CAS No.6469-93-8,Chlorprothixene hydrochloride Suppliers

Products Categories

Pharmaceutical (45)
Organic Chemicals (18)
Others (3)
Reagent (2)
Materials (1)

Basic Information

Molecular Structure:
CAS No.:	6469-93-8
Name:	Chlorprothixene hydrochloride

Formula:	C_18H₁₈ClNS . ClH
Molecular Weight:	352.3212
Synonyms:	1-Propanamine,3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-, hydrochloride, (3Z)-(9CI);1-Propanamine, 3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-,hydrochloride, (Z)-;Thioxanthene-D9,g-propylamine,2-chloro-N,N-dimethyl-, hydrochloride, (Z)- (8CI);9H-Thioxanthene,1-propanamine deriv.;Chlorprothixene hydrochloride;Truxal hydrochloride;cis-Chlorprothixene hydrochloride;
EINECS:	229-289-3
Melting Point:	221ºC
Boiling Point:	461.8 °C at 760 mmHg
Flash Point:	233.1 °C
Solubility:	Freely soluble in water
Appearance:	White powder
Hazard Symbols:	Xn
Risk Codes:	20/21/22
Safety:	36
Transport Information:	UN 2811 6
PSA:	28.54000
LogP:	5.99000

Total:58 Page 1 of 2 1 2 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 6469-93-8

Specification

Chlorprothixene hydrochloride , with cas registry number of 6469-93-8, has many other names such as 3-(2-Chlorothioxanthen-9-ylidene)-N,N-dimethyl-propan-1-amine hydrochloride . Its IUPAC name is (3Z)-3-(2-chlorothioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine hydrochloride . Besides these names, its own systematic name is called 3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine hydrochloride . The descriptors about its structure include SMILES: Cl.CN(C)CCC=C1c3ccccc3Sc2ccc(Cl)cc12, and InChI: InChI=1/C18H18ClNS.ClH/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18;/h3-4,6-10,12H,5,11H2,1-2H3;1H.

Some of physical properties include: H bond acceptors: 1, H bond donors: 0, Freely Rotating Bonds: 3, Enthalpy of Vaporization: 73.65 kJ/mol, Vapour Pressure: 6.29E-09 mmHg at 25°C. It is harmful by inhalation, in contact with skin and if swallowed. When use it, remember wear suitable protective clothing. And it should be stored at temp. of 2-8°C.

Chlorprothixene hydrochloride has been used as drug which is a kind of Antipsychotics. So a lot of toxicity data has been done such as:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	98mg/kg (98mg/kg)		Cesko-Slovenska Farmacie. Vol. 15, Pg. 526, 1966.
mouse	LD50	intravenous	43mg/kg (43mg/kg)	AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC BEHAVIORAL: EXCITEMENT BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 144, Pg. 481, 1963.
mouse	LD50	oral	242mg/kg (242mg/kg)	BEHAVIORAL: ATAXIA	Collection of Czechoslovak Chemical Communications. Vol. 45, Pg. 3166, 1980.
mouse	LD50	subcutaneous	140mg/kg (140mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 65, 1972.
rat	LD50	intravenous	25mg/kg (25mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 65, 1972.
rat	LD50	oral	200mg/kg (200mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 65, 1972.

As a drug, the purity is very important. There has been developed a liquid chromatographic method to control the related substances. The selective is both for (Z) chlorprothixene hydrochloride and its E-isomer with a limit of detection of 0.3 microgram ml^-1.