/PG 2
WGK Germany: 3
Hazard Note: Irritant/Hygroscopic
HazardClass: 8
PackingGroup: III
Specification
4-Piperidinemethanol (CAS NO.6457-49-4), its Synonyms are 4-Piperidylmethanol ; 4-(Hydroxymethyl)piperidine ; 4-Piperidine-1-methanol .